Recommended Readings: Michael Lenardo, M.D., October 23rd

Friday Lecture Series
Friday, October 23, 2015
3:45 p.m., Caspary Auditorium

Michael Lenardo, M.D.
Chief, Molecular Development Section,
Laboratory of Immunology,
Director, NIAID Clinical Genomics Program,
National Institute of Allergy and Infectious Diseases,
National Institutes of Health

Genomic Approaches to Solving Primary Immune Disorders

Recommended Readings

Empirical Articles

Kuehn, H. S., Ouyang, W., Lo, B., Deenick, E. K., Niemela, J. E., Avery, D. T., … & Uzel, G. (2014). Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science, 345(6204), 1623-1627. doi:10.1126/science.1255904.

Lo, B., Zhang, K., Lu, W., Zheng, L., Zhang, Q., Kanellopoulou, C., … & Jordan, M. B. (2015). Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science, 349(6246), 436-440. doi:10.1126/science.aaa1663.

Lucas, C. L., Zhang, Y., Venida, A., Wang, Y., Hughes, J., McElwee, J., … & Lenardo, M. J. (2014). Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. The Journal of Experimental Medicine, 211(13), 2537-2547. doi:10.1084/jem.20141759.

Review Papers

Grönholm, J., & Lenardo, M. J. (2015). Novel diagnostic and therapeutic approaches for autoimmune diabetes- A prime time to treat insulitis as a disease. Clinical Immunology, 156(2), 109-118. doi:10.1016/j.clim.2014.11.007.

Zhang, Y., Su, H. C., & Lenardo, M. J. (2015). Genomics is rapidly advancing precision medicine for immunological disorders. Nature Immunology, 16(10), 1001-1004. doi:10.1038/ni.3275

Recommended Readings: Wiley Prize in Biomedical Sciences

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Deborah E. Wiley, chair, The Wiley Foundation, Welcome

Gunter Blobel, Ph.D., chair, Wiley Prize Jury, Award Presentation and Introduction of Award Lecture

William G. Kaelin, Jr., M.D., professor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School; investigator, Howard Hughes Medical Institute, Lessons from von Hippel-Lindau Disease

Steven McKnight, Ph.D., professor and chairman, department of biochemistry, University of Texas Southwestern Medical Center, Hitting the Bullseye of HIF2a, the Kidney Cancer Oncoprotein

Peter J. Ratcliffe, M.D., professor and head, Nuffield Department of Medicine, University of Oxford, From Epo to Oxygen: Elucidation of Hypoxia Sensing in Animals

Gregg L. Semenza, M.D., Ph.D., professor and director, vascular program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Regulation of Oxygen Homeostasis by Hypoxia-inducible Factors

April 11, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beckmann, R., Spahn, C. M. T., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., . . . Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell, 107(3), 361-372

Kaelin Jr., W. G., & McKnight, S. L. (2013). Influence of metabolism on epigenetics and disease. Cell, 153(1), 56-69

McKnight, S. L. (2010). On getting there from here. Science, 330(6009), 1338-1339

Ratcliffe, P. J. (2013). Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer. Journal of Physiology, 591(8), 2027-2042

Semenza, G. L. (2013). Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene, 32(35), 4057-4063