Tag Archives: immunity

Recommended Readings: Yanick Crow, PhD September 17, 2012

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Human Type I Interferonopathies

Yanick Crow  PhD

Professor of Genetic Medicine

University of Manchester, UK

Monday, September 17,  2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Review:

Banchereau, J; Pascual, V.  2006.  Type I interferon in systemic lupus erythematosus and other autoimmune diseases.   IMMUNITY.   25( 3):383-392.      DOI: 10.1016/j.immuni.2006.08.010

Recommended Readings:

Crow, Y.  2011.  Type I interferonopathies: a novel set of inborn errors of immunity.  Annals of the New York Academy of Sciences   1238: 91-98.     DOI: 10.1111/j.1749-6632.2011.06220.x

Briggs, Tracy A.; Rice, Gillian I.; Daly, Sarah; et al.   2011. Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. NATURE GENETICS  43(2):127-U71.     DOI: 10.1038/ng.748

 

Alcais, A; Quintana-Murci, L; Thaler, DS.; et al.  2010.  Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?  Annals of the New York Academy of Sciences    1214:18-33.     DOI: 10.1111/j.1749-6632.2010.05834.x

Crow, Yanick J. 2011. Lupus: How much “complexity” is really (just) genetic heterogeneity?  ARTHRITIS AND RHEUMATISM.   63(12): 3661-3664    DOI: 10.1002/art.30603

 

Crow, Y.; Rehwinkel, J.  2009.  Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.  HUMAN MOLECULAR GENETICS  18: R130-R136.    DOI: 10.1093/hmg/ddp293

Baechler, EC; Batliwalla, FM; Karypis, G; et al. 2003.  Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   100( 5):2610-2615.   DOI: 10.1073/pnas.0337679100

 

 

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Recommended Readings: Jason Cyster, Ph.D.

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Friday Lecture Series

Sphingolipids and Oxysterols in B Cell Immunity and Cancer

Jason Cyster, Ph.D., Professor, Department of Microbiology and Immunology,

University of California, San Francisco

March 16, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings:

Cinamon, G., M. A. Zachariah, O. M. Lam, F. W. Foss Jr., and J. G. Cyster. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nature immunology 9, (1): 54-62

Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annual Review of Immunology 23 , pp. 127-159

Okada, T., and J. G. Cyster. 2006. B cell migration and interactions in the early phase of antibody responses. Current opinion in immunology 18, (3): 278-285

Pappu, R., S. R. Schwab, I. Cornelissen, J. P. Pereira, J. B. Regard, Y. Xu, E. Camerer, et al. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, (5822): 295-298

Pham, T. H. M., P. Baluk, Y. Xu, I. Grigorova, A. J. Bankovich, R. Pappu, S. R. Coughlin, D. M. McDonald, S. R. Schwab, and J. G. Cyster. 2010. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. Journal of Experimental Medicine 207, (1): 17-27

Randall, K. L., T. Lambe, A. Johnson, B. Treanor, E. Kucharska, H. Domaschenz, B. Whittle, et al. 2009. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nature immunology 10, (12): 1283-1291

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Recommended Readings: Jeffrey V. Ravetch, Ph. D.

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Friday Lecture Series

The Paradox of Immunity

Jeffrey V. Ravetch, M.D., Ph.D., Theresa and Eugene M. Lang Professor and head,

Leonard Wagner Laboratory of Molecular Genetics and Immunology,

The Rockefeller University

March 9, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings:

Anthony, R. M., F. Nimmerjahn, D. J. Ashline, V. N. Reinhold, J. C. Paulson, and J. V. Ravetch. 2008. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG fc. Science 320, (5874): 373-376

Durandy, A., S. V. Kaveri, T. W. Kuijpers, M. Basta, S. Miescher, J. V. Ravetch, and R. Rieben. 2009. Intravenous immunoglobulins-understanding properties and mechanisms. Clinical and experimental immunology 158, (SUPPL. 1): 2-13

Nimmerjahn, F., and J. V. Ravetch. 2010. Antibody-mediated modulation of immune responses. Immunological reviews 236, (1): 265-275

Ravetch, J. 2010. In vivo veritas: The surprising roles of fc receptors in immunity. Nature immunology 11, (3): 183-185

Sazinsky, S. L., R. G. Ott, N. W. Silver, B. Tidor, J. V. Ravetch, and K. D. Wittrup. 2008. Aglycosylated immunoglobulin G1 variants productively engage activating fc receptors. Proceedings of the National Academy of Sciences of the United States of America 105, (51): 20167-20172

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Immune System Assassin: Perforin in Action

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The first observations that the human immune system could punch holes in target cells was made by the Nobel Laureate Jules Bordet over 110 years ago, but we have had to wait for the latest advances in structural molecular biology to find out how exactly this happens.  Scientists from the UK and Australia have seen the human immune system’s assassin — a protein called perforin — in action for the first time.   

Another interesting finding is that the important parts of the perforin molecule are quite similar to those toxins deployed by bacteria such as anthrax, listeria and streptococcus, showing that this method of making holes in cell membranes is quite ancient in evolution.

Perforin is also the culprit when the wrong cells are marked for elimination, either in autoimmune disease conditions, such as early onset diabetes, or in tissue rejection following bone marrow transplantation.

The research was published  October 31 in Nature.

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