Recommended Readings: James Wells, Ph.D., February 5

Friday Lecture Series
Friday, February 5, 2016
3:45 p.m., Carson Family Caspary Auditorium

James M. Wells, Ph.D.
Professor of Pediatrics,
Perinatal Institute Endowed Professor,
Division of Development Biology,
Director for Basic Research,
Division of Endocrinology,
Cincinnati Children’s Hospital Medical Center

Pluripotent Stem Cell-based Models of Human Gastrointestinal Development and Disease

Recommended Reading

Empirical Articles

McCracken, K. W., Catá, E. M., Crawford, C. M., Sinagoga, K. L., Schumacher, M., Rockich, B. E., … & Wells, J. M. (2014). Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature. 516(7531):400-404. doi: 10.1038/nature13863.

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K., … & Shroyer, N. F. (2011). Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470(7332), 105-109. doi: 10.1038/nature09691

Watson, C. L., Mahe, M. M., Múnera, J., Howell, J. C., Sundaram, N., Poling, H. M., … & Grabowski, G. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nature Medicine, 20(11), 1310-1314. doi: 10.1038/nm.3737

Review Papers

Sinagoga, K. L., & Wells, J. M. (2015). Generating human intestinal tissues from pluripotent stem cells to study development and disease. The EMBO Journal, 34(9):1149-63. doi: 10.15252/embj.201490686

Wells, J. M., & Spence, J. R. (2014). How to make an intestine. Development, 141(4), 752-760. doi: 10.1242/dev.097386.

Recommended Readings: Naama Barkai, Ph.D.

Special Seminar Series: Systems Biology

Scaling in Embryonic Development

Naama Barkai, Ph.D.

Associate Professor, Department of Molecular Genetics

Weizmann Institue of Science

Wednesday, January 14, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Ambrosio, A. L., V. F. Taelman, H. X. Lee, C. A. Metzinger, C. Coffinier, and E. M. De Robertis. 2008. Crossveinless-2 is a BMP feedback inhibitor that binds Chordin/BMP to regulate xenopus embryonic patterning. Developmental Cell. 15(2):248-260.

Lewis, J. 2008. From signals to patterns: Space, time, and mathematics in developmental biology. Science. 322(5900):399-403.

Ben-Zvi, D., B. -Z Shilo, A. Fainsod, and N. Barkai. 2008. Scaling of the BMP activation gradient in Xenopus embryos. Nature. 453(7199):1205-1211.

Cooke, J. 1981. Scale of body pattern adjusts to available cell number in amphibian embryos. Nature. 290(5809):775-778.

De Robertis, E. M., and Kuroda, H. Dorsal-ventral patterning and neural induction in Xenopus embryos. Annual Review of Cell and Developmental Biology. 20:285-308.

Dosch, R., and C. Niehrs. 2000. Requirement for anti-dorsalizing morphogenetic protein in organizer patterning. Mechanisms of Development. 90(2):195-203.

Ferguson, E. L. 1996. Conservation of dorsal ventral patterning in arthropods and chordates. Current Opinion in Genetics and Development. 6(4):424-431.

Khokha, M. K., J. Yeh, T. C. Grammer, and R. M. Harland. 2005. Depletion of three BMP antagonists from Spemann’s Organizer leads to a catastrophic loss of dorsal structures. Developmental Cell. 8(3):401-411.