Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight


Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578



Recommended Readings: Jeffrey M. Friedman M.D., Ph.D.

Monday Lectures

Leptin and the Homeostratic Control of

Food Intake and Body Weight

Jeffrey M. Friedman M.D., Ph.D.

Howard Hughes Medical Institute

The Rockefeller University

4 p.m.  (refreshments at 3:45)

Monday, December 8, 2008

Welch Hall Level Two

Recommended Review:

Morrison, Christopher D. and Hans-Rudolf Berthoud.  2007.  Neurobiology of nutrition and obesity. Nutrition Reviews.  65(12):517-534.

Related Articles:

Rodenheffer, Matthew S.; Birsoy, Kivanc; and Jeffrey M. Friedman.  2008.   Identification of white adipocyte progenitor cells in vivo.   Cell. 135(2):240-249.


Birsoy, Kivanc; Chen, Zhu; and Jeffrey M. Friedman.  2008.  Transcriptional regulation of adipogenesis by KLF4.  Cell Metabolism.  7(4):339-347.  


Berthoud, Hans-Rudolf.  2007.  Interactions between the “cognitive” and “metabolic” brain in the control of food intake. Physiology & Behavior.  91(5):486-498.


Ruano, G.; J.W.  Goethe, et al.  2007.  Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients.  Molecular Psychiatry.  12(5):474-482.


Berthoud, Hans-Rudolf.  2006. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance.  Obesity.  14(Suppl 5):197-200.    Request article from Markus Library.