Recommended Readings: Robert G. Roeder, Ph.D., November 16th

Monday Lecture Series
Monday, November 16, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Robert G. Roeder, Ph.D.
Arnold and Mabel Beckman Professor and Head,
Laboratory of Biochemistry and Molecular Biology,
The Rockefeller University

Transcriptional Regulatory Mechanisms in Animal Cells

Recommended Readings

Cevher, M. A., Shi, Y., Li, D., Chait, B. T., Malik, S., & Roeder, R. G. (2014). Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit. Nature Structural & Molecular Biology, 21(12), 1028-34. doi: 10.1038/nsmb.2914

Deshpande, A. J., Deshpande, A., Sinha, A. U., Chen, L., Chang, J., Cihan, A., … & Armstrong, S. A. (2014). AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell, 26(6), 896-908. doi: 10.1016/j.ccell.2014.10.009

Iida, S., Chen, W., Nakadai, T., Ohkuma, Y., & Roeder, R. G. (2015). PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1. Genes & Development, 29(3), 308-321. doi:10.1101/gad.252809.114

Sabari, B. R., Tang, Z., Huang, H., Yong-Gonzalez, V., Molina, H., Kong, H. E., … & Allis, C. D. (2015). Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation. Molecular Cell, 58(2), 203-215. doi:10.1016/j.molcel.2015.02.029

Zhang, P., Tu, B., Wang, H., Cao, Z., Tang, M., Zhang, C., … & Zhu, W. G. (2014). Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proceedings of the National Academy of Sciences, 111(29), 10684-10689. doi:10.1073/pnas.1411026111

Recommended Readings: Mitchell Guttman; March 25, 2009

Special Seminar Series

Large Intergenic ncRNAs in the Mammalian Genome:

From Discovery to Mechanism

Mitchell Guttman

Graduate fellow, Department of Biology

Broad Institute of MIT and Harvard/Massachusetts Institute of Technology

Wednesday, March 25, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Guttman, M., I. Amit, M. Garber, C. French, M. F. Lin, D. Feldser, M. Huarte, et al. 2009. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature, in press.

Guttman, M., C. Mies, K. Dudycz-Sulicz, S. J. Diskin, D. A. Baldwin, C. J. Stoeckert Jr., and G. R. Grant. 2007. Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays. PLoS Genetics. 3(8)e143.

Clamp, M., B. Fry, M. Kamal, X. Xie, J. Cuff, M. F. Lin, M. Kellis, K. Lindblad-Toh, and E. S. Lander. 2007. Distinguishing protein-coding and noncoding genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 104(49):19428-19433.

Willingham, A. T., A. P. Orth, S. Batalov, E. C. Peters, B. G. Wen, P. Aza-Blanc, J. B. Hogenesch, and P. G. Schultz. 2005. Molecular biology: A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science. 309(5740):1570-1573.

Rinn, J. L., M. Kertesz, J. K. Wang, S. L. Squazzo, X. Xu, S. A. Brugmann, L. H. Goodnough, et al. 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129(7):1311-1323.

Ponjavic, J., C. P. Ponting, and G. Lunter. 2007. Functionality or transcriptional noise? evidence for selection within long noncoding RNAs. Genome Research. 17(5):556-565.