Recommended Readings: Ruth Lehmann, Ph.D., April 1

Friday Lecture Series
Friday, April 1
3:45 p.m., Caspary Auditorium

Ruth Lehmann, Ph.D.
Laura and Isaac Perlmutter Professor of Cell Biology,
Director, Skirball Institute,
Chair, Department of Cell Biology,
New York University School of Medicine
Howard Hughes Medical Institute

Mechanisms and Function of Mitochondrial Inheritance in Germ Line Stem Cells

Recommended Readings

Slaidina, M., & Lehmann, R. (2014). Translational control in germline stem cell development. The Journal of Cell Biology, 207(1), 13-21. doi: 10.1083/jcb.201407102.

Teixeira, F. K., Sanchez, C. G., Hurd, T. R., Seifert, J. R., Czech, B., Preall, J. B., … & Lehmann, R. (2015). ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nature Cell Biology, 17(5), 689-696. doi: 10.1038/ncb3165.

Recommended Readings: David M. Smith, Ph.D.

Monday Lecture Series

The Proteasomal ATPases: Regulating a Protein Degradation Machine

David M. Smith, Ph.D.

Instructor, Department of Cell Biology

Harvard Medical School

Monday, February 9, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Smith, D. M., N. Benaroudj, and A. Goldberg. 2006. Proteasomes and their associated ATPases: A destructive combination. Journal of Structural Biology. 156(1):72-83.

Dou, Q. P., D. M. Smith, K. G. Daniel, and A. Kazi. 2003. Interruption of tumor cell cycle progression through proteasome inhibition: Implications for cancer therapy. Progress in cell cycle research. 5:441-446.
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Horwitz, A. A., A. Navon, M. Groll, D. M. Smith, C. Reis, and A. L. Goldberg. 2007. ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in archaea. Journal of Biological Chemistry. 282(31):22921-22929.

Nam, S., D. M. Smith, and Q. P. Dou. 2001. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. Journal of Biological Chemistry. 276(16):13322-13330.

Rabl, J., D. M. Smith, Y. Yu, S. -C Chang, A. L. Goldberg, and Y. Cheng. 2008. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Molecular Cell. 30(3):360-368.

Smith, D. M., S. -C Chang, S. Park, D. Finley, Y. Cheng, and A. L. Goldberg. 2007. Docking of the proteasomal ATPases’ carboxyl termini in the 20S proteasome’s α ring opens the gate for substrate entry. Molecular Cell. 27(5):731-744.

 Smith, D. M., K. G. Daniel, Z. Wang, W. C. Guida, T. -H Chan, and Q. P. Dou. 2004. Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design. Proteins: Structure, Function and Genetics. 54(1):58-70.

Smith, D. M., G. Kafri, Y. Cheng, D. Ng, T. Walz, and A. L. Goldberg. 2005. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Molecular Cell. 20(5):687-698.