Recommended Readings: Stuart H. Orkin M.D. January 6 2017

Friday Lectures

Friday, January 6,  3:45 p.m.

Caspary Auditorium

Stuart H. Orkin   M.D.

David G. Nathan Distinguished Professor of Pediatrics, Dana Farber Institute

The Human Fetal Globin Switch:

A Paradigm for Disease-related Common Genetic Variation in Regulatory Elements

Recommended Readings:

Bauer, Daniel E.; Kamran, Sophia C.; Lessard, Samuel; et al.  An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level.  SCIENCE  342(6155): 253-257    OCT 11 2013  

Galarneau, Genevieve; Palmer, Cameron D.; Sankaran, Vijay G.; et al.  Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.  NATURE GENETICS   42(12): 1049-1051   DEC 2010

Menzel, Stephan; Thein, Swee Lay.   Genetic architecture of hemoglobin F control. CURRENT OPINION IN HEMATOLOGY   16(3): 179-186   MAY 2009  PLEASE REQUEST FROM MARKUS LIBRARY

He, Yunyan; Lin, Weixiong; Luo, Jianming.  Influences of Genetic Variation on Fetal Hemoglobin. PEDIATRIC HEMATOLOGY AND ONCOLOGY   Volume: 28   Issue: 8   Pages: 708-717   Published:  NOV 2011   PLEASE REQUEST FROM MARKUS LIBRARY.

Orkin, Stuart H.  Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences   1368 : 5-10    2016