Recommended Readings: Gaby Maimon, Ph.D., Sept 23, 2016

Friday Lecture Series

Head shot of Gaby Maimon

Gaby Maimon, Ph.D.

Assistant Professor
Laboratory of Integrative Brain Function

Quantitative Neural Computations in Behaving Drosophila

Recommended Readings:

Kim, A.J. et al. Cellular evidence for efference copy in Drosophila visuomotor processing. Nature Neuroscience. 18, 1247–1255 (2015).

Rien, D.; kern, R. and R. Kurtz.  Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.  Frontiers in Bahavioral Neuroscience. 7, 155 (2013)

Maimon, G. Modulation of visual physiology by behavioral state in monkeys, mice, and flies. Current Opinions in Neurobiology. 21, 559–564 (2011).

Rosner, R. and A. K. Warzecha.  Relating neuronal to behavioral performance: variability of optomotor responses in the blowflyPLoS One.   6, 10:e26886 (2011)

Recommended Readings: Vanessa Ruta, Ph.D., February 26

Friday Lecture Series
The Detlev W. Bronk Alumni Lecture, Ph.D. Recruitment Lecture
Friday, February 26
3:45 p.m., Caspary Auditorium

Vanessa Ruta, Ph.D.
Gabrielle H. Reem and Herbert J. Kayden Assistant Professor,
Laboratory of Neurophysiology and Behavior,
The Rockefeller University

Neural Circuits for Adaptive Behaviors

Recommended Readings

Caron, S. J., Ruta, V., Abbott, L. F., & Axel, R. (2013). Random convergence of olfactory inputs in the Drosophila mushroom body. Nature, 497(7447), 113-117. doi: 10.1038/nature12063.

Clowney, E. J., Iguchi, S., Bussell, J. J., Scheer, E., & Ruta, V. (2015). Multimodal chemosensory circuits controlling male courtship in Drosophila. Neuron, 87(5), 1036-1049. doi: 10.1016/j.neuron.2015.07.025.

Cohn, R., Morantte, I., & Ruta, V. (2015). Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila. Cell, 163(7), 1742-1755. doi: 10.1016/j.cell.2015.11.019.

Recommended Readings: Li Zhao, Ph.D., March 2

Special Lecture Series
Wednesday, March 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Li Zhao, Ph.D.
Postdoctoral Researcher,
Department of Evolution and Ecology,
University of California Davis

Evolution of Genetic Novelties in Drosophila

Recommended Reading

Li, X., Fan, D., Zhang, W., Liu, G., Zhang, L., Zhao, L., … & Ding, Y. (2015). Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nature Communications, 6(8212). doi:10.1038/ncomms9212

Zhao, L., Saelao, P., Jones, C. D., & Begun, D. J. (2014). Origin and spread of de novo genes in Drosophila melanogaster populations. Science, 343(6172), 769-772. doi: 10.1126/science.1248286.

Zhao, L., Wit, J., Svetec, N., & Begun, D. J. (2015). Parallel gene expression differences between low and high latitude populations of Drosophila melanogaster and D. simulans. PLOS Genetics, 11(5), e1005184. doi: 10.1371/journal.pgen.1005184.

Recommended Readings: Allan C Spradling, Ph.D. May 16

Friday Lecture Series
Friday, May 16, 2014
3:45 p.m., Caspary Auditorium

Allan C Spradling, Ph.D.
Director, Department of Embryology
Carnegie Institution for Science

Investigator, Howard Hughes Medical Institute

Epigenetic and genetic programing of Drosophila development

Recommended Readings:

Empirical Articles

Morris, L. X., & Spradling, A. C. (2011). Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary. Development, 138(11), 2207–2215. doi:10.1242/dev.065508

Nystul, T., & Spradling, A. (2007). An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. Cell Stem Cell, 1(3), 277–285. doi:10.1016/j.stem.2007.07.009

Skora, A. D., & Spradling, A. C. (2010). Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Proceedings of the National Academy of Sciences, 107(16), 7389–7394. doi:10.1073/pnas.1003180107

Xie, T., & Spradling, A. C. (2000). A niche maintaining germ line stem cells in the Drosophila ovary. Science, 290(5490), 328–330. doi:10.1126/science.290.5490.328

Review Papers

Losick, V. P., Morris, L. X., Fox, D. T., & Spradling, A. (2011). Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Developmental Cell, 21(1), 159–171. doi:10.1016/j.devcel.2011.06.018

Morrison, S. J., & Spradling, A. C. (2008). Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell, 132(4), 598–611. doi:10.1016/j.cell.2008.01.038

Recommended Readings: Harmit S. Malik, Ph.D.

