Recommended Readings: Gabriel Victora, Ph.D., March 9

Special Lecture
Monday, March 9, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gabriel Victora, Ph.D.
Principal Investigator,
Whitehead Fellow,
Whitehead Institute for Biomedical Research

Darwin in Miniature: Antibody Evolution in Germinal Centers

Recommended Readings

Empirical Articles

Schwickert, T. a, Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., … Nussenzweig, M. C. (2011). A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. The Journal of Experimental Medicine, 208(6), 1243–1252. doi:10.1084/jem.20102477

Shulman, Z., Gitlin, A. D., Targ, S., Jankovic, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013). T follicular helper cell dynamics in germinal centers. Science, 341(6146), 673–677. doi:10.1126/science.1241680

Victora, G. D., Dominguez-sola, D., Holmes, A. B., Deroubaix, S., Dalla-favera, R., & Nussenzweig, M. C. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood, 120(11), 2240–2248. doi:10.1182/blood-2012-03-415380.

Victora, G. D., Schwickert, T. a., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010). Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell, 143(4), 592–605. doi:10.1016/j.cell.2010.10.032

Review Papers

Victora, G. D., & Mesin, L. (2014). Clonal and cellular dynamics in germinal centers. Current Opinion in Immunology, 28, 90-96. doi:10.1016/j.coi.2014.02.010

Victora, G. D., & Nussenzweig, M. C. (2012). Germinal Centers. Annual Review of Immunology, 30, 429-457. doi:10.1146/annurev-immunol-020711-075032

Recommended Readings: Jeffrey V. Ravetch, Ph. D.

Friday Lecture Series

The Paradox of Immunity

Jeffrey V. Ravetch, M.D., Ph.D., Theresa and Eugene M. Lang Professor and head,

Leonard Wagner Laboratory of Molecular Genetics and Immunology,

The Rockefeller University

March 9, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings:

Anthony, R. M., F. Nimmerjahn, D. J. Ashline, V. N. Reinhold, J. C. Paulson, and J. V. Ravetch. 2008. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG fc. Science 320, (5874): 373-376

Durandy, A., S. V. Kaveri, T. W. Kuijpers, M. Basta, S. Miescher, J. V. Ravetch, and R. Rieben. 2009. Intravenous immunoglobulins-understanding properties and mechanisms. Clinical and experimental immunology 158, (SUPPL. 1): 2-13

Nimmerjahn, F., and J. V. Ravetch. 2010. Antibody-mediated modulation of immune responses. Immunological reviews 236, (1): 265-275

Ravetch, J. 2010. In vivo veritas: The surprising roles of fc receptors in immunity. Nature immunology 11, (3): 183-185

Sazinsky, S. L., R. G. Ott, N. W. Silver, B. Tidor, J. V. Ravetch, and K. D. Wittrup. 2008. Aglycosylated immunoglobulin G1 variants productively engage activating fc receptors. Proceedings of the National Academy of Sciences of the United States of America 105, (51): 20167-20172