Recommended Readings: Jean-Laurent Casanova, Ph.D. December 1

Monday Lecture Series
Monday, December 1, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Jean-Laurent Casanova, Ph.D.,
Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator,
Howard Hughes Medical Institute

Toward a Genetic Theory of Childhood Infectious Diseases

Recommended Readings

Empirical Articles

Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., … Casanova, J.-L. (2011). Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science, 332(6025), 65–68. doi:10.1126/science.1200439

Sabri, A., Grant, A. V, Cosker, K., El Azbaoui, S., Abid, A., Abderrahmani Rhorfi, I., … El Baghdadi, J. (2014). Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. The Journal of Infectious Diseases, 210(4), 611–618. doi:10.1093/infdis/jiu140

Review Papers

Alcaïs, A., Quintana-Murci, L., Thaler, D. S., Schurr, E., Abel, L., & Casanova, J.-L. (2010). Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Annals of the New York Academy of Sciences, 1214, 18–33. doi:10.1111/j.1749-6632.2010.05834.x

Casanova, J.-L., & Abel, L. (2005). Inborn errors of immunity to infection: the rule rather than the exception. The Journal of Experimental Medicine, 202(2), 197–201. doi:10.1084/jem.20050854

How Pathogenic Bacteria Hide Inside Host Cells

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how the bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how ‘phenotype switching’ enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

NATURE Conferences: Genomics of Infectious Diseases in March

The American Society of Human Genetics (ASHG), The Human Genome Organisation (HUGO) and Nature Publishing Group are pleased to announce: Genetics and Genomics of Infectious Diseases March 21-24, 2009, The Ritz Carlton Millenia Hotel, Singapore

Early Bird Registration has been extended to January 30.

Classical and emerging infectious diseases, viral pandemics, and drug-resistant pathogens remain challenges to human health. However, contemporary advances in genetics and genomic technologies provide new approaches to understanding and combating these diseases. The American Society of Human Genetics (ASHG) and the Human Genome Organisation (HUGO) are partnering with Nature Publishing Group (NPG) to organize an international conference to discuss how the genomes, unique biologies, and interactions of both host and pathogen are being revealed using novel genomic technologies, and how this information can and will translate into disease management and therapies. This conference will engage basic and clinical scientists, including human geneticists, genome scientists, computational biologists, and experts in pathogenic microbial agents to chart the effects of genomics on questions in global infectious disease management.