Friday Lecture Series

Genetic Conflicts: Beyond the Usual Suspects

Harmit S. Malik, Ph.D., principal investigator, basic sciences division,

Fred Hutchinson Cancer Research Center;

early career scientist, Howard Hughes Medical Institute

December 13, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Malik, H. S. (2009). Evolution of TRIM antiviral genes in primate genomes. Retrovirology, 6(SUPPL. 2)

Malik, H. S., & Bayes, J. J. (2006). Genetic conflicts during meiosis and the evolutionary origins of centromere complexity. Biochemical Society Transactions, 34(4), 569-573

Malik, H. S., & Henikoff, S. (2002). Conflict begets complexity: The evolution of centromeres. Current Opinion in Genetics and Development, 12(6), 711-718

Moran, J. V., & Malik, H. S. (2009). Diamonds and rust: How transposable elements influence mammalian genomes. conference on mobile elements in mammalian genomes. EMBO Reports, 10(12), 1306-1310

Oliver, P. L., Goodstadt, L., Bayes, J. J., Birtle, Z., Roach, K. C., Phadnis, N., . . . Ponting, C. P. (2009). Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genetics, 5(12)

Vermaak, D., & Malik, H. S. (2009). Multiple roles for heterochromatin protein 1 genes in drosophila. Annual Review of Genetic 43 , pp. 467-492


Recommended Readings: S. Lawrence Zipursky, Ph.D.

Friday Lecture Series

Cell Recognition and the Assembly of Neural Circuits

S. Lawrence Zipursky, Ph.D., professor, biological chemistry,

David Geffen School of Medicine, University of California, Los Angeles;

investigator, Howard Hughes Medical Institute

November 15, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Hattori, D., Demir, E., Kim, H. W., Viragh, E., Zipursky, S. L., & Dickson, B. J. (2007). Dscam diversity is essential for neuronal wiring and self-recognition. Nature, 449(7159), 223-227

Hattori, D., Millard, S. S., Wojtowicz, W. M., & Zipursky, S. L. (2008). Dscam-mediated cell recognition regulates neural circuit formation. Annual Review of Cell and Developmental Biology 24 , pp. 597-620

Hummel, T., Vasconcelos, M. L., Clemens, J. C., Fishilevich, Y., Vosshall, L. B., & Zipursky, S. L. (2003). Axonal targeting of olfactory receptor neurons in drosophila is controlled by dscam. Neuron, 37(2), 221-231

Wojtowicz, W. M., Wu, W., Andre, I., Qian, B., Baker, D., & Zipursky, S. L. (2007). A vast repertoire of dscam binding specificities arises from modular interactions of variable ig domains. Cell, 130(6), 1134-1145

Zhu, Y., Nern, A., Zipursky, S. L., & Frye, M. A. (2009). Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly. Current Biology, 19(7), 613-619

Zipursky, S. L., & Sanes, J. R. (2010). Chemoaffinity revisited: Dscams, protocadherins, and neural circuit assembly. Cell, 143(3), 343-353


Recommended Readings: Craig Montell, Ph.D.

Friday Lecture Series

Control of Animal Behavior and Decision Making through TRP Channels

Craig Montell, Ph.D., Duggan Professor,

department of molecular, cellular and developmental biology,

University of California, Santa Barbara

 February 8, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Kwon, Y., Kim, S. H., Ronderos, D. S., Lee, Y., Akitake, B., Woodward, O. M., . . . Montell, C. (2010). Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Current Biology, 20(18), 1672-1678

Lee, Y., Moon, S. J., & Montell, C. (2009). Multiple gustatory receptors required for the caffeine response in drosophila. Proceedings of the National Academy of Sciences of the United States of America, 106(11), 4495-4500

Liu, Z., Wang, X., Yu, Y., Li, X., Wang, T., Jiang, H., . . . Smith, W. W. (2008). A drosophila model for LRRK2-linked parkinsonism. Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2693-2698

Montell, C. (2005). The TRP superfamily of cation channels. Science’s STKE [Electronic Resource] : Signal Transduction Knowledge Environment., 2005(272)

Waldo, G. L., Ricks, T. K., Hicks, S. N., Cheever, M. L., Kawano, T., Tsuboi, K., . . . Kendall Harden, T. (2010). Kinetic scaffolding mediated by a phospholipase C-β and G q signaling complex. Science, 330(6006), 974-980


Recommended Readings: Gerry Rubin, Ph.D.

