Recommended Readings: Robert McGinty, M.D., Ph.D., February 18th

Special Lecture,
Wednesday, February 18th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Robert McGinty, M.D., Ph.D.
Damon Runyun Postdoctoral Fellow,
Dale F. Frey Breakthrough Scientist,
Department of Biochemistry & Molecular Biology,
The Pennsylvania State University

Chemistry, Crystallography and Nucleosome Ubiquitylation

Recommended Readings

Empirical Articles

Kim, J., Kim, J., McGinty, R. K., Nguyen, U. T., Muir, T. W., Allis, C. D., & Roeder, R. G. (2013). The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell, 49(6), 1121-1133. doi:10.1016/j.molcel.2013.01.034

McGinty, R. K., Henrici, R. C., & Tan, S. (2014). Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514(7524), 591-596. doi:10.1038/nature13890

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T., Kim, J., Sun, X. J., … & Roeder, R. G. (2013). SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2), 297-310. doi:10.1016/j.cell.2013.06.027

Review Papers

McGinty, R. K., & Tan, S. (In Press). Nucleosome structure and function. Chemical Reviews. doi:10.1021/cr500373h

The Fates of Embryonic Cells Indicated by Epigenetic Markers

Discovering the step-by-step details of the path embryonic cells take to develop into their final tissue type is the clinical goal of many stem cell biologists. To that end, Kenneth S. Zaret, PhD, professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, and associate director of the Penn Institute for Regenerative Medicine, and Cheng-Ran Xu, PhD, a postdoctoral researcher in the Zaret laboratory, looked at immature cells called progenitors and found a way to potentially predict their fate. They base this on how histones are marked by other proteins.  Read about this research in the May 20, 2011 issue of SCIENCE.

Studying Yeast to Better Understand Male Infertility

ScienceDaily (Aug. 17, 2010) — Men and yeast have something in common: they use the same molecular process to ensure the integrity of their gene pool during reproduction. This is a recent finding by researchers from CNRS, Inserm and the Université Joseph Fourier in Grenoble, whose scientists are studying yeast in order to shed light on the numerous cases of male infertility related to the malfunction of this process during spermatogenesis.  

Over the last fifty years, male fertility has declined steadily. Men are thought to have lost half their spermatozoa in half a century, probably because of pollutants. But the fragility of the remaining spermatozoa is also responsible for this situation.   Read the research on the functional dynamics of histones in gametogenesis in Genes and Development.

Related Readings – Yang Shi, PH.D.

Special Seminar Series: Biology of Single Cells

Histone Demethylases and Dynamic Regulation of Histone Methylation

Welch Hall Level 2 Wednesday February 27  4 p.m.



Recommended Review Article:

Shi, Yang, and J. R. Whetstine.  (2007) Dynamic regulation of histone lysine methylation by demethylases. Molecular Cell 25 :1-14

Related Articles:

Shi, Yang.  (2007)   Histone lysine demethylases: emerging roles in development, physiology and disease.  Nature Reviews Genetics  8 (11):829-833

Garcia-Bassets, Ivan et al.  (2007)  Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptorsCell  128 :505-518

Huang, Yi et al.   (2007)  Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silent genes.  PNAS 104: 8023-8028

Kloze, Robert J. , Eric Kallin, and Yi Zhang.  (2006)  JmjC-domain-containing proteins and histone demethylation.  Nature Review Genetics  7 :715-727

Margueron, Raphael, Patrick Trojer and Danny Reinberg.  (2005) The key to development: interpreting the histone code?  Current Opinion in Genetics and Development 15 :163-176