Recommended Readings: Stephen C. Harrison, Ph.D. November 21

Friday Lecture Series
Friday, November 21, 2014,
3:45 p.m., Caspary Auditorium

Stephen C. Harrison, Ph.D.
Giovanni Armenise-Harvard Professor of Basic Medical Sciences,
Professor of Biological Chemistry and Molecular Pharmacology,
Professor of Pediatrics,
Director of the Center for Molecular and Cellular Dynamics,
Harvard Medical School
Head of the Laboratory of Molecular Medicine,
Children’s Hospital, Boston
Investigator,
Howard Hughes Medical Institute

Molecular Mechanisms of Membrane Penetration When Viruses Enter Cells

Recommended Readings

Empirical Articles

Abdelhakim, A. H., Salgado, E. N., Fu, X., Pasham, M., Nicastro, D., Kirchhausen, T., & Harrison, S. C. (2014). Structural correlates of rotavirus cell entry. PLoS Pathogens, 10(9), e1004355. doi:10.1371/journal.ppat.1004355

Ivanovic, T., Choi, J. L., Whelan, S. P., van Oijen, A. M., & Harrison, S. C. (2013). Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife, 2(1), e00333. doi:10.7554/eLife.00333

Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T., Khurana, S., King, L. R., … Harrison, S. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264–269. doi:10.1073/pnas.1218256109

Review Article

Harrison, S. C. (2008). Viral membrane fusion. Nature Structural & Molecular Biology, 15(7), 690–698. doi:10.1038/nsmb.1456

Recommended Readings: James Rothman, Ph.D. November 7

Friday Lecture Series
Friday, November 7, 2014
3:45 p.m., Caspary Auditorium

James Rothman, Ph.D.
Fergus F. Wallace Professor Biomedical Sciences and Chemistry,
Professor and Chair,
Department of Cell Biology,
Professor of Chemistry,
Yale School of Medicine

The Regulation of Neurotransmitter Release

Recommended Readings

Empirical Articles

McNew, J. A., Parlati, F., Fukuda, R., Johnston, R. J., Paz, K., Paumet, F., … Rothman, J. E. (2000). Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature, 407(6801), 153–159. doi:10.1038/35025000

Söllner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., & Rothman, J. E. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature, 362(6418), 318–324. doi:10.1038/362318a0

Weber, T., Zemelman, B. V, McNew, J. a, Westermann, B., Gmachl, M., Parlati, F., … Rothman, J. E. (1998). SNAREpins: Minimal Machinery for Membrane Fusion. Cell, 92(6), 759–772. doi:10.1016/S0092-8674(00)81404-X

Wilson, D. W., Wilcox, C. A., Flynn, G. C., Chen, E., Kuang, W. J., Henzel, W. J., … Rothman, J. E. (1989). A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature, 339(6223), 355–359. doi:10.1038/339355a0

Review Papers

Rothman, J. E. (2014). The principle of membrane fusion in the cell (Nobel lecture). Angewandte Chemie, 2–21. doi:10.1002/anie.201402380

Südhof, T. C., & Rothman, J. E. (2009). Membrane fusion: grappling with SNARE and SM proteins. Science, 323(5913), 474–477. doi:10.1126/science.1161748