Recommended Readings: Angelika Amon, Ph.D., May 27

Friday Lecture Series
Friday, May 27, 2016
3:45 p.m., Caspary Auditorium

Angelika Amon, Ph.D.
Kathleen and Curtis Marble Professor of Cancer Research,
Koch Institute for Integrative Cancer Research,
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

The Causes and Consequences of Aneuploidy

Recommended Readings:

Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., … & Amon, A. (2011). Aneuploidy drives genomic instability in yeast. Science, 333(6045), 1026-1030. doi: 10.1126/science.1206412.

Sheltzer, J. M., Torres, E. M., Dunham, M. J., & Amon, A. (2012). Transcriptional consequences of aneuploidy. Proceedings of the National Academy of Sciences, 109(31), 12644-12649. doi: 10.1073/pnas.1209227109.

Tang, Y. C., & Amon, A. (2013). Gene copy-number alterations: a cost-benefit analysis. Cell, 152(3), 394-405. doi: 10.1016/j.cell.2012.11.043.

Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007). Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science, 317(5840), 916-924. doi: 10.1126/science.1142210

Recommended Readings: Gregory Alushin, Ph.D., February 24

Special Lecture Series
Wednesday, February 24, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Gregory Alushin, Ph.D.
Early Independent Scientist,
National Heart Lung and Blood Institute

Cytoskeletal Structural Plasticity in Force Generation and Mechanosensation

Recommended Reading

Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014). High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis. Cell, 157(5), 1117-1129. doi: 10.1016/j.cell.2014.03.053.

Kim, L. Y., Thompson, P. M., Lee, H. T., Pershad, M., Campbell, S. L., & Alushin, G. M. (2015). The structural basis of actin organization by vinculin and metavinculin. Journal of Molecular Biology. doi: 10.1016/j.jmb.2015.09.031.

Zhang, R., Alushin, G. M., Brown, A., & Nogales, E. (2015). Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins. Cell, 162(4), 849-859. doi: 10.1016/j.cell.2015.07.012.

Recommended Readings: Elaine Fuchs, Ph.D. November 3

Monday Lecture Series
Monday, November 3, 2014
4:00 p.m., Carson Family Auditorium

Elaine Fuchs, Ph.D.
Rebecca C. Lancefield Professor and Head,
Laboratory of Mammalian Cell Biology and Development,
The Rockefeller University
Investigator,
Howard Hughes Medical Institute

Stem Cells in Silence, Action and Cancer

Recommended Readings

Empirical Articles

Blanpain, C., Lowry, W., & Geoghegan, A. (2004). Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell, 118(5), 635–648. doi:10.1016/j.cell.2004.08.012

Lechler, T., & Fuchs, E. (2005). Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature, 437(7056), 275–280. doi:10.1038/nature03922

Yi, R., Poy, M. N., Stoffel, M., & Fuchs, E. (2008). A skin microRNA promotes differentiation by repressing “stemness”. Nature, 452(7184), 225–9. doi:10.1038/nature06642

Review Papers

Fuchs, E., Tumbar, T., & Guasch, G. (2004). Socializing with the neighbors: stem cells and their niche. Cell, 116(6), 769–778. doi:10.1016/S0092-8674(04)00255-7

Hsu, Y.-C., Li, L., & Fuchs, E. (2014). Emerging interactions between skin stem cells and their niches. Nature Medicine, 20(8), 847–856. doi:10.1038/nm.3643