Recommended Readings: Susan Gottesman, Ph.D.

Friday Lecture Series

The Joshua Lederberg Memorial Lecture

Bacterial sRNA Regulatory Circuits and their On and Off Switches

Susan Gottesman, Ph.D., NIH Distinguished Investigator;

co-chief, Laboratory of Molecular Biology, National Cancer Institute

January 10, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

De Lay, N., Schu, D. J., & Gottesman, S. (2013). Bacterial small RNA-based negative regulation: Hfq and its accomplices. Journal of Biological Chemistry, 288(12), 7996-8003

Gottesman, S. (2011). Microbiology: Dicing defence in bacteria. Nature, 471(7340), 588-589

Gottesman, S., & Storz, G. (2011). Bacterial small RNA regulators: Versatile roles and rapidly evolving variations. Cold Spring Harbor Perspectives in Biology, 3(12)

Mandin, P., & Gottesman, S. (2009). Regulating the regulator: An RNA decoy acts as an OFF switch for the regulation of an sRNA. Genes and Development, 23(17), 1981-1985

Soper, T., Mandin, P., Majdalani, N., Gottesman, S., & Woodson, S. A. (2010). Positive regulation by small RNAs and the role of hfq. Proceedings of the National Academy of Sciences of the United States of America, 107(21), 9602-9607


Recommended Readings: Bonnie Bassler, Ph.D.

Friday Lecture Series

Manipulating Quorum Sensing to Control Bacterial Pathogenesis

Bonnie Bassler, Ph.D., Squibb Professor in Molecular Biology and director,

Council on Science and Technology,

Princeton University

October 11, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Bassler, B., & Vogel, J. (2013). Bacterial regulatory mechanisms: The gene and beyond. Current Opinion in Microbiology, 16(2), 109-111

Chen, G., Swem, L., Swem, D., Stauff, D., O’Loughlin, C., Jeffrey, P., . . . Hughson, F. (2011). A strategy for antagonizing quorum sensing. Molecular Cell, 42(2), 199-209

Stauff, D. L., & Bassler, B. L. (2011). Quorum sensing in chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor. Journal of Bacteriology, 193(15), 3871-3878

Swem, L. R., Swem, D. L., O’Loughlin, C. T., Gatmaitan, R., Zhao, B., Ulrich, S. M., & Bassler, B. L. (2009). A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Molecular Cell, 35(2), 143-153

Teng, S. -., Schaffer, J. N., Tu, K. C., Mehta, P., Lu, W., Ong, N. P., . . . Wingreen, N. S. (2011). Active regulation of receptor ratios controls integration of quorum-sensing signals in vibrio harveyi. Molecular Systems Biology, 7