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

A Molecular Geneticist’s Approach to Understanding the Fly Brain

Gerry Rubin, Ph.D., vice president and executive director,

Howard Hughes Medical Institute Janelia Farm Research Campus

October 19, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Aboobaker, A. A., Tomancak, P., Patel, N., Rubin, G. M., & Lai, E. C. (2005). Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18017-18022

Ashburner, M., Misra, S., Roote, J., Lewis, S. E., Blazej, R., Davis, T., . . . Rubin, G. M. (1999). An exploration of the sequence of a 2.9-mb region of the genome of drosophila melanogaster: The adh region. Genetics, 153(1), 179-219

Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., . . . Spradling, A. C. (2004). The BDGP gene disruption project: Single transposon insertions associated with 40% of drosophila genes. Genetics, 167(2), 761-781

Miklos, G. L. G., & Rubin, G. M. (1996). The role of the genome project in determining gene function: Insights from model organisms. Cell, 86(4), 521-529

Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T. -. B., Misra, S., Murphy, C., . . . Rubin, G. M. (2008). Tools for neuroanatomy and neurogenetics in drosophila. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9715-9720

Pfeiffer, B. D., Ngo, T. -. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010). Refinement of tools for targeted gene expression in drosophila. Genetics, 186(2), 735-755


Recommended Readings: Anne Ephrussi, Ph.D.

Friday Lecture Series

RNP Assembly and Transport in the Drosophila Oocyte

Anne Ephrussi, Ph.D., head, Developmental Biology Unit and head,

International Center for Advanced Training,

European Molecular Biology Laboratory

April 20, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Chekulaeva, M. and A. Ephrussi. 2004. “Drosophila Development: RNA Interference Ab Ovo.” Current Biology 14 (11): R428-R430

Hachet, O. and A. Ephrussi. 2001. “Drosophila Y14 Shuttles to the Posterior of the Oocyte and is Required for Oskar mRNA Transport.” Current Biology 11 (21): 1666-1674

Jambor, H., C. Brunel, and A. Ephrussi. 2011. “Dimerization of Oskar 3′ UTRs Promotes Hitchhiking for RNA Localization in the Drosophila Oocyte.” RNA 17 (12): 2049-2057

Krauss, J., S. López de Quinto, C. Nüsslein-Volhard, and A. Ephrussi. 2009. “Myosin-V Regulates Oskar mRNA Localization in the Drosophila Oocyte.” Current Biology 19 (12): 1058-1063

Vanzo, N., A. Oprins, D. Xanthakis, A. Ephrussi, and C. Rabouille. 2007. “Stimulation of Endocytosis and Actin Dynamics by Oskar Polarizes the Drosophila Oocyte.” Developmental Cell 12 (4): 543-555

Vanzo, N. F. and A. Ephrussi. 2002. “Oskar Anchoring Restricts Pole Plasm Formation to the Posterior of the Drosophila Oocyte.” Development 129 (15): 3705-3714

Recommended Readings: Hugo Bellen, Ph.D., D.V.M.

Friday Lecture Series

Mitochondria and Neurodegeneration

Hugo Bellen, Ph.D., D.V.M., investigator, Howard Hughes Medical Institute;

professor, departments of molecular and human

genetics and neuroscience, director, Program in Developmental Biology,

Baylor College of Medicine

March 30, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:


Han, S. M., H. Tsuda, Y. Yang, J. Vibbert, P. Cottee, S. -J Lee, J. Winek, C. Haueter, H. J. Bellen, and M. A. Miller. 2012. “Secreted VAPB/ALS8 Major Sperm Protein Domains Modulate Mitochondrial Localization and Morphology Via Growth Cone Guidance Receptors.” Developmental Cell 22 (2): 348-362

Pesah, Y., T. Pham, H. Burgess, B. Middlebrooks, P. Verstreken, Y. Zhou, M. Harding, H. Bellen, and G. Mardon. 2004. “Drosophila Parkin Mutants have Decreased Mass and Cell Size and Increased Sensitivity to Oxygen Radical Stress.” Development 131 (9): 2183-2194

Romero, E., G. -H Cha, P. Verstreken, C. V. Ly, R. E. Hughes, H. J. Bellen, and J. Botas. 2008. “Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm.” Neuron 57 (1): 27-40

Venken, K. J. T., Y. He, R. A. Hoskins, and H. J. Bellen. 2006. “P[Acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. Melanogaster.” Science 314 (5806): 1747-1751

Verstreken, P., C. V. Ly, K. J. T. Venken, T. -W Koh, Y. Zhou, and H. J. Bellen. 2005. “Synaptic Mitochondria are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions.” Neuron 47 (3): 365-378