Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D., March 6

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, March 6, 2015
3:45 p.m., Caspary Auditorium

Jean-Laurent Casanova, M.D., Ph.D.,
Senior Attending Physician, Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Infectious Diseases of Childhood: Inborn Errors of Immunity?

Recommended Readings

Empirical Articles

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., … Casanova, J.-L. (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314(5797), 308–312. doi:10.1126/science.1128346

Taramasso, L., Boisson-Dupuis, S., Garre, M. L., Bondi, E., Cama, a, Nozza, P., … Marazzi, M. G. (2014). Pineal germinoma in a child with interferon-gamma receptor 1 deficiency. case report and literature review. Journal of Clinical Immunology, 34(8), 922–927. doi:10.1007/s10875-014-0098-0

Von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., … Casanova, J.-L. (2008). Pyogenic bacterial infections in humans with MyD88 deficiency. Science, 321(5889), 691–696. doi:10.1126/science.1158298

Review Papers

Casanova, J.-L., & Abel, L. (2002). Genetic dissection of immunity to mycobacteria: the human model. Annual Review of Immunology, 20, 581–620. doi:10.1146/annurev.immunol.20.081501.125851

Casanova, J.-L., & Abel, L. (2013). The genetic theory of infectious diseases: a brief history and selected illustrations. Annual Review of Genomics and Human Genetics, 14, 215–243. doi:10.1146/annurev-genom-091212-153448

Conley, M. E., & Casanova, J. L. (2014). Discovery of single-gene inborn errors of immunity by next generation sequencing. Current Opinion in Immunology, 30, 17–23. doi:10.1016/j.coi.2014.05.004

Recommended Readings: Zhijian ‘James’ Chen, Ph.D. September 26

Friday Lecture Series
Friday, September 26, 2014
3:45 p.m., Caspary Auditorium

Zhijian “James” Chen, Ph.D.
George L. MacGregor Distinguished Chair in Biomedical Sciences,
Director, Center for Inflammation,
Research Professor, Department of Molecular Biology,

The University of Texas Southwestern Medical Center
Investigator, Howard Hughes Medical Institute

Enemy Within – Immune and Autoimmune Responses to cytosolic DNA and RNA

Recommended Readings

Empirical Articles

Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., … Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science, 341(6148), 903–906. doi:10.1126/science.1240933

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science, 341(6152), 1390–1394. doi:10.1126/science.1244040

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science, 339(6121), 786–791. doi:10.1126/science.1232458

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., … Chen, Z. J. (2010). Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell, 141(2), 315–330. doi:10.1016/j.cell.2010.03.029

Review Papers

Cai, X., Chiu, Y.-H., & Chen, Z. J. (2014). The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Molecular Cell, 54(2), 289–296. doi:10.1016/j.molcel.2014.03.040

Wu, J., & Chen, Z. J. (2014). Innate immune sensing and signaling of cytosolic nucleic acids. Annual Review of Immunology, 32, 461–88. doi:10.1146/annurev-immunol-032713-120156