Recommended Readings: Frederick Cross Ph.D. Monday December 5, 2016

Monday Lectures

 December 5, 2016

4:00 p.m.  Carson Family Auditorium  CRC

Frederick Cross  Ph.D.

Professor,  Laboratory of Cell Cycle Genetics

The Rockefeller University

Evolution of Cell Cycle Control:

Branches and a Green Microbe

Recommended Readings:

Tulin, Frej; Cross, Frederick R.  Patching Holes in the Chlamydomonas Genome.  G3-GENES GENOMES GENETICS   6(7): 1899-1910   JUL 1 2016

Onishi, Masayuki; Pringle, John R.; Cross, Frederick R.   Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas.  GENETICS    202(30): 977-+  MAR 2016

Tulin, Frej; Cross, Frederick R.   A Microbial Avenue to Cell Cycle Control in the Plant Superkingdom.   PLANT CELL   26(10): 4019-4038     OCT 2014

Cross, Frederick R.; Umen, James G.  The Chlamydomonas cell cycle   PLANT JOURNAL   82(3): 370-392   MAY 2015

Recommended Readings: Michael O’Donnell Ph.D. Monday December 12, 2016

Monday Lectures

 December 12, 2016

4:00 p.m.  Carson Family Auditorium  CRC

Michael O’Donnell  Ph.D.

HHMI Investigator, and Anthony and Judith Evnin Professor
Laboratory of DNA Replication

The Rockefeller University

The Eukaryotic Replisome

Recommended Readings:

O’Donnell, Mike; Li, Huilin   The Eukaryotic Replisome Goes Under the Microscope.  CURRENT BIOLOGY  26(6): R247-R256      MAR 21 2016

Yuan, Zuanning; Bai, Lin; Sun, Jingchuan; et al.   Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.  NATURE STRUCTURAL & MOLECULAR BIOLOGY   23(3): 217-224     MAR 2016

Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E.; et al.   The architecture of a eukaryotic replisome.   NATURE STRUCTURAL & MOLECULAR BIOLOGY    22(12): 976-982 DEC 2015

Georgescu, Roxana E.; Schauer, Grant D.; Yao, Nina Y.; et al.  Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.      ELIFE    4: e04988     APR 14 2015

O’Donnell, Michael; Langston, Lance; Stillman, Bruce  Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya .   COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY    5(7): a010108

Recommended Readings: Harmit S. Malik, Ph.D.

Friday Lecture Series

Genetic Conflicts: Beyond the Usual Suspects

Harmit S. Malik, Ph.D., principal investigator, basic sciences division,

Fred Hutchinson Cancer Research Center;

early career scientist, Howard Hughes Medical Institute

December 13, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Malik, H. S. (2009). Evolution of TRIM antiviral genes in primate genomes. Retrovirology, 6(SUPPL. 2)

Malik, H. S., & Bayes, J. J. (2006). Genetic conflicts during meiosis and the evolutionary origins of centromere complexity. Biochemical Society Transactions, 34(4), 569-573

Malik, H. S., & Henikoff, S. (2002). Conflict begets complexity: The evolution of centromeres. Current Opinion in Genetics and Development, 12(6), 711-718

Moran, J. V., & Malik, H. S. (2009). Diamonds and rust: How transposable elements influence mammalian genomes. conference on mobile elements in mammalian genomes. EMBO Reports, 10(12), 1306-1310

Oliver, P. L., Goodstadt, L., Bayes, J. J., Birtle, Z., Roach, K. C., Phadnis, N., . . . Ponting, C. P. (2009). Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genetics, 5(12)

Vermaak, D., & Malik, H. S. (2009). Multiple roles for heterochromatin protein 1 genes in drosophila. Annual Review of Genetic 43 , pp. 467-492

 

Recommended Readings: Roderick MacKinnon, M.D.

Friday Lecture Series

Inaugural Bruce Merrifield Distinguished Lecture; Ph.D. Recruitment Lecture

The Incredible Diversity of K+ Channels

Roderick MacKinnon, M.D., John D. Rockefeller Jr. Professor, and head,

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University;

investigator, Howard Hughes Medical Institute

 March 1, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Hansen, S. B., Tao, X., & MacKinnon, R. (2011). Structural basis of PIP 2 activation of the classical inward rectifier K + channel Kir2.2. Nature, 477(7365), 495-498

Lee, S. -., Banerjee, A., & MacKinnon, R. (2009). Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K + channels. PLoS Biology, 7(3)

Lee, S. -., Lee, A., Chen, J., & MacKinnon, R. (2005). Structure of the KvAP voltage-dependent K + channel and its on the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15441-15446

Long, S. B., Tao, X., Campbell, E. B., & MacKinnon, R. (2007). Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature, 450(7168), 376-382

Schmidt, D., & MacKinnon, R. (2008). Voltage-dependent K + channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19276-19281

Tao, X., Avalos, J. L., Chen, J., & MacKinnon, R. (2009). Crystal structure of the eukaryotic strong inward-rectifier K + channel Kir2.2 at 3.1 Å resolution. Science, 326(5960), 1668-1674

 

Recommended Readings: Paul Nurse, PhD May 18, 2009

Monday Lecture Series

“Controlling the Eukaryotic Cell Cycle”

Paul Nurse, PhD

President, The Rockefeller University

May 18, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)  

Second Floor, Welch Hall

 

 

Review Articles:

Nelson, B; Kurischeko, C; Horecka, J. et al.  2003.  RAM: A conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis.  Molecular Biology of the Cell.  14(9):3782-3803

Hasan S;  Hassa, PO;  Imhof, R. et al. 2001.  Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.  Nature. 410(6826):387-391  

 

Recommended Articles:

Bottcher, RT; Wiesner, S; Braun, A. et al.  2009.   Profilin 1 is required for abscission during late cytokinesis of chondrocytes.  EMBO Journal. 28(8):1157-1169

Neumann, FR; Nurse, P.  2007.  Nuclear size control in fission yeast.  Journal of Cell Biology. 179(4):593-600

 Drewes, G; Nurse, P.  2003.  The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important to bipolar growth.  FEBS Letters. 554(1-2):45-49

Arellano, M; Niccoli, T; Nurse, P.  2002.  Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe. Current Biology. 12(9):751-756

Hirata, D; Kishimoto, N; Suda, M. et al.  2002.  Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G92) delay.   EMBO Journal.   21(18):4863-4874 

Bahler, J; Nurse, P.  2001.  Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division. EMBO Journal. 20(5):1064-1073 

Browning, H.; Hayles, J; Mata, J. et al.   2000.  Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.  Journal of Cell Biology.  151(1):15-27 

Sawin, KE; Hajibacheri, M.A.Nassar; Nurse, P.  1999.  Mis-specification of cortical identity in a fission yeast PAK mutant.  Current  Biology. 9(22):1335-1338

Chang, F; Drubin, D; Nurse, P.  1997.  cdc12p, a protein require for cytokinesis in fission yeast, is a component of  the cell divisions ring and interacts with profiling. Journal of Cell Biology.  137(1):169-182