Recommended Readings: Seth Darst, Ph.D. Monday November 6th, 2017

Monday Lectures

Monday, November 6, 2017  3:45 p.m.

Carson Family Auditorium

Seth Darst, Ph.D.

Jack Fishman Professor and Head

Laboratory of Molecular Biophysics

The Rockefeller University

Promoter Melting by Bacterial RNA Polymerase – One Step at a Time

Recommended Readings:

Feklistov, Andrey; Bae, Brian; Hauver, Jesse; et al. (2017). RNA polymerase motions during promoter melting. SCIENCE. 356 (6340): 863-866

Hubin, Elizabeth A.; Fay, Allison; Xu, Catherine; et al. (2017). Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. ELIFE. 6

Chen, James; Wassarman, Karen M.; Feng, Shili; et al. (2017). 6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase. MOLECULAR CELL. 68 (2): 388-+

Bae, Brian; Feklistov, Andrey; Lass-Napiorkowska, Agnieszka; et al. (2015). Structure of a bacterial RNA polymerase holoenzyme open promoter complex. ELIFE. 4

Davis, Elizabeth; Chen, James; Leon, Katherine; et al. (2015). Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.  NUCLEIC ACIDS RESEARCH. 43 (1): 433-445

Chen, Jie; Darst, Seth A.; Thirumalai, D. (2010). Promoter melting triggered by bacterial RNA polymerase occurs in three steps. PNAS. 107 (28): 12523-12528

 

Recommended Readings: Seth Darst, Ph.D., November 2nd

Monday Lecture Series
Monday, November 2, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Seth Darst, Ph.D.
Jack Fishman Professor and Head,
Laboratory of Molecular Biophysics,
The Rockefeller University

CarD, an Essential Transcription Factor in Mycobacterium Tuberculosis, Uses a Minor Groove Wedge Mechanism to Stabilize the RNA Polymerase Open Promoter Complex

Recommended Readings

Empirical Articles

Bae, B., Chen, J., Davis, E., Leon, K., Darst, S. A., & Campbell, E. A. (2015). CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. eLife, e08505. doi:10.7554/eLife.08505

Davis, E., Chen, J., Leon, K., Darst, S. A., & Campbell, E. A. (2014). Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD. Nucleic Acids Research, gku1231. doi: 10.1093/nar/gku1231

Srivastava, D. B., Leon, K., Osmundson, J., Garner, A. L., Weiss, L. A., Westblade, L. F., … & Campbell, E. A. (2013). Structure and function of CarD, an essential mycobacterial transcription factor. Proceedings of the National Academy of Sciences, 110(31), 12619-12624. doi:10.1073/pnas.1308270110

Review Papers

Feklístov, A., Sharon, B. D., Darst, S. A., & Gross, C. A. (2014). Bacterial sigma factors: a historical, structural, and genomic perspective. Annual Review of Microbiology, 68, 357-376. doi:0.1146/annurev-micro-092412-155737