Recommended Readings: Gregory Alushin, Ph.D., February 24

Special Lecture Series
Wednesday, February 24, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Gregory Alushin, Ph.D.
Early Independent Scientist,
National Heart Lung and Blood Institute

Cytoskeletal Structural Plasticity in Force Generation and Mechanosensation

Recommended Reading

Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014). High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis. Cell, 157(5), 1117-1129. doi: 10.1016/j.cell.2014.03.053.

Kim, L. Y., Thompson, P. M., Lee, H. T., Pershad, M., Campbell, S. L., & Alushin, G. M. (2015). The structural basis of actin organization by vinculin and metavinculin. Journal of Molecular Biology. doi: 10.1016/j.jmb.2015.09.031.

Zhang, R., Alushin, G. M., Brown, A., & Nogales, E. (2015). Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins. Cell, 162(4), 849-859. doi: 10.1016/j.cell.2015.07.012.

Recommended Readings: Natasha Mhatre, Ph.D., May 13, 2015

Special Seminar
Wednesday, May 13, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Natasha Mhatre, Ph.D.
Postdoctoral Research Fellow,
University of Toronto at Scarborough

The Sensory Ecology and Evolutionary Origins of Actively Amplified Mechanotransduction:
From Insects to Algae

Recommended Readings

Empirical Articles

Mhatre, N., Montealegre-Z, F., Balakrishnan, R., & Robert, D. (2012). Changing resonator geometry to boost sound power decouples size and song frequency in a small insect. Proceedings of the National Academy of Sciences, 109(22), E1444–E1452. doi:10.1073/pnas.1200192109

Mhatre, N., & Robert, D. (2013). A tympanal insect ear exploits a critical oscillator for active amplification and tuning. Current Biology, 23(19), 1952–1957. doi:10.1016/j.cub.2013.08.028

Rajaraman, K., Mhatre, N., Jain, M., Postles, M., Balakrishnan, R., & Robert, D. (2013). Low pass filters and differential tympanal tuning in a paleotropical bushcricket with an unusually low frequency call. Journal of Experimental Biology, 216(5), 777–787. doi:10.1242/jeb.078352

Review Paper

Mhatre, N. (2015). Active amplification in insect ears: mechanics, models and molecules. Journal of Comparative Physiology A, 201(1), 19–37. doi:10.1007/s00359-014-0969-0

Recommended Readings: Sheetz, M., Kenan, W., Spudich, J., and Vale, R.

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Biological Motility and Mechanotransduction

Michael Sheetz, Ph.D., William R. Kenan Jr. Professor,Columbia University, 

Myosin Pulling and Mechanotransduction

James Spudich, Ph.D., professor of biochemistry, Stanford School of Medicine, Hypertrophic and Dilated Cardiomyopathies:

Single Molecule Analysis of Human Cardiac Myosin

Ronald Vale, Ph.D., professor, University of California, San Francisco; investigator, Howard Hughes Medical Institute (HHMI),

Structure and Mechanism of the Dynein Motor Protein

April 6, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Carter, A. P., C. Cho, L. Jin, and R. D. Vale. 2011. “Crystal Structure of the Dynein Motor Domain.” Science 331 (6021): 1159-1165

Chuan, P., J. A. Spudich, and A. R. Dunn. 2011. “Robust Mechanosensing and Tension Generation by Myosin VI.” Journal of Molecular Biology 405 (1): 105-112

Hartman, M. A., D. Finan, S. Sivaramakrishnan, and J. A. Spudich. 2011. Principles of Unconventional Myosin Function and Targeting. Annual Review of Cell and Developmental Biology. Vol. 27: 133-155

Kardon, J. R. and R. D. Vale. 2009. “Regulators of the Cytoplasmic Dynein Motor.” Nature Reviews Molecular Cell Biology 10 (12): 854-865

Vogel, V. and M. Sheetz. 2006. “Local Force and Geometry Sensing Regulate Cell Functions.” Nature Reviews Molecular Cell Biology 7 (4): 265-275

Vogel, V. and M. P. Sheetz. 2009. “Cell Fate Regulation by Coupling Mechanical Cycles to Biochemical Signaling Pathways.” Current Opinion in Cell Biology 21 (1): 38-46