Recommended Readings: Robert McGinty, M.D., Ph.D., February 18th

Special Lecture,
Wednesday, February 18th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Robert McGinty, M.D., Ph.D.
Damon Runyun Postdoctoral Fellow,
Dale F. Frey Breakthrough Scientist,
Department of Biochemistry & Molecular Biology,
The Pennsylvania State University

Chemistry, Crystallography and Nucleosome Ubiquitylation

Recommended Readings

Empirical Articles

Kim, J., Kim, J., McGinty, R. K., Nguyen, U. T., Muir, T. W., Allis, C. D., & Roeder, R. G. (2013). The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell, 49(6), 1121-1133. doi:10.1016/j.molcel.2013.01.034

McGinty, R. K., Henrici, R. C., & Tan, S. (2014). Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514(7524), 591-596. doi:10.1038/nature13890

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T., Kim, J., Sun, X. J., … & Roeder, R. G. (2013). SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2), 297-310. doi:10.1016/j.cell.2013.06.027

Review Papers

McGinty, R. K., & Tan, S. (In Press). Nucleosome structure and function. Chemical Reviews. doi:10.1021/cr500373h

Recommended Readings: Kazuhiro Yamada, PhD October 1, 2012

Crystallographic Studies of Large Complexes: From the Yeast Chromatin

Remodeling Factor ISW1a to the Entire Nucleosome-Traversing

Transcription Machinery

Kazuhiro Yamada,  PhD

Senior Scientist/Over-assistant

Institute of Molecular Biology and Biophysics

ETH Zurich

Monday, October 1, 2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

 Recommended Readings:

Yen, K.; Vinayachandran, V.; Batta, K.; et al.   2012. Genome-wide Nucleosome Specificity and Directionality of Chromatin Remodelers.  CELL   149(7):1461-1473   DOI: 10.1016/j.cell.2012.04.036

Richmond, Timothy J.  2012. Nucleosome recognition and spacing by chromatin remodelling factor ISW1a.   BIOCHEMICAL SOCIETY TRANSACTIONS,  40: 347-350  DOI: 10.1042/BST20110748   Please request from Markus Library.

De Cian, A; Praly, E; Ding, F; et al.  2012.  ATP-Independent Cooperative Binding of Yeast Isw1a to Bare and Nucleosomal DNA.    PLOS ONE   7(2): e31845   DOI: 10.1371/journal.pone.0031845

Sharma, A.; Jenkins, K. R.; Heroux, A.; et al.  2011. Crystal Structure of the Chromodomain Helicase DNA-binding Protein 1 (Chd1) DNA-binding Domain in Complex with DNA.  JOURNAL OF BIOLOGICAL CHEMISTRY    286(49):42099-42104   DOI: 10.1074/jbc.C111.294462

Yamada, K.; Frouws, T. D.; Angst, B.; et al. 2011.  Structure and mechanism of the chromatin remodelling factor ISW1a.   NATURE.  472(7344):U448-U536   DOI: 10.1038/nature09947

Pinskaya, M.; Nair, A.; Clynes, D.; et al.  2009.  Nucleosome Remodeling and Transcriptional Repression Are Distinct Functions of Isw1 in Saccharomyces cerevisiae.  MOLECULAR AND CELLULAR BIOLOGY   29(9): 2419-2430   DOI: 10.1128/MCB.01050-08