Recommended Readings: Rod MacKinnon, M.D., Ph.D., April 11

Monday Lecture Series
Monday, April 11, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Rod MacKinnon, M.D., Ph.D.
John D. Rockefeller Jr. Professor and Head,
Laboratory of Molecular Neurobiology and Biophysics,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Some Experiments That Excite Me Right Now

Recommended Readings

Brohawn, S. G., Campbell, E. B., & MacKinnon, R. (2014). Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516(7529), 126-130. doi:10.1038/nature14013

Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., … & MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360), 69-77. doi:10.1126/science.280.5360.69

Hite, R. K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., & MacKinnon, R. (2015). Cryo-electron microscopy structure of the Slo2. 2 Na+-activated K+ channel. Nature, 527(7577), 198-203.  doi:10.1038/nature14958

MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angewandte Chemie, 43(33), 4265-4277.

Neuroscientists Learn How Channels Fine-Tune Neuronal Excitability

 Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The discovery, published in the journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level.

Recommended Readings: Lily Jan Ph.D. Friday Oct. 23, 2009

Friday Lecture Series

Recent Studies of Potassium Channels and Calcium-activated Chloride Channels

Lily Jan, Ph.D.,

Jack and Delores Change Endowed Chair in Physiology and Biophysics

University of California San Francisco, Investigator, HHMI

October 23, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Horresh I, Poliak S, Grant S, et al..  2008. Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons. JOURNAL OF NEUROSCIENCE 28(52): 14213-14222

Goldberg EM, Clark BD, Zagha E, et al..  2008. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. NEURON 58 (3): 387-400

Kole MHP, Letzkus JJ, Stuart GJ.  2007. Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. NEURON 55( 4): 633-647

Gu C, Zhou W, Puthenveedu MA, et al.  2006.  The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. NEURON 52(5 ): 803-816

Kleopa KA, Elman LB, Lang B, et al.  2006.  Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. BRAIN 129(Part 6):1570-1584

Hasband MN, Park EW, Zhen DK, et al.  2002.  Clustering of neuronal potassium channels is independent of their interaction with PSD-95. JOURNAL OF CELL BIOLOGY 159(4): 663-672

Poliak S, Gollan L, Martinez R, et al.  1999.  Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.  NEURON 24(4): 1037-1047

Klumpp DJ, Song EJ, Ito S, et al.  1995.  The Shaker-like potassium channels of the mouse rod  bipolar cell and their contributions to the membrane current. JOURNAL OF NEUROSCIENCE 15 (7): 5004-5013 Part 1

Sheng M, Tsaur ML, Jan YN, et al.  1994.  Contrasting subcellular localization of the KV1.2 K+ channel subunit in different neurons of rat brain. JOURNAL OF NEUROSCIENCE 14( 4): 2408-2417

Related Readings: A. James Hudspeth, M.D., Ph.D.

Friday Lecture Series

Making an Effort to Listen: Mechanical Amplification by Myosin Molecules and Ion Channels in Hair Cells of the Inner Ear

A. James Hudspeth, M.D., Ph.D.

Howard Hughes Medical Institute and The Rockefeller University
New York, New York, USA

3:15 pm – Refreshments, Abby Lounge

3:45 pm – 5:00 pm – Lecture

Friday, October 31, 2008

Caspary Auditorium

Recommended Articles:

Hudspeth, A.J. 2008. Making an Effort to Listen: Mechanical Amplification in the Ear. Neuron 59(4):530-545. 

Nagiel, A., Andor-Ardó, D., Hudspeth, A.J. 2008. Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish. The Journal of Neuroscience 28(34)8442-8453.
(Request a PDF from the Markus Library)

Kozlov, A.S., Risler, T., Hudspeth, A.J. 2007. Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels. Nature Neuroscience 10(1):87-92.

Hudspeth, A.J., Konishi, M. 2000. Auditory neuroscience: Development, transduction, and integration. Proceedings of the National Academy of Sciences of the United States of America 97(22):11690-11691.

Hudspeth, A.J. 1997. Mechanical amplification of stimuli by hair cells. Current Opinion in Neurobiology. 7(4):480-486.
Hudspeth, A.J. 1989. How the ear’s works work. Nature 341(6241):397-404.

Hudspeth, A.J. 1986. The ionic channels of a vertebrate hair cell. Hearing Research 22:21-27.