Recommended Readings: Gerry Rubin, Ph.D.

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

A Molecular Geneticist’s Approach to Understanding the Fly Brain

Gerry Rubin, Ph.D., vice president and executive director,

Howard Hughes Medical Institute Janelia Farm Research Campus

October 19, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Aboobaker, A. A., Tomancak, P., Patel, N., Rubin, G. M., & Lai, E. C. (2005). Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18017-18022

Ashburner, M., Misra, S., Roote, J., Lewis, S. E., Blazej, R., Davis, T., . . . Rubin, G. M. (1999). An exploration of the sequence of a 2.9-mb region of the genome of drosophila melanogaster: The adh region. Genetics, 153(1), 179-219

Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., . . . Spradling, A. C. (2004). The BDGP gene disruption project: Single transposon insertions associated with 40% of drosophila genes. Genetics, 167(2), 761-781

Miklos, G. L. G., & Rubin, G. M. (1996). The role of the genome project in determining gene function: Insights from model organisms. Cell, 86(4), 521-529

Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T. -. B., Misra, S., Murphy, C., . . . Rubin, G. M. (2008). Tools for neuroanatomy and neurogenetics in drosophila. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9715-9720

Pfeiffer, B. D., Ngo, T. -. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010). Refinement of tools for targeted gene expression in drosophila. Genetics, 186(2), 735-755


Recommended Readings: Anne Ephrussi, Ph.D.

Friday Lecture Series

RNP Assembly and Transport in the Drosophila Oocyte

Anne Ephrussi, Ph.D., head, Developmental Biology Unit and head,

International Center for Advanced Training,

European Molecular Biology Laboratory

April 20, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Chekulaeva, M. and A. Ephrussi. 2004. “Drosophila Development: RNA Interference Ab Ovo.” Current Biology 14 (11): R428-R430

Hachet, O. and A. Ephrussi. 2001. “Drosophila Y14 Shuttles to the Posterior of the Oocyte and is Required for Oskar mRNA Transport.” Current Biology 11 (21): 1666-1674

Jambor, H., C. Brunel, and A. Ephrussi. 2011. “Dimerization of Oskar 3′ UTRs Promotes Hitchhiking for RNA Localization in the Drosophila Oocyte.” RNA 17 (12): 2049-2057

Krauss, J., S. López de Quinto, C. Nüsslein-Volhard, and A. Ephrussi. 2009. “Myosin-V Regulates Oskar mRNA Localization in the Drosophila Oocyte.” Current Biology 19 (12): 1058-1063

Vanzo, N., A. Oprins, D. Xanthakis, A. Ephrussi, and C. Rabouille. 2007. “Stimulation of Endocytosis and Actin Dynamics by Oskar Polarizes the Drosophila Oocyte.” Developmental Cell 12 (4): 543-555

Vanzo, N. F. and A. Ephrussi. 2002. “Oskar Anchoring Restricts Pole Plasm Formation to the Posterior of the Drosophila Oocyte.” Development 129 (15): 3705-3714

Recommended Readings: Hugo Bellen, Ph.D., D.V.M.

Friday Lecture Series

Mitochondria and Neurodegeneration

Hugo Bellen, Ph.D., D.V.M., investigator, Howard Hughes Medical Institute;

professor, departments of molecular and human

genetics and neuroscience, director, Program in Developmental Biology,

Baylor College of Medicine

March 30, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:


Han, S. M., H. Tsuda, Y. Yang, J. Vibbert, P. Cottee, S. -J Lee, J. Winek, C. Haueter, H. J. Bellen, and M. A. Miller. 2012. “Secreted VAPB/ALS8 Major Sperm Protein Domains Modulate Mitochondrial Localization and Morphology Via Growth Cone Guidance Receptors.” Developmental Cell 22 (2): 348-362

Pesah, Y., T. Pham, H. Burgess, B. Middlebrooks, P. Verstreken, Y. Zhou, M. Harding, H. Bellen, and G. Mardon. 2004. “Drosophila Parkin Mutants have Decreased Mass and Cell Size and Increased Sensitivity to Oxygen Radical Stress.” Development 131 (9): 2183-2194

Romero, E., G. -H Cha, P. Verstreken, C. V. Ly, R. E. Hughes, H. J. Bellen, and J. Botas. 2008. “Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm.” Neuron 57 (1): 27-40

Venken, K. J. T., Y. He, R. A. Hoskins, and H. J. Bellen. 2006. “P[Acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. Melanogaster.” Science 314 (5806): 1747-1751

Verstreken, P., C. V. Ly, K. J. T. Venken, T. -W Koh, Y. Zhou, and H. J. Bellen. 2005. “Synaptic Mitochondria are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions.” Neuron 47 (3): 365-378

Recommended Readings: Vanessa Ruta, Ph.D. April 11, 2011

Monday Lecture Series

From the Periphery Through the Protocerebrum: Tracing Olfactory Circuits in the Fly Brain

  Vanessa Ruta  Ph.D.

