Recommended Readings: Jue Chen, Ph.D., Monday December 10, 2018

Monday Lectures

Monday, December 10, 2018  4:00 p.m.

Carson Family Auditorium

Jue Chen, Ph.D.

William E. Ford Professor and Head

Laboratory of Membrane Biology and Biophysics

The Rockefeller University

CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis


Recommended Readings:

Empirical Articles

Kim, Youngjin; Chen, Jue. (2018). Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. SCIENCE. 359 (6378): 915-919

Zhang, Zhe; Liu, Fangyu; Chen, Jue. (2017). Conformational Changes of CFTR upon Phosphorylation and ATP Binding. CELL. 170 (3): 483-+

Liu, Fangyu; Zhang, Zhe; Csanady, Laszlo; et al. (2017). Molecular Structure of the Human CFTR Ion Channel. CELL. 169 (1): 85-+

Zhang, Zhe; Chen, Jue. (2016). Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator. CELL. 167 (6): 1586-+

Oldham, Michael L.; Davidson, Amy L.; Chen, Jue. (2008). Structural insights into ABC transporter mechanism. CURRENT OPINION IN STRUCTURAL BIOLOGY. 18 (6): 726-733

Review Paper

Davidson, Amy L.; Dassa, Elie; Orelle, Cedric; et al. (2008). Structure, function, and evolution of bacterial ATP-binding cassette systems. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. 72 (2): 317-364


Recommended Readings: David C. Gadsby, Ph.D., November 30th

Monday Lecture Series
Monday, November 30, 2015
4:00 p.m., Carson Family Auditorium (CRC)

David C. Gadsby, Ph.D.
Patrick A. Gerschel Family Professor and Head
Laboratory of Cardiac and Membrane Physiology,
The Rockefeller University

Motions that gate single CFTR channels, the ABC proteins whose failure causes cystic fibrosis

Recommended Readings

Chaves, L. A. P., & Gadsby, D. C. (2015). Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. The Journal of General Physiology, 145(4), 261-283. doi:10.1085/jgp.201411347

Csanády, L., Vergani, P., & Gadsby, D. C. (2010). Strict coupling between CFTR’s catalytic cycle and gating of its Cl− ion pore revealed by distributions of open channel burst durations. Proceedings of the National Academy of Sciences, 107(3), 1241-1246. doi:10.1073/pnas.0911061107

Gadsby, D. C., Vergani, P., & Csanády, L. (2006). The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature, 440(7083), 477-483. doi:10.1038/nature04712

Vergani, P., Lockless, S. W., Nairn, A. C., & Gadsby, D. C. (2005). CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature, 433(7028), 876-880. doi:10.1038/nature03313