Recommended Readings: Lydia Finley, Ph.D., March 30

Special Lecture
Wednesday, March 30
4:00 p.m., Carson Family Auditorium (CRC)

Lydia Finley, Ph.D.
Jack Sorrell Fellow,
Damon Runyon Cancer Research Foundation,
Cancer Biology and Genetics Program,
Memorial Sloan Kettering Cancer Center

Metabolic Regulation of Cell Fate Decisions

Recommended Readings

Carey, B. W., Finley, L. W., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015). Intracellular [agr]-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature, 518(7539), 413-416.  doi: 10.1038/nature13981.

Intlekofer, A. M., Dematteo, R. G., Venneti, S., Finley, L. W., Lu, C., Judkins, A. R., … & Thompson, C. B. (2015). Hypoxia induces production of L-2-hydroxyglutarate, Cell Metabolism, 22(2), 304-311. doi: 10.1016/j.cmet.2015.06.023.

Jeong, S. M., Xiao, C., Finley, L. W., Lahusen, T., Souza, A. L., Pierce, K., … & Xu, X. (2013). SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell, 23(4), 450-463. doi: 10.1016/j.ccr.2013.02.024.

Laurent, G., de Boer, V. C., Finley, L. W., Sweeney, M., Lu, H., Schug, T. T., … & Haigis, M. C. (2013). SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Molecular and Cellular Biology, 33(22), 4552-4561. doi: 10.1128/MCB.00087-13.

Recommended Readings: Rudolf Jaenisch, M.D. December 12

Friday Lecture Series
Friday, December 12, 2014
3:45 p.m., Caspary Auditorium

Rudolf Jaenisch, M.D.
Professor of Biology,
Massachusetts Institute of Technology
Whitehead Institute for Biomedical Research

iPS Cell Technology, Gene Editing and Disease Research

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Li, Y., Wang, H., Muffat, J., Cheng, A. W., Orlando, D. a, Lovén, J., … Jaenisch, R. (2013). Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell, 13(4), 446–458. doi:10.1016/j.stem.2013.09.001

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., … Jaenisch, R. (2011). Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell, 146(2), 318–331. doi:10.1016/j.cell.2011.06.019

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013). One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell, 153(4), 910–918. doi:10.1016/j.cell.2013.04.025

Review Papers

Buganim, Y., Faddah, D. A., & Jaenisch, R. (2013). Mechanisms and models of somatic cell reprogramming. Nature Reviews Genetics, 14(6), 427–439. doi:10.1038/nrg3473

Theunissen, T. W., & Jaenisch, R. (2014). Molecular Control of Induced Pluripotency. Cell Stem Cell, 14(6), 720–734. doi:10.1016/j.stem.2014.05.002

Recommended Readings: Ali H. Brivanlou, Ph.D. November 24

Monday Lecture Series
Monday, November 24, 2014
4:00 p.m., Carson Family Auditorium

Ali H. Brivanlou, Ph.D.
Robert and Harriet Heilbrunn Professor and Head,
Laboratory of Stem Cell Biology and Molecular Embryology,
The Rockefeller University

Dynamic Patterns: Self-Organization of Human Embryonic Cells

Recommended Readings

Empirical Articles

Arduini, B., & Brivanlou, A. (2012). Modulation of FOXD3 activity in human embryonic stem cells directs pluripotency and paraxial mesoderm fates. Stem Cells, 30(10), 2188–2198. doi:10.1002/stem.2012

Ozair, M., Noggle, S., & Warmflash, A. (2013). SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism. Stem Cells, 31(1), 35–47. doi:10.1002/stem.1246.SMAD7

Rosa, A., Papaioannou, M. D., Krzyspiak, J. E., & Brivanlou, A. H. (2014). miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human embryonic stem cells. Developmental Biology, 391(1), 81–88. doi:10.1016/j.ydbio.2014.03.020

Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D., & Brivanlou, A. H. (2014). A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nature Methods, 11(8). doi:10.1038/nmeth.3016

Review Article

Muñoz-Sanjuán, I., & Brivanlou, A. H. (2002). Neural induction, the default model, and embryonic stem cells. Nature Reviews Neuroscience, 3(4), 271–280. doi:10.1038/nrn786