Recommended Readings: Michael W. Young, Ph.D., April 20

Monday Lecture Series
Monday, April 20, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Michael W. Young, Ph.D.
Vice President for Academic Affairs,
Richard and Jeanne Fisher Professor and Head,
Laboratory of Genetics,
The Rockefeller University

Genes that Regulate Sleep and Circadian Rhythms

Recommended Readings

Empirical Articles

Levy, C., Zoltowski, B. D., Jones, A. R., Vaidya, A. T., Top, D., Widom, J., … & Leys, D. (2013). Updated structure of Drosophila cryptochrome. Nature, 495(7441), E3-E4. doi:10.1038/nature11995.

Rogulja, D., & Young, M. W. (2012). Control of sleep by cyclin A and its regulator. Science, 335(6076), 1617-1621. doi:10.1126/science.1212476.

Stavropoulos, N., & Young, M. W. (2011). insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron, 72(6), 964-976. doi:10.1016/j.neuron.2011.12.003.

Zoltowski, B. D., Vaidya, A. T., Top, D., Widom, J., Young, M. W., & Crane, B. R. (2011). Structure of full-length Drosophila cryptochrome. Nature, 480(7377), 396-399. doi:10.1038/nature10618.

Review Papers

Boothroyd, C. E., & Young, M. W. (2008). The in (put)s and out (put)s of the Drosophila circadian clock. Annals of the New York Academy of Sciences, 1129(1), 350-357. doi:10.1196/annals.1417.006

Crane, B. R., & Young, M. W. (2014). Interactive features of proteins composing eukaryotic circadian clocks. Annual Review of Biochemistry, 83, 191-219. doi:10.1146/annurev-biochem-060713-035644

Recommended Readings: Lora Hooper, Ph.D. April 2

Wednesday, April 2, 2014
4:00 p.m., Carson Family Auditorium

Lora Hooper, Ph.D.
University of Texas Southwestern Medical Center
Investigator, HHMI

Circadian Regulation of Intestinal Immunity

Recommended Readings:

Empirical Articles

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V, Koh, G. Y., Nagy, A., … Gordon, J. I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences, 101(44), 15718–15723. doi:10.1073/pnas.0407076101

Cash, H. L., Whitham, C. V, Behrendt, C. L., & Hooper, L. V. (2006). Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science, 313(5790), 1126–1130. doi:10.1126/science.1127119

Scheer, F. a J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proceedings of the National Academy of Sciences, 106(11), 4453–4458. doi:10.1073/pnas.0808180106

Yu, X., Rollins, D., Ruhn, K. a, Stubblefield, J. J., Green, C. B., Kashiwada, M., … Hooper, L. V. (2013). TH17 cell differentiation is regulated by the circadian clock. Science, 342(6159), 727–730. doi:10.1126/science.1243884

Review Papers

Arjona, A., Silver, A. C., Walker, W. E., & Fikrig, E. (2012). Immunity’s fourth dimension: approaching the circadian-immune connection. Trends in Immunology, 33(12), 607–612. doi:10.1016/

Hooper, L. V, & Macpherson, A. J. (2010). Immune adaptations that maintain homeostasis with the intestinal microbiota. Nature Reviews Immunology, 10(3), 159–169. doi:10.1038/nri2710

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009). IL-17 and Th17 cells. Annual Review of Immunology, 27, 485–517. doi:10.1146/annurev.immunol.021908.132710

Recommended Readings: Ueli Schibler Ph.D. February 14

Friday Lecture Series
Friday, February 14, 2014
3:45 p.m., Caspary Auditorium

Ueli Schibler, PhD
University of Geneva
Department of Molecular Biology

The Mammalian Circadian Timing System: Communication Between Clocks

Recommended Readings:

Empirical Articles

Balsalobre, A., Brown, S.A., Marcacci, L., … Schibler, U. (2000). Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science, 289(5488), 2344–2347. doi:10.1126/science.289.5488.2344

Balsalobre, A., Damiola, F., & Schibler, U. (1998). A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell, 93(6), 929–937. doi:10.1016/S0092-8674(00)81199-X

Damiola, F., Le Minh, N., Preitner, N., … Schibler, U. (2000). Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development, 14(23), 2950–2961. doi:10.1101/gad.183500

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013). Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell, 152(3), 492–503. doi:10.1016/j.cell.2012.12.027

