Recommended Readings: Zhijian ‘James’ Chen, Ph.D. September 26

Friday Lecture Series
Friday, September 26, 2014
3:45 p.m., Caspary Auditorium

Zhijian “James” Chen, Ph.D.
George L. MacGregor Distinguished Chair in Biomedical Sciences,
Director, Center for Inflammation,
Research Professor, Department of Molecular Biology,

The University of Texas Southwestern Medical Center
Investigator, Howard Hughes Medical Institute

Enemy Within – Immune and Autoimmune Responses to cytosolic DNA and RNA

Recommended Readings

Empirical Articles

Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., … Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science, 341(6148), 903–906. doi:10.1126/science.1240933

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science, 341(6152), 1390–1394. doi:10.1126/science.1244040

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science, 339(6121), 786–791. doi:10.1126/science.1232458

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., … Chen, Z. J. (2010). Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell, 141(2), 315–330. doi:10.1016/j.cell.2010.03.029

Review Papers

Cai, X., Chiu, Y.-H., & Chen, Z. J. (2014). The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Molecular Cell, 54(2), 289–296. doi:10.1016/j.molcel.2014.03.040

Wu, J., & Chen, Z. J. (2014). Innate immune sensing and signaling of cytosolic nucleic acids. Annual Review of Immunology, 32, 461–88. doi:10.1146/annurev-immunol-032713-120156

Recommended Readings: Hugo Bellen, Ph.D., D.V.M.

Friday Lecture Series

Mitochondria and Neurodegeneration

Hugo Bellen, Ph.D., D.V.M., investigator, Howard Hughes Medical Institute;

professor, departments of molecular and human

genetics and neuroscience, director, Program in Developmental Biology,

Baylor College of Medicine

March 30, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:


Han, S. M., H. Tsuda, Y. Yang, J. Vibbert, P. Cottee, S. -J Lee, J. Winek, C. Haueter, H. J. Bellen, and M. A. Miller. 2012. “Secreted VAPB/ALS8 Major Sperm Protein Domains Modulate Mitochondrial Localization and Morphology Via Growth Cone Guidance Receptors.” Developmental Cell 22 (2): 348-362

Pesah, Y., T. Pham, H. Burgess, B. Middlebrooks, P. Verstreken, Y. Zhou, M. Harding, H. Bellen, and G. Mardon. 2004. “Drosophila Parkin Mutants have Decreased Mass and Cell Size and Increased Sensitivity to Oxygen Radical Stress.” Development 131 (9): 2183-2194

Romero, E., G. -H Cha, P. Verstreken, C. V. Ly, R. E. Hughes, H. J. Bellen, and J. Botas. 2008. “Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm.” Neuron 57 (1): 27-40

Venken, K. J. T., Y. He, R. A. Hoskins, and H. J. Bellen. 2006. “P[Acman]: A BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. Melanogaster.” Science 314 (5806): 1747-1751

Verstreken, P., C. V. Ly, K. J. T. Venken, T. -W Koh, Y. Zhou, and H. J. Bellen. 2005. “Synaptic Mitochondria are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions.” Neuron 47 (3): 365-378

Recommended Readings: Anthony Leung Ph.D. April 12, 2010

Monday Lecture Series

Poly(ADP-ribose) Regulates microRNA Activity and

Stress Responses in the Cytoplasm

Anthony Leung, Ph.D.,

Senior Postdoctoral Fellow

Koch Institute for Integrative Cancer Research

Massachusetts Institute of Technology

Special Fellow of Leukemia and Lymphoma Society 

April 12, 2010

Welch Hall,  Level Two

4:00 p.m.-5:00 p.m

Recommended Readings:

Pothof J, Verkaik NS, Hoeijmakers JHJ, et al.  2009.    MicroRNA responses and stress granule formation modulate the DNA damage response.  CELL CYCLE    8(21):3462-3468   

Pothof J, Verkaik NS, van IJcken W, et al.   2009.   MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.   EMBO JOURNAL   28(14):2090-2099

Andersson MK, Stahlberg A, Arvidsson Y, et al.  2008.   The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.   BMC CELL BIOLOGY   9(Article No. 37)

 Leung AKL.  2008.   MicroRNA and stress: Cellular and molecular perspectives.    BIOLOGICAL PSYCHIATRY    63(7): 52S-53S   Supplement: Suppl. S   

Leung AKL, Calabrese JM, Sharp PA.  2006.   Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA    103(48):18125-18130   

Balzer E, Moss EG.  2007.  Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.     RNA BIOLOGY    4(1):16-25