Associate Research Scientist

Department of Neuroscience, Columbia University

April 11, 2011

4 – 5 p.m.  Caspary Auditorium

Recommended Readings:

Hampbel, S; Chung, P; McKellar, CE, et al  2011.  Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns Nature Methods.  8(3):253-U102.

Ruta, V; Datta, SR; Vasconcelos, ML, et al.  2010.  A dimorphic pheromone circuit in Drosophila from sensory input to descending output.  Nature.  468:686-U106.

Imai, T; Sakano, H; Vosshall, LB.  2010.  Topographic mapping – the olfactory system.  Cold Spring Harbor Perspectives in Biology.  2(8):a001776

Touhara, K; Vosshall, LB.  2009.  Sensing odorants and pheromones with chemosensory receptors.  Annual Review of Physiology.  71:307-332.

Vosshall, LB.  2008.  Scent of a fly.  Neuron.  59(5): 685-689.

Datta, SR; Vasconcelos, ML; ruta, V. et al.  2008.  The Drosophila pheromone  cVA acticates a sexually dimorphic neural circuit.   Nature.  452(7186):473-477. 

Sachse, S; Rueckert, E; Keller, A, et al.  2007.  Activity-dependent plasticity in an olfactory circuit.   Neuron.  56(5):838-850.

Olsen, SR; Wilson, RI.  2008.  Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila.   Trends in Neurosciences.  31(10):512-520

Harvard’s Gary Ruvken Highlights Basic Research in Keynote to Genetics Society

In his keynote talk at the Genetics Society of America’s Genetics 2010: Model Organisms to Human Biology meeting in Boston this week, Harvard Medical School’s Gary Ruvkun spoke to the importance of basic research in model organisms — or “cardinal organisms,” as he prefers to call them. “The reason I don’t like ‘model organisms,'” he told the audience of geneticists, is because it “sounds like model airplanes — it just sounds tiny. … Comparative genomics is empowering human genomics and human genetics; we have to be much more aggressive as people who work on invertebrates and yeast and things.” Ruvkun suggests that those who study Drosophila genetics “have been the least aggressive” in staking their claim of advances in applied genetics which have had important clinical applications. Some oncologists, he said, “don’t know why it’s called ‘wingless.'”

“If we renamed it ‘cardinal organisms,’ that sounds much more important,” Ruvkun told attendees. “In navigation, you have these cardinal sites that tell you where to go” – which is appropriate because geneticists who study model systems are “really the beacons for genetic analysis” in humans,” he said.

Recommended Readings: Gaby Maimon, Ph.D. Feb 17 2010

Monday Lecture Series

Active Vision and Higher Brain Function in Drosophila melanogaster

Gaby Maimon, Ph.D.,

Post Doctoral Fellow, Division of Biology

California Institute of Technology

February 17, 2010

4:00p.m.-5:00 p.m.

Welch Hall, Level Two

Recommended Articles:

Maimon G, Straw AD, Dickinson MH.  2008.  A simple vision-based algorithm for decision making in flying Drosophila. CURRENT BIOLOGY 18(6): 464-470

Duistermars BJ, Chow DM, Frye MA.  2009.  Flies Require Bilateral Sensory Input to Track Odor Gradients in Flight. CURRENT BIOLOGY 19(15):1301-1307

Nordstrom K, O’Carroll DC.   2009.  Feature detection and the hypercomplex property in insects. TRENDS IN NEUROSCIENCES 32(7): 383-391

Yin Y, Chen NN, Zhang SX, et al.   2009.  Choice strategies in Drosophila are based on competition between olfactory memories. EUROPEAN JOURNAL OF NEUROSCIENCE 30(2): 279-288

Olsen SR, Wilson RI.   2008.  Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. TRENDS IN NEUROSCIENCES 31(10):512-520

Chow DM, Frye MA.  2008.  Context-dependent olfactory enhancement of optomotor flight control in Drosophila. JOURNAL OF EXPERIMENTAL BIOLOGY 211(15): 2478-2485

Recommended Readings: Michael Rosbash, Ph. D. Oct. 9, 2009

Friday Lecture Series

Circadian Rhythms and the Transcriptional Feedback Loop

Michael Rosbach, Ph. D., professor and director

National Center for Behavioral Genomics, Brandeis University;

Howard Hughes Medical Institute, investigator

October 9, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Kadener, S., J. S. Menet, K. Sugino, M. D. Horwich, U. Weissbein, P. Nawathean, V. V. Vagin, P. D. Zamore, S. B. Nelson, and M. Rosbash. 2009. A role for microRNAs in the drosophila circadian clock. Genes and Development 23, (18): 2179-219

Kadener, S., D. Stoleru, M. McDonald, P. Nawathean, and M. Rosbash. 2007. Clockwork orange is a transcriptional repressor and a new drosophila circadian pacemaker component. Genes and Development 21, (13): 1675-168

