Recommended Readings: Mitzi Kuroda, Ph.D., November 20th

Friday Lecture Series
Friday, November 20, 2015
3:45 p.m., Caspary Auditorium

Mitzi Kuroda, Ph.D.
Professor of Medicine,
Departments of Genetics and Medicine,
Brigham & Women’s Hospital,
Harvard Medical School

Nucleation and Spreading of Chromatin Domains in Epigenetic Models and in Cancer

Recommended Readings

Empirical Articles 

Alekseyenko, A. A., Gorchakov, A. A., Kharchenko, P. V., & Kuroda, M. I. (2014). Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. Proceedings of the National Academy of Sciences, 111(7), 2488-2493. doi: 10.1073/pnas.1400648111

Alekseyenko, A. A., Gorchakov, A. A., Zee, B. M., Fuchs, S. M., Kharchenko, P. V., & Kuroda, M. I. (2014). Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes & Development, 28(13), 1445-1460. doi: 10.1101/gad.241950.114

Alekseyenko, A. A., Walsh, E. M., Wang, X., Grayson, A. R., Hsi, P. T., Kharchenko, P. V., … & French, C. A. (2015). The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes & Development, 29(14), 1507-1523. doi: 10.1101/gad.267583.115

Review Paper

McElroy, K. A., Kang, H., & Kuroda, M. I. (2014). Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila. Open biology, 4(3), 140006. doi: 10.1098/rsob.140006

Recommended Readings: Camilla Sjögren, Ph.D. October 31

Friday Lecture Series
Friday, October 31, 2014
3:45 p.m., Caspary Auditorium

Camilla Sjögren, Ph.D.
Professor, Department of Cell and Molecular Biology
Karolinska Institutet

Connecting chromosome replication and segregation: DNA topology and SMC complexes

Recommended Readings

Empirical Articles

Kegel, A., Betts-Lindroos, H., Kanno, T., Jeppsson, K., Ström, L., Katou, Y., … Sjögren, C. (2011). Chromosome length influences replication-induced topological stress. Nature, 471(7338), 392–6. doi:10.1038/nature09791

Lindroos, H. B., Ström, L., Itoh, T., Katou, Y., Shirahige, K., & Sjögren, C. (2006). Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Molecular Cell, 22(6), 755–67. doi:10.1016/j.molcel.2006.05.014

Review Papers

Carter, S. D., & Sjögren, C. (2012). The SMC complexes, DNA and chromosome topology: right or knot? Critical Reviews in Biochemistry and Molecular Biology, 47(1), 1–16. doi:10.3109/10409238.2011.614593

Jeppsson, K., Kanno, T., Shirahige, K., & Sjögren, C. (2014). The maintenance of chromosome structure: positioning and functioning of SMC complexes. Nature Reviews Molecular Cell Biology, 15(9), 601–614. doi:10.1038/nrm3857