Recommended Readings: Irving Weissman, M.D.

Friday Lecture Series

The Philip Levine Memorial Lecture

Normal and Neoplastic Stem Cells

Irving Weissman, M.D., director,

Institute of Stem Cell Biology and Regenerative Medicine;

V&D Ludwig Professor of Clinical Cancer Research; and professor, departments of

developmental biology, pathology and neurosurgery and biology,

Stanford University School of Medicine

November 1, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Chao, M. P., Majeti, R., & Weissman, I. L. (2012). Programmed cell removal: A new obstacle in the road to developing cancer. Nature Reviews Cancer, 12(1), 58-67

Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012). Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Science Translational Medicine, 4(149)

Lu, R., Neff, N. F., Quake, S. R., & Weissman, I. L. (2011). Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nature Biotechnology, 29(10), 928-934

Pang, W. W., Pluvinage, J. V., Price, E. A., Sridhar, K., Arber, D. A., Greenberg, P. L., . . . Weissman, I. L. (2013). Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proceedings of the National Academy of Sciences of the United States of America, 110(8), 3011-3016

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., . . . Weissman, I. L. (2011). Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20012-20017

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., . . . Back, S. A. (2012). Human neural stem cells induce functional myelination in mice with severe dysmyelination. Science Translational Medicine, 4(155)

Weissman, I. (2012). Stem cell therapies could change medicine… if they get the chance. Cell Stem Cell, 10(6), 663-665


New Method Kills Rare, Aggressive Breast Cancer Stem Cells

ScienceDaily, August 17th, 2009.  A team of Boston-area researchers has discovered a chemcial that kills mouse breast concer stem cells.  Researchers do not know whether the chemical holds therapeutic potential in humans.  The finding is significant because it demonstrates that it is possible to identify chemicals that specifically kill cancer stem cells.  The results appear in the August 13 advance issue of Cell.

Related Readings: Zhe Li PhD

Special Seminar Series

Cancer Stem Cells and Their Cellular Origins

Monday June 23, 2008

Welch Hall Level 2 Refreshments 3:45 p.m. Lecture 4 p.m.

Recommended Review Article:

Wu, Xiong-Shi.  2008.  Origin of cancer stem cells: the role of self-renewal and differentiation.  Annals of Surgical Oncology.  15(2):407-414

Related Articles:

Gil, J.; Stembalska, A; et al.   2008.  Cancer Stem cells: the theory and perspectives in cancer therapy.  Journal of Applied Genetics.  49(2):193-199

Caers, J.; Van Valckemborgh, E.; et al.   2008.  Unraveling the biology of multiple myeloma disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment.  Bulletin du Cancer.  95(3): 301-313.

Li, Zhe; Tognon, C.E.;  et al.  2007.   ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complexCancer Cell.  12(6): 542-558

Li, Zhe; Godinho, F. J.; et al.  2005.  Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genetics  37(6): 1061-4036