Recommended Readings: David Kingsley, Ph.D.

Friday Lecture Series

The Fairfield Osborn Memorial Lecture

Fishing for the Secrets of Vertebrate Evolution

David Kingsley, Ph.D., professor, developmental biology, Stanford University;

investigator, Howard Hughes Medical Institute

April 18, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

han, Y. F., Marks, M. E., Jones, F. C., Villarreal Jr., G., Shapiro, M. D., Brady, S. D., . . . Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer. Science, 327(5963), 302-305

Haussler, D., O’Brien, S. J., Ryder, O. A., Keith Barker, F., Clamp, M., Crawford, A. J., . . . Turner, S. (2009). Genome 10K: A proposal to obtain whole-genome sequence for 10000 vertebrate species. Journal of Heredity, 100(6), 659-674

Jones, F. C., Grabherr, M. G., Chan, Y. F., Russell, P., Mauceli, E., Johnson, J., . . . Kingsley, D. M. (2012). The genomic basis of adaptive evolution in threespine sticklebacks. Nature, 484(7392), 55-61

Kingsley, D. M., Zhu, B., Osoegawa, K., De Jong, P. J., Schein, J., Marra, M., . . . Myers, R. (2004). New genomic tools for molecular studies of evolutionary change in threespine sticklebacks. Behaviour, 141(11-12), 1331-1344

Lowe, C. B., Kellis, M., Siepel, A., Raney, B. J., Clamp, M., Salama, S. R., . . . Haussler, D. (2011). Three periods of regulatory innovation during vertebrate evolution. Science, 333(6045), 1019-1024

Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006). Parallel genetic origins of pelvic reduction in vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 103(37), 13753-13758


Recommended Readings: Talking Science, Monday, December 30

Talking Science
Caspary Auditorium
Monday, December 30, 2013
10:30 a.m.-2:30 p.m.

C. David Allis, Ph.D.
Joy and Jack Fishman Professor
Laboratory of Chromatin Biology and Epigenetics
The Rockefeller University

Epigenetics: Inheriting More Than Genes

Recommended Reading:

Epigenetics Basics

Simmons, D. (2008) Epigenetic influence and diseaseNature Education 1(1):6

In-Depth Reading

Feinberg, A. P. (2008). Epigenetics at the epicenter of modern medicine. JAMA : The Journal of the American Medical Association, 299(11), 1345–1350. doi:10.1001/jama.299.11.1345

Goldberg, A. D., Allis, C. D., & Bernstein, E. (2007). Epigenetics: a landscape takes shape. Cell, 128(4), 635–638. doi:10.1016/j.cell.2007.02.006

Recommended Readings: Hopi Hoekstra, Ph.D.

Friday Lecture Series

From Darwin to DNA: The Genetic Basis of Adaptive Morphology and Behavior

Hopi Hoekstra, Ph.D., Alexander Agassiz Professor of Zoology,

curator of mammals, Museum of Comparative Zoology,

Harvard University

February 24, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Abzhanov, A., C. G. Extavour, A. Groover, S. A. Hodges, H. E. Hoekstra, E. M. Kramer, and A. Monteiro. 2008. Are we there yet? tracking the development of new model systems. Trends in Genetics 24, (7): 353-360

Barrett, R. D. H., and H. E. Hoekstra. 2011. Molecular spandrels: Tests of adaptation at the genetic level. Nature Reviews Genetics 12, (11): 767-780

Hoekstra, H. E. 2006. Genetics, development and evolution of adaptive pigmentation in vertebrates. Heredity 97, (3): 222-234

Hoekstra, H. E., and J. A. Coyne. 2007. The locus of evolution: Evo devo and the genetics of adaptation. Evolution 61, (5): 995-1016

Stinchcombe, J. R., and H. E. Hoekstra. 2008. Combining population genomics and quantitative genetics: Finding the genes underlying ecologically important traits. Heredity 100, (2): 158-170

The Value of Genetic and Genomic Technologies Workshop

The National Institute of Medicine of the National Academies of Science will hold a workshop on March 22, 2010 exploring the value of genetic and genomic technologies.   Click here to register for this meeting.
When:  March 22, 2010 (8:00 AM)
Where: Beckman Center • 100 Academy Drive, Irvine, CA 92617
Topics:    Biomedical and Health Research, Public Health
Activity: Roundtable on Translating Genomic-Based Research for Health
Board:      Board on Health Sciences Policy

A public workshop will be held to examine the perceived value of genetic and genomic technologies, both present and future, in clinical practice from different stakeholder perspectives.

This workshop will build on the concepts of clinical utility, personal utility, public utility, and economic value, and explore these different types of value through questions such as:  

-How do different stakeholders define the value of genetic and genomic technologies?   

-How do stakeholders evaluate the weight of one kind of value in relation to another? 

-How do people assess relative values to make health care decisions?

-How do these types of value relate, or not relate, to the monetary cost of the technologies? 

Presentations and discussions will explore the concept of value in regards to genomics and genetics, and how it affects the view of stakeholders and the way they make decisions about using these technologies. Stakeholders, including patients, payers, policy makers, and others will present their perspectives.