Recommended Readings: Sheetz, M., Kenan, W., Spudich, J., and Vale, R.

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Biological Motility and Mechanotransduction

Michael Sheetz, Ph.D., William R. Kenan Jr. Professor,Columbia University, 

Myosin Pulling and Mechanotransduction

James Spudich, Ph.D., professor of biochemistry, Stanford School of Medicine, Hypertrophic and Dilated Cardiomyopathies:

Single Molecule Analysis of Human Cardiac Myosin

Ronald Vale, Ph.D., professor, University of California, San Francisco; investigator, Howard Hughes Medical Institute (HHMI),

Structure and Mechanism of the Dynein Motor Protein

April 6, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Carter, A. P., C. Cho, L. Jin, and R. D. Vale. 2011. “Crystal Structure of the Dynein Motor Domain.” Science 331 (6021): 1159-1165

Chuan, P., J. A. Spudich, and A. R. Dunn. 2011. “Robust Mechanosensing and Tension Generation by Myosin VI.” Journal of Molecular Biology 405 (1): 105-112

Hartman, M. A., D. Finan, S. Sivaramakrishnan, and J. A. Spudich. 2011. Principles of Unconventional Myosin Function and Targeting. Annual Review of Cell and Developmental Biology. Vol. 27: 133-155

Kardon, J. R. and R. D. Vale. 2009. “Regulators of the Cytoplasmic Dynein Motor.” Nature Reviews Molecular Cell Biology 10 (12): 854-865

Vogel, V. and M. Sheetz. 2006. “Local Force and Geometry Sensing Regulate Cell Functions.” Nature Reviews Molecular Cell Biology 7 (4): 265-275

Vogel, V. and M. P. Sheetz. 2009. “Cell Fate Regulation by Coupling Mechanical Cycles to Biochemical Signaling Pathways.” Current Opinion in Cell Biology 21 (1): 38-46

Recommended Readings: Bonnie Bassler, Ph.D.; April 3, 2009

Friday Lecture Series

“Eavesdropping on Bacterial Conversations”

Wiley Prize in Biomedical Sciences

Bonnie Bassler, Ph.D.

Squibb Professor, Department of Molecular Biology, Princeton University and Investigator, Howard Hughes Medical Institute

April 3, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Hammer, B. K., and B. L. Bassler. 2009. Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. Journal of Bacteriology. 91(1): 169-177.


Hammer, B.K., Bassler, B.L. 2007. Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proceedings of the National Academy of Sciences of the United States of America. 104(27): 11145-11149.


Higgins, D. A., M. E. Pomianek, C. M. Kraml, R. K. Taylor, M. F. Semmelhack, and B. L. Bassler. 2007. The major Vibrio cholerae autoinducer and its role in virulence factor production. Nature. 450 (7171): 883-886.


Neiditch, M. B., M. J. Federle, A. J. Pompeani, R. C. Kelly, D. L. Swem, P. D. Jeffrey, B. L. Bassler, and F. M. Hughson. 2006. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell. 126 (6): 1095-1108.


Svenningsen, S. L., K. C. Tu, and B. L. Bassler. 2009. Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing. EMBO Journal. 28 (4): 429-439.


Waters, C. M., and B. L. Bassler. 2006. The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers. Genes and Development. 20(19): 2754-2767.


Waters, C. M., W. Lu, J. D. Rabinowitz, and B. L. Bassler. 2008. Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. Journal of Bacteriology. 190(7): 2527-2536.