Recommended Readings: Jennifer Doudna, Ph.D. September 19

Friday Lecture Series
Friday, September 19, 2014
3:45 p.m., Caspary Auditorium

Jennifer Doudna, Ph.D.
Li Ka Shing Chancellor’s Chair in Biomedical and Health Sciences,
Professor of Biochemistry, Biophysics and Structural Biology,
Departments of Molecular and Cell Biology and Chemistry,
University of California, Berkeley
Investigator, Howard Hughes Medical Institute

CRISPR Systems: A Revolution in Basic Science and Biotechnology

Recommended Readings

Empirical Articles

Haurwitz, R. E., Jinek, M., Wiedenheft, B., Zhou, K., & Doudna, J. a. (2010). Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science, 329(5997), 1355–1358. doi:10.1126/science.1192272

Sternberg, S. H., Redding, S., Jinek, M., Greene, E. C., & Doudna, J. a. (2014). DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature, 507(7490), 62–67. doi:10.1038/nature13011

Wiedenheft, B., Sternberg, S. H., & Doudna, J. a. (2012). RNA-guided genetic silencing systems in bacteria and archaea. Nature, 482(7385), 331–338. doi:10.1038/nature10886

Review Papers

Bhaya, D., Davison, M., & Barrangou, R. (2011). CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. Annual Review of Genetics, 45, 273–97. doi:10.1146/annurev-genet-110410-132430

Hsu, P. D., Lander, E. S., & Zhang, F. (2014). Development and Applications of CRISPR-Cas9 for Genome Engineering. Cell, 157(6), 1262–1278. doi:10.1016/j.cell.2014.05.010

Recommended Readings: Luciano Marraffini, Ph.D. Jan 11, 2010

Monday Lecture Series

Self vs Non-self Discrimination During CRISPR Immunity

Against Horizontal Gene Transfer

Luciano Marraffini, Ph.D.,

Post Doctoral Fellow, Department of Biochemistry, Molecular Biology and Cell Biology

Northwestern University

January 11, 2010

4:00p.m.-5:00 p.m.

Welch Hall, Level Two

Recommended readings:

Van der Oost, J; Jore, MM; Westra, ER; et al.  2009.  CRISPR-based adaptive and heritable immunity in prokaryotesTrends in biochemical sciences  34(8):401-407

Agari, Y; Yokoyama, S; Kuramitse, S; Shinkai, A.  2008.  X-ray crystal stryctyre of a CRISPR-associated protein, CSe2, from Thermus themaphilus, HB8.  Proteins – Structure Function and bioinformatics  73(4):1063-1067

Horvath, P; Romero, DA; Coute-Monvoison, AC; Richards, M; et al.  2008.  Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus.  Journal of bacteriology  1990(4):1401-1412

Brouns, SJJ; Jore,MM; Lundgren, M; Westra R; et al.  2008   Small CRISPR RNAs guide antiviral defense in prokaryotes.   SCIENCE  321(5891): 960-964 

Barrangou, RF; Fremaux, C; Deveau, H; Richards, M; Boyaval, P; Moineau, S; RFomero, DA; Horvath, P.  2007.  CRISPR provides acquired resistance against viruses in prokaryotes.  SCIENCE  315(5819):1709-1712

Tesch, LD; Raghavendra, MP; Bedsted-Faarvang, T; et al.  2005.  Specificity and reactive loop length requirements for cmA inhibition of serine proteases.  Protein science  14(2):533-542

Beloglazona, N; Brown, G; Zimmerman, MD; Proudfoot, M; Marakova, KS; et al.  2008.  A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.  Journal of biological chemistry.  283(29): 20361-20371