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007). System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biology, 5(2), e34. doi:10.1371/journal.pbio.0050034

Review Papers

Dibner, C., Schibler, U., & Albrecht, U. (2010). The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annual Review of Physiology, 72, 517–549. doi:10.1146/annurev-physiol-021909-135821

Gachon, F., Nagoshi, E., Brown, S. a, Ripperger, J., & Schibler, U. (2004). The mammalian circadian timing system: from gene expression to physiology. Chromosoma, 113(3), 103–112. doi:10.1007/s00412-004-0296-2

Schibler, U., & Sassone-Corsi, P. (2002). A web of circadian pacemakers. Cell, 111(7), 919–922. doi:10.1016/S0092-8674(02)01225-4

Recommended Readings: Kristin Tessmar-Raible Ph.D. February 3

Monday, February 3, 2014
4:00 p.m., Carson Family Auditorium

Kristin Tessmar-Raible, Ph.D.
Junior Group Leader
Max F. Perutz Laboratories
University of Vienna

The Impact of Light on Nervous System Function

Recommended Readings:

Empirical Papers

Backfisch, B., Veedin Rajan, V. B., Fischer, R. M., Lohs, C., Arboleda, E., Tessmar-Raible, K., & Raible, F. (2013). Stable transgenesis in the marine annelid Platynereis dumerilii sheds new light on photoreceptor evolution. Proceedings of the National Academy of Sciences of the United States of America, 110(1), 193–198. doi:10.1073/pnas.1209657109

Fischer, R. M., Fontinha, B. M., Kirchmaier, S., Steger, J., Bloch, S., Inoue, D., … Tessmar-Raible, K. (2013). Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain. PLoS Biology, 11(6), e1001585. doi:10.1371/journal.pbio.1001585

Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., … Tessmar-Raible, K. (2013). Circadian and circalunar clock interactions in a marine annelid. Cell Reports, 5(1), 99–113. doi:10.1016/j.celrep.2013.08.031

Review Articles

Roenneberg, T., & Merrow, M. (2005). Circadian clocks – the fall and rise of physiology. Nature Reviews Molecular Cell Biology, 6(12), 965–971. doi:10.1038/nrm1766

Tessmar-Raible, K., Raible, F., & Arboleda, E. (2011). Another place, another timer: Marine species and the rhythms of life. BioEssays, 33(3), 165–172. doi:10.1002/bies.201000096

Recommended Readings: Arun Mehra, Ph.D.; September 9, 2009

Monday Lecture Series

Temperature Compensation in Fungal and Bacterial Oscillators

Arun Mehra, Ph.D.

Postdoctoral Fellow, Department of Genetics,

Dartmouth Medical School

Wednesday, September 9, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Dunlap, J. C., J. J. Loros, H. V. Colot, A. Mehra, W. J. Belden, M. Shi, C. I. Hong, et al. 2007. A circadian clock in Neurospora: How genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day. Cold Spring Harbor symposia on quantitative biology. 72:57-68.

Gooch, V. D., A. Mehra, L. F. Larrondo, J. Fox, M. Touroutoutoudis, J. J. Loros, and J. C. Dunlap. 2008. Fully codon-optimized luciferase uncovers novel temperature characteristics of the Neurospora clock. Eukaryotic Cell. 7(1):28-37.

Loros, J. J., J. C. Dunlap, L. F. Larrondo, M. Shi, W. J. Belden, V. D. Gooch, C. H. Chen, et al. 2007. Circadian output, input, and intracellular oscillators: Insights into the circadian systems of single cells. Cold Spring Harbor symposia on quantitative biology. 72:201-214. Contact Markus Library by sending article request to or fax request to ext. 7840.

Mehra, A., C. I. Hong, M. Shi, J. J. Loros, J. C. Dunlap, and P. Ruoff. 2006. Circadian rhythmicity by autocatalysis. PLoS Computational Biology. 2(7):0816-0823.

Mehra, A., Hong, C.I., Shi, M., Loros, J.J., Dunlap, J.C., Ruoff, P. 2006. Circadian rhythmicity by autocatalysis. PLoS computational biology. 2(7).

Mehra, A., M. Shi, C. L. Baker, H. V. Colot, J. J. Loros, and J. C. Dunlap. 2009. A role for casein kinase 2 in the mechanism underlying circadian temperature compensation. Cell. 137(4):749-760.