Recommended Readings: Erika Pearce, Ph.D., Wednesday September 20th, 2017

Special Seminar Series

Wednesday, September 20, 2017  4:00 p.m.

Carson Family Auditorium

Erika Pearce, Ph.D.

Senior Group Leader and Director

Department of Immunometabolism

Max Planck Institute of Immunobiology and Epigenetics

Mitochondrial Shapeshifting in the T Cell Response

Recommended Readings:

Erika Pearce. (2017). The Influence of Metabolism on the Function of T Cell Types. Latest Thinking.

Pan, Youdong; Tian, Tian; Park, Chang Ook; et al. (2017). Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. NATURE. 543 (7644): 252-+  

Man, Kevin; Kutyavin, Vassily I.; Chawla, Ajay. (2017). Tissue immunometabolism: development, physiology, and pathobiology. CELL METABOLISM. 25 (1): 11-26

Buck, Michael D.; O’Sullivan, David; Geltink, Ramon I. Klein; et al. (2016). Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL. 66 (1): 63-76

Liesa, Marc; Shirihai, Orian S. (2016). Mitochondrial Networking in T Cell Memory. CELL. 166 (1): 9-10

Peng, Min; Yin, Na; Chhangawala, Sagar; et al. (2016). Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. SCIENCE. 354 (6311): 481-484

Newton, Ryan; Priyadharshini, Bhavana; Turka, Laurence A. (2016). Immunometabolism of regulatory T cells. NATURE IMMUNOLOGY. 17 (6): 618-625

Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; et al. (2015). Mitochondrial function provides instructive signals for activation-induced B-cell fates. NATURE COMMUNICATIONS. 6: 6750

Pearce, Erika L.; Pearce, Edward J. (2013). Metabolic Pathways in Immune Cell Activation and Quiescence. IMMUNITY. 38 (4): 633-643 


Recommended Readings: Kivanc Birsoy, Ph.D., January 14

Special Lecture
Friday, January 14, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Kivanc Birsoy, Ph.D.
Jane Coffin Childs Medical Fund Fellow,
Whitehead Institute for Biomedical Research
Broad Institute of Harvard and MIT

Systematic Approaches to Study Metabolic Plasticity of Cancer Cells

Recommended Readings

Empirical Articles

Birsoy, K., Possemato, R., Lorbeer, F. K., Bayraktar, E. C., Thiru, P., Yucel, B., … Sabatini, D. M. (2014). Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature, 508(7494), 108–112. doi:10.1038/nature13110

Birsoy, K., Wang, T., Possemato, R., Yilmaz, O. H., Koch, C. E., Chen, W. W., … Sabatini, D. M. (2013). MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics, 45(1), 104–108. doi:10.1038/ng.2471

Grabiner, B. C., Nardi, V., Birsoy, K., Possemato, R., Shen, K., Sinha, S., … Sabatini, D. M. (2014). A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery, 4(5), 554–563. doi:10.1158/2159-8290.CD-13-0929

Review Papers

Birsoy, K., Sabatini, D. M., & Possemato, R. (2012). Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine, 18(7), 1022–1023. doi:10.1038/nm.2870