Recommended Readings: Kevan Shokat, Ph.D.

Friday Lecture Series

The William H. Stein Memorial Lecture

A New Druggable Pocket on K-Ras and a Neo-substrate for Activating the Kinase

PINK in Parkinson’s Disease

Kevan Shokat, Ph.D., professor and chair, department of cellular and molecular

pharmacology, University of California, San Francisco;

investigator, Howard Hughes Medical Institute

November 22, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Hertz, N. T., Berthet, A., Sos, M. L., Thorn, K. S., Burlingame, A. L., Nakamura, K., & Shokat, K. M. (2013). A neo-substrate that amplifies catalytic activity of parkinson’s-disease- related kinase PINK1. Cell, 154(4), 737-747

Larochelle, S., Amat, R., Glover-Cutter, K., Sansó, M., Zhang, C., Allen, J. J., . . . Fisher, R. P. (2012). Cyclin-dependent kinase control of the initiation-to-elongation switch of polymerase II. Nature Structural and Molecular Biology, 19(11), 1108-1115

Soskis, M. J., Ho, H. -. H., Bloodgood, B. L., Robichaux, M. A., Malik, A. N., Ataman, B., . . . Greenberg, M. E. (2012). A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience, 15(12), 1645-1654

Statsuk, A. V., & Shokat, K. M. (2012). Covalent cross-linking of kinases with their corresponding peptide substrates. Methods in Molecular Biology 795 , pp. 179-190

Sun, Y., Miao, Y., Yamane, Y., Zhang, C., Shokat, K. M., Takematsu, H., . . . Drubin, D. G. (2012). Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the pkh-ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell, 23(12), 2388-2398

Ultanir, S., Hertz, N., Li, G., Ge, W. -., Burlingame, A., Pleasure, S., . . . Jan, Y. -. (2012). Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 uncovers their roles in dendrite arborization and spine development. Neuron, 73(6), 1127-1142

 

Related Readings: Dorothea Fiedler, Ph.D.

Lecture Series

A Genetic Map of the S. cerevisiae Phosphorylation Network

Dorothea Fiedler, Ph.D.

Post-Doctoral Fellow, Department of Cellular and Molecular Pharmacology

University of California, San Francisco

Monday, January 12, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Related Articles:

Tamgüney, T., C. Zhang, D. Fiedler, K. Shokat, and D. Stokoe. 2008. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Experimental Cell Research. 314(11-12):2299-2312.

Wang, J., Z. A. Knight, D. Fiedler, O. Williams, K. M. Shokat, and D. Pearce. 2008. Activity of the p110-α subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. American Journal of Physiology – Renal Physiology. 295(3):F843-F850.