In the November 11, 2008 issue of Developmental Cell, investigators from the University of Utah School of Medicine report the results of their studies in an article entitled Wnt/B-Catenin and Fgf Signaling Control Collective Cell Migration by Restricting Chemokine Receptor Expression. These studies demonstrate a link between Wnt and Fgf signaling pathways in zebrafish and their impact on collective cell migration.
The Wnt pathway regulates cell-to-cell communication in embryogenesis and cancer and Fgf influences embryongenesis, healing, and cell proliferation. Piotrowski and Aman demonstrate for the first time that the interaction between Wnt and Fgf pathways is critical for collective cell migration. Each pathway can restrict chemokine receptor expression and thereby elucidate how some types of cancer metastisize.