Recommended Readings: Beth Levine, M.D., September 25th

Friday Lecture Series
Friday, September, 25th 2015
3:45 p.m., Caspary Auditorium

Beth Levine, M.D.
Charles Cameron Sprague Distinguished Chair in Biomedical Science,
Director, Center for Autophagy Research,
Professor, Department of Internal Medicine and Microbiology,
University of Texas Southwestern Medical Center
Investigator, Howard Hughes Medical Institute

Molecular Regulation and Functions of Beclin 1 and the Autophagy Pathway

Recommended Readings

Empirical Articles

Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., … & Levine, B. (2013). Autosis is a Na+, K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia. Proceedings of the National Academy of Sciences, 110(51), 20364-20371. doi:10.1073/pnas.1319661110

Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., … & Hetz, C. (2014). Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy, 10(7), 1256-1271. doi:10.4161/auto.28784

Pedro, J. M. B. S., Wei, Y., Sica, V., Maiuri, M. C., Zou, Z., Kroemer, G., & Levine, B. (2015). BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy, 11(3), 452-459. doi:10.1080/15548627.2015.1017191

Review Papers

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014). Metabolic control of autophagy. Cell, 159(6), 1263-1276. doi: 10.1016/j.cell.2014.11.006.

Levine, B., Liu, R., Dong, X., & Zhong, Q. (2015). Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends in Cell Biology, 25(9), 533-544. doi:10.1016/j.tcb.2015.05.004

Recommended Readings: Shai Shaham PH.D. Monday, March 26, 2012

A New C. elegans Cell Death Program: Implications for

Neurodegeneration and Cancer

Shai Shaham, Ph.D.

Laboratory of Developmental Genetics

The Rockefeller University

4:00 p.m. Monday, March 26, 2012    Refreshments  3:45  Abby Lounge

Caspary Auditorium

Recommended readings:

Blum, E.S., Abraham, M.C., Yoshimura, S., Lu, Y., and S. Shaham.  2012.  Control of nonapoptotic developmental cell death in Caeanorhabditis elegans by a polyglutamic-repeat proteinScience.  335(6071):970-973.  DOI: 10.1126/science.1215156

 McCall, K.  2010.  Generic control of necrosis – another type of programmed cell death Current Opinion in Cell Biology.  22(6):882-888.  DOI: 10.1016/

 Yuan, J. and G. Kroemer.  2010.  Alternative cell death mechanisms in development and beyond.  Genes & Development.  24(23):2592-2602.  DOI: 10.1101/gad.1984410

 Vlachos, M. and  N. Tavernarakis.  2010.  Non-apoptotic cell death in Caenorhabditis elegans.  Developmental Dynamics.  239(5, S1):1337-1351.   DOI: 10.1002/dvdy.22230

 Miguel-Aliaga, I. and T. Stefan.  2009.  Programmed cell death in the nervous system – a programmed cell fate?  Current Opinion in Neurobiology.  19(2):127-133   DOI: 10.1016/j.conb.2009.04.002

Blum, E.S., M. Driscoll, and S. Shaham.  2008.  Noncanonical cell death programs in the nematode Caenorhabditis elegans.  Cell Death and Differeentiation.  15(7):1124-1131.  DOI: 10.1038/cdd.2008.56

 Abraham, M. C., L. Yun, and S. Shaham.  2007.  A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabiditis elegans.   Development Cell.  12(1):73-86.  DOI:  10.1016/j.devcel.2006.11.012


Related Readings – Sidney Strickland Ph.D.

Proteases, the Extracellular Matrix and Cell Death: lessons from the overexcited brain

Monday, April 28, 2008 Welch Hall (2nd floor)

3:45 pm. Refreshments 4:00 p.m. Lecture

Recommended Review Article:

Kaul M, Lipton SA. (2005) Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research 276(20): 16593-16596

Related Articles:

Lee, S.R.; Lok, J.; Rosell, A. et al. (2007) Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience 150(1): 50-57

Chu K, Lee ST, Sinn DI, et al. (2007) Pharmacological induction of ischemic tolerance by glutamate transporter-1 (EAAT2) upregulation. Stroke 38(1):177-182

Penkowa M, Florit S, Giralt M, et al. (2005) Metallothionein reduces central nervous system inflammation, neuro degeneration, and cell death following kainic acid-induced epileptic seizures Journal of Neuroscience Research 79(4):522-534

Kaur J, Zhao ZG, Klein GM, et al. (2004) The neurotoxicity of tissue plasminogen activator? Journal of Cerebral Blood Flow and Metabolism 24(9): 945-963

Finlay M, Clements JM, et al. (2004) Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor Journal of Neurochemistry  89(6): 1378-1386

Swanson, R. A.; Ying, W.; Kaupinnen, T.M. (2004) Astrocyte influences on ischemic neuronal death Current Molecular Medicine 4(2):193-205