Recommended Readings: Lewis Cantley, Ph.D. Friday March 16, 2018

Friday Lectures

Friday, March 16, 2018  3:45 p.m.

Caspary Auditorium

Lewis Cantley, Ph.D.

Meyer Director of the Sandra and Edward Meyer Cancer Center


Professor of Cancer Biology in Medicine

Weill Cornell Medicine and New York-Presbyterian Hospital

PI 3-Kinase: Linking Obesity, Insulin Resistance, and Cancer

Recommended Readings:

Empirical Articles

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. (2018). Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. CANCER DISCOVERY. 8 (3):354-369

Waldhart, Althea N.; Dykstra, Holly; Peck, Anderson S.; et al. (2017).  Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. CELL REPORTS. 19 (10)2005-2013

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, et al. (2017). PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. CLINICAL CANCER RESEARCH. doi: 10.1158/1078-0432.CCR-17-2141

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4)605-635 

Thorpe, Lauren M.; Spangle, Jennifer M.; Ohlson, Carolynn E.; et al. (2017). PI3K-p110 alpha mediates the oncogenic activity induced by loss of the novel tumor suppressorPI3K-p85 alpha. PNAS.114 (27)7095-7100

Juvekar, Ashish; Hu, Hai; Yadegarynia, Sina; et al. (2016). Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. PNAS. 113 (30): E4338-E4347

Review Papers

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4): 605-635

Heiden, Matthew G. Vander; Cantley, Lewis C.; Thompson, Craig B. (2009). Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. SCIENCE. 324 (5930): 1029-1033

Yuan, T. L.; Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. ONCOGENE. 27 (41): 5497-5510

Book Chapter

Lien, Evan C.; Lyssiotis, Costas A.; Cantley, Lewis C. (2016). Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. METABOLISM IN CANCER. 207: 39-72

Yuan, Tina L.; Cantley, Lewis C. (2010). Phosphoinositide 3-kinase in Health and Disease Volume 1 Introduction. PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE, VOL1. Current Topics in Microbiology and Immunology. 346: 1-7


Recommended Readings: Ronald M. Evans, Ph.D., December 19

Friday Lecture Series
Friday, December 19, 2014
3:45 p.m, Caspary Auditorium

Ronald M. Evans, Ph.D.,
Professor and Director,
Gene Expression Laboratory,
March of Dimes Chair in Molecular and Developmental Biology,
Salk Institute for Biological Studies
Investigator, Howard Hughes Medical Institute

Nuclear Receptors and Diabesity: a Roadmap to Human Health

Recommended Readings

Empirical Articles

Jonker, J. W., Suh, J. M., Atkins, A. R., Ahmadian, M., Li, P., Whyte, J., … Evans, R. M. (2012). A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature, 485(7398), 391–394. doi:10.1038/nature10998

Suh, J. M., Jonker, J. W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., … Evans, R. M. (2014). Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature, 513(7518), 436–439. doi:10.1038/nature13540

Review Papers

Evans, R. M., & Mangelsdorf, D. J. (2014). Nuclear Receptors, RXR, and the Big Bang. Cell, 157(1), 255–66. doi:10.1016/j.cell.2014.03.012

Hong, S.-H., Ahmadian, M., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2014). Nuclear receptors and metabolism: from feast to famine. Diabetologia, 57(5), 860–867. doi:10.1007/s00125-014-3209-9

Recommended Readings: Juleen R. Zierath, Ph.D.

Friday Lecture Series

Nicholson Lecture

Molecular Mechanisms for the Health-promoting Effects of Exercise: Why Muscle Matters!

Juleen R. Zierath, Ph.D., professor of physiology, department of molecular

medicine and surgery, Section for Integrative Physiology, Karolinska Institutet;

professor of integrative physiology and scientific director,

Novo Nordisk Foundation Center for Basic Metabolic Research,

Copenhagen University

October 25, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., . . . Zierath, J. R. (2012). Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metabolism, 15(3), 405-411

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., . . . Auwerx, J. (2010). Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism, 11(3), 213-219

Egan, B., Carson, B. P., Garcia-Roves, P. M., Chibalin, A. V., Sarsfield, F. M., Barron, N., . . . O’Gorman, D. J. (2010). Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. Journal of Physiology, 588(10), 1779-1790

Egan, B., O’Connor, P. L., Zierath, J. R., & O’Gorman, D. J. (2013). Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS ONE, 8(9)

Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metabolism, 17(2), 162-184

Russell, A. P., Lamon, S., Boon, H., Wada, S., Güller, I., Brown, E. L., . . . Akimoto, T. (2013). Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. Journal of Physiology, 591(18), 4637-4653

Szekeres, F., Chadt, A., Tom, R. Z., Deshmukh, A. S., Chibalin, A. V., Björnholm, M., . . . Zierath, J. R. (2012). The rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. American Journal of Physiology – Endocrinology and Metabolism, 303(4), E524-E533


Insulin Nasal Spray May Slow Alzheimer’s Disease

Intranasal insulin therapy may have beneficial effects on cognition and function among patients with Alzheimer’s disease, a pilot study suggested.

Patients who received 20 IU of intranasal insulin daily for four months had improvements on delayed story recall tests (P=0.02, Cohen f effect size=0.36), according to Suzanne Craft, PhD, of the Veterans Affairs Puget Sound Health Care System in Seattle, and colleagues.

And compared with placebo, baseline scores on the Dementia Severity Rating Scale were maintained over the study period in patients receiving either 20 IU or 40 IU of the insulin (P=0.01 for both, Cohen f = 0.38 for 20 IU and 0.41 for 40 IU), the researchers reported online in the Archives of Neurology.