Recommended Readings: Lora Hooper, Ph.D. April 2

Wednesday, April 2, 2014
4:00 p.m., Carson Family Auditorium

Lora Hooper, Ph.D.
University of Texas Southwestern Medical Center
Investigator, HHMI

Circadian Regulation of Intestinal Immunity

Recommended Readings:

Empirical Articles

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V, Koh, G. Y., Nagy, A., … Gordon, J. I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences, 101(44), 15718–15723. doi:10.1073/pnas.0407076101

Cash, H. L., Whitham, C. V, Behrendt, C. L., & Hooper, L. V. (2006). Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science, 313(5790), 1126–1130. doi:10.1126/science.1127119

Scheer, F. a J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proceedings of the National Academy of Sciences, 106(11), 4453–4458. doi:10.1073/pnas.0808180106

Yu, X., Rollins, D., Ruhn, K. a, Stubblefield, J. J., Green, C. B., Kashiwada, M., … Hooper, L. V. (2013). TH17 cell differentiation is regulated by the circadian clock. Science, 342(6159), 727–730. doi:10.1126/science.1243884

Review Papers

Arjona, A., Silver, A. C., Walker, W. E., & Fikrig, E. (2012). Immunity’s fourth dimension: approaching the circadian-immune connection. Trends in Immunology, 33(12), 607–612. doi:10.1016/

Hooper, L. V, & Macpherson, A. J. (2010). Immune adaptations that maintain homeostasis with the intestinal microbiota. Nature Reviews Immunology, 10(3), 159–169. doi:10.1038/nri2710

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009). IL-17 and Th17 cells. Annual Review of Immunology, 27, 485–517. doi:10.1146/annurev.immunol.021908.132710

Recommended Readings: Ueli Schibler Ph.D. February 14

Friday Lecture Series
Friday, February 14, 2014
3:45 p.m., Caspary Auditorium

Ueli Schibler, PhD
University of Geneva
Department of Molecular Biology

The Mammalian Circadian Timing System: Communication Between Clocks

Recommended Readings:

Empirical Articles

Balsalobre, A., Brown, S.A., Marcacci, L., … Schibler, U. (2000). Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science, 289(5488), 2344–2347. doi:10.1126/science.289.5488.2344

Balsalobre, A., Damiola, F., & Schibler, U. (1998). A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell, 93(6), 929–937. doi:10.1016/S0092-8674(00)81199-X

Damiola, F., Le Minh, N., Preitner, N., … Schibler, U. (2000). Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development, 14(23), 2950–2961. doi:10.1101/gad.183500

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013). Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell, 152(3), 492–503. doi:10.1016/j.cell.2012.12.027

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007). System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biology, 5(2), e34. doi:10.1371/journal.pbio.0050034

Review Papers

Dibner, C., Schibler, U., & Albrecht, U. (2010). The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annual Review of Physiology, 72, 517–549. doi:10.1146/annurev-physiol-021909-135821

Gachon, F., Nagoshi, E., Brown, S. a, Ripperger, J., & Schibler, U. (2004). The mammalian circadian timing system: from gene expression to physiology. Chromosoma, 113(3), 103–112. doi:10.1007/s00412-004-0296-2

Schibler, U., & Sassone-Corsi, P. (2002). A web of circadian pacemakers. Cell, 111(7), 919–922. doi:10.1016/S0092-8674(02)01225-4