Recommended Readings: Jue Chen, Ph.D., Monday December 10, 2018

Monday Lectures

Monday, December 10, 2018  4:00 p.m.

Carson Family Auditorium

Jue Chen, Ph.D.

William E. Ford Professor and Head

Laboratory of Membrane Biology and Biophysics

The Rockefeller University

CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis


Recommended Readings:

Empirical Articles

Kim, Youngjin; Chen, Jue. (2018). Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. SCIENCE. 359 (6378): 915-919

Zhang, Zhe; Liu, Fangyu; Chen, Jue. (2017). Conformational Changes of CFTR upon Phosphorylation and ATP Binding. CELL. 170 (3): 483-+

Liu, Fangyu; Zhang, Zhe; Csanady, Laszlo; et al. (2017). Molecular Structure of the Human CFTR Ion Channel. CELL. 169 (1): 85-+

Zhang, Zhe; Chen, Jue. (2016). Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator. CELL. 167 (6): 1586-+

Oldham, Michael L.; Davidson, Amy L.; Chen, Jue. (2008). Structural insights into ABC transporter mechanism. CURRENT OPINION IN STRUCTURAL BIOLOGY. 18 (6): 726-733

Review Paper

Davidson, Amy L.; Dassa, Elie; Orelle, Cedric; et al. (2008). Structure, function, and evolution of bacterial ATP-binding cassette systems. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. 72 (2): 317-364


Recommended Readings: David C. Gadsby, PhD April 4, 2011

Monday Lecture Series

How CFTR, the Model ABC Protein Defective in Cystic Fibrosis, Works

 Davd C. Gadsby PhD

 Patrick A. Gerschel Family Professor

 Laboratory of Cardiac and Membrane Physiology



Recommended Readings

Wang, G. Y.  2011.  The inhibition mechanism of non-phosphorylated Ser(768) in the regulatory domain of cystic fibrosis trasnmembrane conductance regulatorJournal of Biological Chemistry.  286(3):2171-2181.

Koepikin, Z.; Sohma, Y.; Li, M.; et al.  2010.  On the mechanism of CFTR inhidition by a thiasolidinone derivativeJournal of General Physiology.  136(6):659-671.

El Hiani, Y. and  Linsdell, P.   2010.  Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.  Journal of Biological Chemistry.  285(42):32126-32140. 

Szollosi, A.; Vergani. P. and Csanady, L.   2010.  Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response tp ATP binding at NBD2 Journal of General Physiology.  136(4):407-423.

Bai, Y. H.; Li, M. and Hawang, T.C.  2010.  Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.   Journal of General Physiology.  136(3):293-309.

Gadsby, D. C.; Vergani, P.; Mense, M.; et al.  2010.  Control of CFTR’s gates by ATP binding and hydrolysis.  Pediatric Pulmonology.   Supple.  33: 114-115.    Please request from Markus Library.

Csanady, L.; Vergani, P. and Gadsby, D. C.  2010.  Strict coupling between CFTR’s catalytic cycle and gating of its CL-ion pore revealed by distributions of open channel burst durations.   PNAS.  107(3):1241-1246.

Muallem, D. and Vergani, P.  2009.  ATP hydroloysis-driven gating in cystic fibrosis trasnmembrance conductance regulator.  Philosophical Transactions of the Royal Society B-Biological Sciences.  364(1514):247-255. doi: 10.1098/rstb.2008.0191.

Aleksandrov, A. A.; Aleksandrov, L.A. and Riordan, J.R.  2007.   CFTR (ABCC7) is a hydrolysable-ligand-gated channel Pflugers Archive-European Journal of Physiology.  453(5):693-702