Recommended Readings: Dan R. Littman, M.D., Ph.D.

Friday Lecture Series

Shaping of the Systemic Immune Repertoire by the Intestinal Microbiota

Dan R. Littman, M.D., Ph.D., Helen L. and Martin S. Kimmel Professor of Molecular

Immunology; professor of pathology and microbiology, program in molecular pathogenesis,

Skirball Institute of Biomolecular Medicine, New York University Medical Center;

investigator, Howard Hughes Medical Institute

December 20, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Diehl, G. E., Longman, R. S., Zhang, J. -., Breart, B., Galan, C., Cuesta, A., . . . Littman, D. R. (2013). Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX 3 CR1 hi cells. Nature, 494(7435), 116-120

Honda, K., & Littman, D. R. (2012). The microbiome in infectious disease and inflammation. Annual Review of Immunology,  30 , pp. 759-795

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012). Interactions between the microbiota and the immune system. Science, 336(6086), 1268-1273

Kinnebrew, M. A., Buffie, C. G., Diehl, G. E., Zenewicz, L. A., Leiner, I., Hohl, T. M., . . . Pamer, E. G. (2012). Interleukin 23 production by intestinal CD103 +CD11b + dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity, 36(2), 276-287

Littman, D. R., & Pamer, E. G. (2011). Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host and Microbe, 10(4), 311-323

 

Recommended Readings: Michel C. Nussenzweig, M.D., Ph.D.

Friday Lecture Series

Ph.D. Recruitment Lecture

The HIV Vaccine Problem

Michel C. Nussenzweig, M.D., Ph.D., Sherman Fairchild Professor,

senior physician, The Rockefeller University;

investigator, Howard Hughes Medical Institute

 March 8, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings

Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880

Nchinda, G., Kuroiwa, J., Oks, M., Trumpfheller, C., Chae, G. P., Huang, Y., . . . Steinman, R. M. (2008). The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. Journal of Clinical Investigation, 118(4), 1427-1436

Scheid, J. F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T. Y. K., . . . Nussenzweig, M. C. (2011). Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science, 333(6049), 1633-1637

Trumpfheller, C., Finke, J. S., López, C. B., Moran, T. M., Moltedo, B., Soares, H., . . . Steinman, R. M. (2006). Intensified and protective CD4 + T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. Journal of Experimental Medicine, 203(3), 607-617

Zhou, T., Georgiev, I., Wu, X., Yang, Z. -., Dai, K., Finzi, A., . . . Kwong, P. D. (2010). Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science, 329(5993), 811-817

Recommended Readings: Sarah Schlesinger M.D. March 7, 2011

Monday Lecture Series

Vaccines that Target Dendritic Cells

Sarah Schlesinger  M.D.

Senior Attending Physician and Associate Professor of Clinical Investigation

 Cellular Physiology and Immunology

March 7, 2011

4:00 p.m.-5:00 p.m. Caspary Auditorium

Recommended Readings

Dhodapkar MV; Sznol M; Wang D, et al.  2010.  Early development of CDX-1401, a novel vaccine targeting NY-ESO-1 to the dendritic cel receptor DEC-205.  Journal of Immunotherapy.  33(8):895-896   Request Article from Markus Library. 

Wanialla CN; Faul EJ; Gomme EA, et al.  2010.  Dendritic cells infected by recombinant rabies virus vaccine vector expressing HIV-1 Gag are immunogenic even in the presence of vector-specific  immunityVaccine.  29(1):130-140

Fiorentini S; Giagulli C; Caccuri F, et al.  2010.  HIV-1 matrix protein p17: a candidate antigen for therapeutic vaccines against AIDS.   Pharmacology & Therapeutics.  128(3):433-444  Request Article from Markus Library.

De Groot A; Buhlmann J; Weber C, et al.  2010.  De-Tolerization of anti-DEC-205 for HIV vaccine delivery.  (abstract only)  AIDS Research and Human Retroviruses.   26(10):A135-A136

Ahlers, JD; and  IM Belyakov.  2009.  Strategies for optimizing targeting and delivery of mucosal HIV vaccinesEuropean Journal of Immunology.  39(10):2657-2669

Kloverpris HN; Karlsson I; Thorn M, et al.  2009.   Immune hierarchy among HIV-1 CD8+T cell epitopes delivered by dendritic cells depends on MHC-I binding irrespective of mode of loading and immunization of HLA-A*0201 mice.  APMIS  117(11):8489-855

Demberg T; and M. Robert-Guroff.  2009.  Mucosal immunity and protection against HIV-SIV infection: strategies and challenges for vaccine design.  International Reviews of Immunology.  28(1-2):20-28   Please request from Markus Library.

Gruber A; Chalmers AS; Rasmussem RA, et al.  2007.  Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.   Viral Immunology.  20(1):160-169.