Recommended Readings: Anne Brunet, Ph.D., March 11

Friday Lecture Series
Friday, March 11
3:45 p.m., Caspary Auditorium

Anne Brunet, Ph.D.
Michele and Timothy Barakett Endowed Professor,
Department of Genetics,
Stanford University School of Medicine

Epigenetic and Metabolic Regulation of Aging

Recommended Readings

Empirical Articles

Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., … & Brunet, A. (2014). H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158(3), 673-688. doi: 10.1016/j.cell.2014.06.027

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., … & Brunet, A. (2010). Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature, 466(7304), 383-387. doi: 10.1038/nature09195

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., … & Brunet, A. (2011). Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature, 479(7373), 365-371. doi: 10.1038/nature10572

Review Papers

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015). Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nature Reviews Molecular Cell Biology, 16(10), 593-610. doi:10.1038/nrm4048

Lim, J. P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

Recommended Readings: Jue Chen, Ph.D., February 27

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, February 25, 2015
3:45 p.m., Caspary Auditorium

Jue Chen, Ph.D.,
Head of Laboratory of Membrane Biology and Biophysics,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Understanding Molecular Pumps: Insights from Structural BiologyRecommended Readings

Empirical Articles

Chen, S., Oldham, M. L., Davidson, A. L., & Chen, J. (2013). Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. Nature, 499(7458), 364-368. doi:10.1038/nature12232

Jin, M. S., Oldham, M. L., Zhang, Q., & Chen, J. (2012). Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature. 490(7421), 566-569. doi:10.1038/nature11448

Oldham, M. L., Chen, S., & Chen, J. (2013). Structural basis for substrate specificity in the Escherichia coli maltose transport system. Proceedings of the National Academy of Sciences, 110(45), 18132-18137. doi:10.1073/pnas.1311407110

Review Papers

Chen, J. (2013). Molecular mechanism of the Escherichia coli maltose transporterCurrent Opinion in Structural Biology, 23(4), 492-498. doi: 10.1016/j.sbi.2013.03.011

Recommended Readings: Howard Hang, Ph.D. November 17

Monday Lecture Series
Monday, November 17, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Howard Hang, Ph.D.
Professor and Head,
Laboratory of Chemical Biology and Microbial Pathogenesis,
The Rockefeller University

A C. elegans Model for Commensal Bacteria Function Reveals a Secreted Peptidoglycan Hydrolase Activator of Host Immunity

Recommended Readings

Empirical Articles

Charron, G., Zhang, M. M., Yount, J. S., Wilson, J., Raghavan, A. S., Shamir, E., & Hang, H. C. (2009). Robust fluorescent detection of protein fatty-acylation with chemical reporters. Journal of the American Chemical Society, 131(13), 4967–4975. doi:10.1021/ja810122f

Hang, H. C., Geutjes, E.-J., Grotenbreg, G., Pollington, A. M., Bijlmakers, M. J., & Ploegh, H. L. (2007). Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. Journal of the American Chemical Society, 129(10), 2744–2745. doi:10.1021/ja0685001

Yount, J. S., Moltedo, B., Yang, Y.-Y., Charron, G., Moran, T. M., López, C. B., & Hang, H. C. (2010). Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nature Chemical Biology, 6(8), 610–614. doi:10.1038/nchembio.405

Review Paper

Grammel, M., & Hang, H. C. (2013). Chemical reporters for biological discovery. Nature Chemical Biology, 9(8), 475–484. doi:10.1038/nchembio.1296

Recommended Readings: Shai Shaham, Ph.D. November 10

Monday Lecture Series
Monday, November 10, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Shai Shaham, Ph.D.
Professor and Head,
Laboratory of Developmental Genetics,
The Rockefeller University

Glial Control of Neuronal Receptive Ending Form and Function

Recommended Readings

Empirical Papers

Bacaj, T., Tevlin, M., Lu, Y., & Shaham, S. (2008). Glia are essential for sensory organ function in C. elegans. Science, 322(5902), 744–747. doi:10.1126/science.1163074

Heiman, M. G., & Shaham, S. (2009). DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Cell, 137(2), 344–355. doi:10.1016/j.cell.2009.01.057

Procko, C., Lu, Y., & Shaham, S. (2011). Glia delimit shape changes of sensory neuron receptive endings in C. elegans. Development, 138(7), 1371–1381. doi:10.1242/dev.058305

Yoshimura, S., Murray, J. I., Lu, Y., Waterston, R. H., & Shaham, S. (2008). mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans. Development, 135(13), 2263–2275. doi:10.1242/dev.019547

Review Papers

Oikonomou, G., & Shaham, S. (2011). The glia of Caenorhabditis elegans. Glia, 59(9), 1253–1263. doi:10.1002/glia.21084

Procko, C., & Shaham, S. (2010). Assisted morphogenesis: glial control of dendrite shapes. Current Opinion in Cell Biology, 22(5), 560–565. doi:10.1016/j.ceb.2010.07.005

Recommended Readings: Gary Ruvkun, Ph.D. October 24

Friday Lecture Series
Friday, October 24, 2014
3:45 p.m., Caspary Auditorium

Gary Ruvkun, Ph.D.
Hans-Hermann Schoene Distinguished Investigator and Professor,
Department of Genetics,
Harvard Medical School

C. elegans Surveillance of Conserved Cellular Components to Detect and Defend Pathogen Attacks, Real or Imagined

Recommended Readings

Empirical Articles

Liu, Y., Samuel, B. S., Breen, P. C., & Ruvkun, G. (2014). Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature, 508(7496), 406–410. doi:10.1038/nature13204

Melo, J. A, & Ruvkun, G. (2012). Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell, 149(2), 452–466. doi:10.1016/j.cell.2012.02.050

Shore, D. E., Carr, C. E., & Ruvkun, G. (2012). Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genetics, 8(7), e1002792. doi:10.1371/journal.pgen.1002792

Review Papers

Shore, D. E., & Ruvkun, G. (2013). A cytoprotective perspective on longevity regulation. Trends in Cell Biology, 23(9), 409–420. doi:10.1016/j.tcb.2013.04.007