Recommended Readings: Yasunori Saheki, M.D., Ph.D., February 4

Special Lecture Series
Wednesday, February 4, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Yasunori Saheki, M.D., Ph.D.
Postdoctoral Fellow,
Department of Cell biology,
Yale University School of Medicine;
Howard Hughes Medical Institute

Crosstalk between the Endoplasmic Reticulum and the Plasma Membrane Mediated by the Extended SynaptotagminsRecommended Readings

Recommended Readings

Giordano, F., Saheki, Y., Idevall-Hagren, O., Colombo, S. F., Pirruccello, M., Milosevic, I., … De Camilli, P. (2013). PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell, 153(7), 1494–1509. doi:10.1016/j.cell.2013.05.026

Schauder, C. M., Wu, X., Saheki, Y., Narayanaswamy, P., Torta, F., Wenk, M. R., … Reinisch, K. M. (2014). Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature, 510(7506), 552–555. doi:10.1038/nature13269

Recommended Readings: Kai Simmons, M.D.

Friday Lecture Series

Lipids Organizing Cell Membranes

Kai Simons, M.D., research group leader and director emeritus,

Max Planck Institute of Molecular Cell Biology and Genetics

February 17, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Coskun, U., and K. Simons. 2011. Cell membranes: The lipid perspective. Structure 19, (11): 1543-1548

Levental, I., M. Grzybek, and K. Simons. 2010. Greasing their way: Lipid modifications determine protein association with membrane rafts. Biochemistry 49, (30): 6305-6316

Lingwood, D., and K. Simons. 2010. Lipid rafts as a membrane-organizing principle. Science 327, (5961): 46-50

Shevchenko, A., and K. Simons. 2010. Lipidomics: Coming to grips with lipid diversity. Nature Reviews Molecular Cell Biology 11, (8): 593-598

Simons, K., and M. J. Gerl. 2010. Revitalizing membrane rafts: New tools and insights. Nature Reviews Molecular Cell Biology 11, (10): 688-699

Research Indicates Potential New Class of Vaccines

New research has revealed properties of a potential vaccine adjuvant that suggest it could be useful for enhancing protection against a number of different infections.  These studies  advance the hypothesis that lipid molecules may serve as promising vaccine components. The studies demonstrate that NKT cells can help B cells produce antibodies that recognize lipids, but this does not result in long-lived memory immune responses to the lipid antigens. Second, the studies demonstrate that the lipids, when used as adjuvants to enhance immune responses to more conventional protein antigens, induce memory immune responses against the protein target without inducing a memory response to the lipid itself. Together, these findings suggest a single lipid adjuvant could be used multiple times without losing its effect. The new research also characterizes how NKT cells help B cells produce antibodies when lipids are used as a vaccine adjuvant.

This new data is published in the January 2012 issue of the journal Nature Immunology.