Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight


Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578



Recommended Readings: Gerard Karsenty, M.D., Ph.D., January 16

Friday Lecture Series
Friday, January 16, 2015
3:45 p.m., Caspary Auditorium

Gerard Karsenty, M.D., Ph.D.
Paul A. Marks, M.D., Professor and Chairman
Department of Genetics & Development
Columbia University Medical Center

The Contribution of Bone to Whole Organism Physiology

Recommended Readings

Empirical Articles

Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., … Karsenty, G. (2000). Leptin inhibits bone formation through a hypothalamic relay : A central control of bone mass. Cell, 100(2), 197–207. doi:10.1016/S0092-8674(00)81558-5

Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., … Karsenty, G. (2007). Endocrine regulation of energy metabolism by the skeleton. Cell, 130(3), 456–469. doi:10.1016/j.cell.2007.05.047

Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., … Karsenty, G. (2002). Leptin regulates bone formation via the sympathetic nervous system. Cell, 111(3), 305–317. doi:10.1016/S0092-8674(02)01049-8

Review Papers

Karsenty, G., & Ferron, M. (2012). The contribution of bone to whole-organism physiology. Nature, 481(7381), 314–20. doi:10.1038/nature10763

Karsenty, G., & Oury, F. (2012). Biology without walls: the novel endocrinology of bone. Annual Review of Physiology, 74, 87–105. doi:10.1146/annurev-physiol-020911-153233

Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D. May 20, 2013

Monday Lecture Series
To Eat or Not To Eat: Studies of a Complex Motivational Behavior
Jeffrey M. Friedman, M.D. , Ph.D.
Marilyn M. Simpson Professor, Laboratory of Molecular Genetics
Investigator, Howard Hughes Medical Institute
Carson Family Auditorium, CRC
4:00 p.m., Refreshments 3:45

Recommended Readings:

L Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. 2011. Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE . 14(12):1562-U92 DOI: 10.1038/nn.2977

Scott, Michael M.; Lachey, Jennifer L.; Sternson, Scott M.; et al. 2009. Leptin Targets in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY. 514(5): 518-532 DOI: 10.1002/cne.22025

Adam, Tanja C.; Epel, Elissa S. 2007. Stress, eating and the reward system. Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior. Location: Naples, Florida, JUL 18-22, 2006. Society for the Study of Ingestive Behavior. PHYSIOLOGY & BEHAVIOR. 91(4, Sp. Issue SI): 449-458 DOI: 10.1016/j.physbeh.2007.04.011

Heisler, Lora K.; Jobst, Erin E.; Sutton, Gregory M.; et al 2006. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. NEURON. 51(2): 239-249 DOI: 10.1016/j.neuron.2006.06.004

Alon, T; Friedman, JM. 2006. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. JOURNAL OF NEUROSCIENCE . 26(2): 389-397 DOI: 10.1523/JNEUROSCI.1203-05.2006

Figlewicz, DP; Bennett, J; Evans, SB; et al. 2004. Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. BEHAVIORAL NEUROSCIENCE . 118(3): 479-487 DOI: 10.1037/0735-7044.118.3.479  REQUEST ARTICLE FROM MARKUS LIBRARY

Pinto, S; Roseberry, AG; Liu, HY; et al. 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. SCIENCE . 304(5667): 110-115 DOI: 10.1126/science.

Recommended Readings: Jeffrey M. Friedman M.D., Ph.D.

Monday Lectures

Leptin and the Homeostratic Control of

Food Intake and Body Weight

Jeffrey M. Friedman M.D., Ph.D.

Howard Hughes Medical Institute

The Rockefeller University

4 p.m.  (refreshments at 3:45)

Monday, December 8, 2008

Welch Hall Level Two

Recommended Review:

Morrison, Christopher D. and Hans-Rudolf Berthoud.  2007.  Neurobiology of nutrition and obesity. Nutrition Reviews.  65(12):517-534.

Related Articles:

Rodenheffer, Matthew S.; Birsoy, Kivanc; and Jeffrey M. Friedman.  2008.   Identification of white adipocyte progenitor cells in vivo.   Cell. 135(2):240-249.


Birsoy, Kivanc; Chen, Zhu; and Jeffrey M. Friedman.  2008.  Transcriptional regulation of adipogenesis by KLF4.  Cell Metabolism.  7(4):339-347.  


Berthoud, Hans-Rudolf.  2007.  Interactions between the “cognitive” and “metabolic” brain in the control of food intake. Physiology & Behavior.  91(5):486-498.


Ruano, G.; J.W.  Goethe, et al.  2007.  Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients.  Molecular Psychiatry.  12(5):474-482.


Berthoud, Hans-Rudolf.  2006. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance.  Obesity.  14(Suppl 5):197-200.    Request article from Markus Library.