Recommended Readings: Kivanc Birsoy, Ph.D., January 14

Special Lecture
Friday, January 14, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Kivanc Birsoy, Ph.D.
Jane Coffin Childs Medical Fund Fellow,
Whitehead Institute for Biomedical Research
Broad Institute of Harvard and MIT

Systematic Approaches to Study Metabolic Plasticity of Cancer Cells

Recommended Readings

Empirical Articles

Birsoy, K., Possemato, R., Lorbeer, F. K., Bayraktar, E. C., Thiru, P., Yucel, B., … Sabatini, D. M. (2014). Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature, 508(7494), 108–112. doi:10.1038/nature13110

Birsoy, K., Wang, T., Possemato, R., Yilmaz, O. H., Koch, C. E., Chen, W. W., … Sabatini, D. M. (2013). MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics, 45(1), 104–108. doi:10.1038/ng.2471

Grabiner, B. C., Nardi, V., Birsoy, K., Possemato, R., Shen, K., Sinha, S., … Sabatini, D. M. (2014). A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery, 4(5), 554–563. doi:10.1158/2159-8290.CD-13-0929

Review Papers

Birsoy, K., Sabatini, D. M., & Possemato, R. (2012). Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine, 18(7), 1022–1023. doi:10.1038/nm.2870

Related Readings: Leonid Kruglyak PhD

Special Seminar Series:  Systems Biology

Learning C. elegans Biology from Natural Genetic Variation

Leonid Kruglyak, Ph.D.

Professor of Ecology and Evolutionary Biology

Lewis-Sigler Institute for Integrative Genomics

Princeton University

Welch Hall, Level 2  4:00 p.m   Refreshments: 3:45 

Recommended Articles:

Zhu, Jun; Zhang, Bin; Smith, Erin N.; Drees, Becky; brem, Rachel B.; Krulyak, Leonid; Bumgarner, Roger E.; Schadt, Eric E.  2008.  Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.  Nature Genetics.   40(7): 854-861.


Smith, Erin N.; Kruglyak, Leonid.  2008.  Gene-environment interaction in yeast gene expression. PLoS Biology.  6(4):e83


Seidel, Hannah S.; Rockman, Matthew V.; Kruglyak, Leonid.  2008.  Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science   319 (5863): 589-594


Rockman, Matthew V.; Kruglyak, Leonid.  2006. Genetics of global gene expression.  Nature Reviews Genetics.  7(11):862-872.


Kroymann, Juergen; Mitchell-Olds, Thomas.  2005.  Epistasis and balanced polymorphism influencing complex trait variation.  Nature  435(7038): 95-98.


Wright, Stephen I.; Gaut, Brandon S.  2005.  Molecular population genetics and the search for adaptive evolution in plants.  Molecular Biology and Evolution.  22(3):505-519