Rosbash, M. 2009. The implications of multiple circadian clock origins. PLoS Biology 7, (3): 0421-0425

Shang, Y., L. C. Griffith, and M. Rosbash. 2008. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the drosophila brain. Proceedings of the National Academy of Sciences of the United States of America 105, (50): 19587-19594

Stoleru, D., P. Nawathean, M. d. l. P. Fernández, J. S. Menet, M. F. Ceriani, and M. Rosbash. 2007. The drosophila circadian network is a seasonal timer. Cell 129, (1): 207-219

Recommended Readings: Sandeep R. Datta MD PhD

Monday Lecture Series

From Odors to Behavior: Visualizing Sensory Circuits in Flies and Mice

Sandeep Robert Datta  MD, PhD

Post-doctoral Fellow, Department of Neurobiology

Columbia University, New York

Monday, February 2, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Review Article:


Sato T,  Hirono J,  Hamana H, et al.  2008.  Architecture of odor information processing in the olfactory system.    Anatomical science international    83(4):195-206   



Recommended Readings:

Dickson BJ.  2008.  Wired for Sex: the neurobiology of Drosophila mating decisions .  Science  322(5903): 904-909


Katz DB, Matsunami H, Rinberg D, et al.  2008. Receptors, circuits, and behaviors: new directions in chemical senses.  Journal of neuroscience.   28(46): 11802-11805


Sambandan D, Carbone MA, Anholt RRH, et al.  2008. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster.
Genetics.   179(2):1079-1088   


Datta SR, Vasconcelos ML  Ruta V, et al.   2008.  The Drosophila pheromone cVA activates a sexually dimorphic neural circuit.   Nature (London). 452(7186):473-477


Schlief ML, Wilson RI.  2007.  Olfactory processing and behavior downstream from highly selective receptor neurons.  Nature Neuroscience.    10(5):623-630   


 Sambandan D, Yamamoto A, Fanara JJ, et al.  2006.  Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster.  Genetics.  174(3):1349-1363   







Recommended Readings: Edwin Ferguson, Ph.D.

Special Seminar Series: Evolution & Developmental Biology

Niche-associated Polarization of a Stem Cell in Drosophila

Edwin Ferguson, Ph.D.

Associate Professor, Department of Molecular Genetics and Cell Biology

The University of Chicago

Wednesday, January 21, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Casanueva, M. O., and E. L. Ferguson. 2004. Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control dpp signaling. Development. 131(9):1881-1890.

Bolivar, J., J. Pearson, L. Lopez-Onieva, and A. Gonzalez-Reyes. 2006. Genetic dissection of a stem cell niche: The case of the Drosophila ovary. Developmental Dynamics. 235(11):2969-2979.

Jin, Z., D. Kirilly, C. Weng, E. Kawase, X. Song, S. Smith, J. Schwartz, and T. Xie. 2008. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2(1):39-49.

Kirilly, D., and T. Xie. 2007. The Drosophila ovary: An active stem cell community. Cell Research. 17(1):15-25.

Wang, L., Z. Li, and Y. Cai. 2008. The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. Journal of Cell Biology. 180(4):721-728.

Dansereau, D. A., and P. Lasko. 2008. RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. Journal of Cell Biology. 182(5):963-977.

Kirilly, D., E. P. Spana, N. Perrimon, R. W. Padgett, and T. Xie. 2005. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental Cell. 9(5):651-662.

Song, X., M. D. Wong, E. Kawase, R. Xi, B. C. Ding, J. J. McCarthy, and T. Xie. 2004. Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development. 131(6):1353-1364.


Related Readings – David L. Stern, PhD

Special Seminar Series: Evolution, Ecology and Ethology

Dissecting the Genetic Causes of Morphological Differences Between Fly Species

Welch Hall Level 2 Wednesday February 6 4 p.m.

Recommended Review Article:

Frankino, W.A.; Zwaan, B.J.; Stern, D.L. and Brakefield, P.M. (2005) Natural selection and developmental constraints in the evolution of allometries. Science 307 (5710):718-720

Related Articles:

Orgogozo, V.; Muro, N.M.; Stern, D.L. (2007) Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysis. Evolution & Development 9 (4):368-377

McGregor, A. P.; Orgogozo, V.; Delon, I.; Zanet, J.; Srinivasen, D. G.; Payre, F.; Stern, D. L. (2007) Morphological evolution through multiple cis-regulatory mutations on a single gene. Nature 448 (7153):587-590

Kheradpour, P.; Stark, A.; Roy, S.; and Kellis, M. (2007) Reliable prediction of regulator targets using 12 Drosophila genomes. Genome Research 17 (12):1919-1931

Orgogozo, V.; Broman, K. W.; Stern, D. L. (2006) High-resolution quantitative trait locus mapping reveals epistasis controlling ovariole number between two Drosophila species. Genetics 173 (1) :197-205

Orgogozo, V.; Grueber, W.B. (2005) FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system. BMC Developmental Biology 5 (article 4)