Recommended Readings: Erika Pearce, Ph.D., Wednesday September 20th, 2017

Special Seminar Series

Wednesday, September 20, 2017  4:00 p.m.

Carson Family Auditorium

Erika Pearce, Ph.D.

Senior Group Leader and Director

Department of Immunometabolism

Max Planck Institute of Immunobiology and Epigenetics

Mitochondrial Shapeshifting in the T Cell Response

Recommended Readings:

Erika Pearce. (2017). The Influence of Metabolism on the Function of T Cell Types. Latest Thinking.

Pan, Youdong; Tian, Tian; Park, Chang Ook; et al. (2017). Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. NATURE. 543 (7644): 252-+  

Man, Kevin; Kutyavin, Vassily I.; Chawla, Ajay. (2017). Tissue immunometabolism: development, physiology, and pathobiology. CELL METABOLISM. 25 (1): 11-26

Buck, Michael D.; O’Sullivan, David; Geltink, Ramon I. Klein; et al. (2016). Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL. 66 (1): 63-76

Liesa, Marc; Shirihai, Orian S. (2016). Mitochondrial Networking in T Cell Memory. CELL. 166 (1): 9-10

Peng, Min; Yin, Na; Chhangawala, Sagar; et al. (2016). Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. SCIENCE. 354 (6311): 481-484

Newton, Ryan; Priyadharshini, Bhavana; Turka, Laurence A. (2016). Immunometabolism of regulatory T cells. NATURE IMMUNOLOGY. 17 (6): 618-625

Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; et al. (2015). Mitochondrial function provides instructive signals for activation-induced B-cell fates. NATURE COMMUNICATIONS. 6: 6750

Pearce, Erika L.; Pearce, Edward J. (2013). Metabolic Pathways in Immune Cell Activation and Quiescence. IMMUNITY. 38 (4): 633-643 


Recommended Readings: Gulcin Pekkurnaz, Ph.D., September 21

Special Lecture
Monday, September 21, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gulcin Pekkurnaz, Ph.D.,
Postdoctoral Fellow,
Department of Neurobiology,
Harvard Medical School
Boston Children’s Hospital

Metabolic Regulation of Mitochondrial Function in the Nervous System

Recommended Readings

Empirical Articles

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D., & Schwarz, T. L. (2014). Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell, 158(1), 54-68. doi: 10.1016/j.cell.2014.06.007

Teodoro, R. O., Pekkurnaz, G., Nasser, A., Higashi‐Kovtun, M. E., Balakireva, M., McLachlan, I. G., … & Schwarz, T. L. (2013). Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst. The EMBO Journal, 32(14), 2039-2055. doi: 10.1038/emboj.2013.147

Review Papers

Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology, 5(6), a011304. doi: 10.1101/cshperspect.a011304

Recommended Readings: John Mekalanos, Ph.D. October 10

Friday Lecture Series
Friday, October 10, 2014
3:45 p.m., Caspary Auditorium

John Mekalanos, Ph.D.
Adele H. Lehman Professor of Microbiology
Chair, Department of Microbiology and Immunobiology,
Harvard Medical School

The Ghost in the Machine: Understanding Bacterial Secretion Systems Through Defining Their Effectors

Recommended Readings

Empirical Articles

Basler, M., Ho, B. T., & Mekalanos, J. J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell, 152(4), 884–894. doi:10.1016/j.cell.2013.01.042

Basler, M., Pilhofer, M., Henderson, G. P., Jensen, G. J., & Mekalanos, J. J. (2012). Type VI secretion requires a dynamic contractile phage tail-like structure. Nature, 483(7388), 182–186. doi:10.1038/nature10846

Ma, A. T., McAuley, S., Pukatzki, S., & Mekalanos, J. J. (2009). Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host & Microbe, 5(3), 234–243. doi:10.1016/j.chom.2009.02.005

Ma, A. T., & Mekalanos, J. J. (2010). In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation. Proceedings of the National Academy of Sciences, 107(9), 4365–4370. doi:10.1073/pnas.0915156107

Review Papers

Ho, B. T., Dong, T. G., & Mekalanos, J. J. (2014). A view to a kill: the bacterial type VI secretion system. Cell Host & Microbe, 15(1), 9–21. doi:10.1016/j.chom.2013.11.008