Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight


Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578



Recommended Readings: Ronald M. Evans, Ph.D., December 19

Friday Lecture Series
Friday, December 19, 2014
3:45 p.m, Caspary Auditorium

Ronald M. Evans, Ph.D.,
Professor and Director,
Gene Expression Laboratory,
March of Dimes Chair in Molecular and Developmental Biology,
Salk Institute for Biological Studies
Investigator, Howard Hughes Medical Institute

Nuclear Receptors and Diabesity: a Roadmap to Human Health

Recommended Readings

Empirical Articles

Jonker, J. W., Suh, J. M., Atkins, A. R., Ahmadian, M., Li, P., Whyte, J., … Evans, R. M. (2012). A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature, 485(7398), 391–394. doi:10.1038/nature10998

Suh, J. M., Jonker, J. W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., … Evans, R. M. (2014). Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature, 513(7518), 436–439. doi:10.1038/nature13540

Review Papers

Evans, R. M., & Mangelsdorf, D. J. (2014). Nuclear Receptors, RXR, and the Big Bang. Cell, 157(1), 255–66. doi:10.1016/j.cell.2014.03.012

Hong, S.-H., Ahmadian, M., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2014). Nuclear receptors and metabolism: from feast to famine. Diabetologia, 57(5), 860–867. doi:10.1007/s00125-014-3209-9

Recommended Readings: Edward A. Fisher, M.D., Ph.D., M.P.H.

Friday Lecture Series

The Regression of Atherosclerosis and its Molecular Regulation: Insights from Novel Mouse Models

Genetics of Lipid Disorders and Atherosclerosis: A Symposium in Honor of Jan Breslow’s 70th Birthday

Edward A. Fisher, M.D., Ph.D., M.P.H.,

Leon Charney Professor of CardiovascularMedicine, director, Center for the Prevention of Cardiovascular Disease and director,

Marc and Ruti Bell Program in Vascular Biology,

New York University School of Medicine

 March 15, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Amirbekian, V., Aguinaldo, J. G. S., Amirbekian, S., Hyafil, F., Vucic, E., Sirol, M., . . . Fayad, Z. A. (2009). Atherosclerosis and matrix metalloproteinases: Experimental molecular MR imaging in vivo. Radiology, 251(2), 429-438

Cormode, D. P., Chandrasekar, R., Delshad, A., Briley-Saebo, K. C., Calcagno, C., Barazza, A., . . . Fayad, Z. A. (2009). Comparison of synthetic high density lipoprotein (HDL) contrast agents for MR imaging of atherosclerosis. Bioconjugate Chemistry, 20(5), 937-943

Fayad, Z. A. (2010). Atherosclerotic plaque composition: Analysis with multicolor CT and targeted gold nanoparticles. Radiology, 256(3), 774-782

Feig, J. E., Rong, J. X., Shamir, R., Sanson, M., Vengrenyuk, Y., Liu, J., . . . Fisher, E. A. (2011). HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7166-7171

Parathath, S., Grauer, L., Huang, L. -., Sanson, M., Distel, E., Goldberg, I. J., & Fisher, E. A. (2011). Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes, 60(6), 1759-1769

Van Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., . . . Moore, K. J. (2012). The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nature Immunology, 13(2), 136-143


Recommended Readings: Jeffrey M. Friedman M.D., Ph.D.

Monday Lectures

Leptin and the Homeostratic Control of

Food Intake and Body Weight

Jeffrey M. Friedman M.D., Ph.D.

Howard Hughes Medical Institute

The Rockefeller University

4 p.m.  (refreshments at 3:45)

Monday, December 8, 2008

Welch Hall Level Two

Recommended Review:

Morrison, Christopher D. and Hans-Rudolf Berthoud.  2007.  Neurobiology of nutrition and obesity. Nutrition Reviews.  65(12):517-534.

Related Articles:

Rodenheffer, Matthew S.; Birsoy, Kivanc; and Jeffrey M. Friedman.  2008.   Identification of white adipocyte progenitor cells in vivo.   Cell. 135(2):240-249.


Birsoy, Kivanc; Chen, Zhu; and Jeffrey M. Friedman.  2008.  Transcriptional regulation of adipogenesis by KLF4.  Cell Metabolism.  7(4):339-347.  


Berthoud, Hans-Rudolf.  2007.  Interactions between the “cognitive” and “metabolic” brain in the control of food intake. Physiology & Behavior.  91(5):486-498.


Ruano, G.; J.W.  Goethe, et al.  2007.  Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients.  Molecular Psychiatry.  12(5):474-482.


Berthoud, Hans-Rudolf.  2006. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance.  Obesity.  14(Suppl 5):197-200.    Request article from Markus Library.