Recommended Readings: Timothy Ryan, Ph.D., Monday October 23th, 2017

Monday Lectures

Monday, October 23, 2017  3:45 p.m.

Carson Family Auditorium

Timothy Ryan, Ph.D.

Tri-Institutional Professor

Department of biochemistry

Weill Cornell Medical College

The Cost of Thinking: Metabolic Fitness at the Synapse Level

Recommended Readings:

Jaime de Juan Sanz (2017). The surprising metabolism of “exercising” neurons. Plos Blogs

Ashrafi, Ghazaleh; Ryan, Timothy A. (2017). Glucose metabolism in nerve terminals. CURRENT OPINION IN NEUROBIOLOGY. 45:156-161

Ashrafi, Ghazaleh; Wu, Zhuhao; Farrell, Ryan J.; et al. (2017). GLUT4 Mobilization Supports Energetic Demands of Active Synapses. NEURON. 93 (3): 606-+

Jang, SoRi; Nelson, Jessica C.; Bend, Eric G.; et al. (2016). Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function. NEURON. 90 (2): 278-291

Magistretti, Pierre J.; Allaman, Igor (2015). A Cellular Perspective on Brain Energy Metabolism and Functional Imaging. NEURON. 86 (4): 883-901

Rangaraju, Vidhya; Calloway, Nathaniel; Ryan, Timothy A.(2014). Activity-Driven Local ATP Synthesis Is Required for Synaptic Function. CELL. 156 (4): 825-835

Recommended Readings: Gulcin Pekkurnaz, Ph.D., September 21

Special Lecture
Monday, September 21, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gulcin Pekkurnaz, Ph.D.,
Postdoctoral Fellow,
Department of Neurobiology,
Harvard Medical School
Boston Children’s Hospital

Metabolic Regulation of Mitochondrial Function in the Nervous System

Recommended Readings

Empirical Articles

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D., & Schwarz, T. L. (2014). Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell, 158(1), 54-68. doi: 10.1016/j.cell.2014.06.007

Teodoro, R. O., Pekkurnaz, G., Nasser, A., Higashi‐Kovtun, M. E., Balakireva, M., McLachlan, I. G., … & Schwarz, T. L. (2013). Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst. The EMBO Journal, 32(14), 2039-2055. doi: 10.1038/emboj.2013.147

Review Papers

Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology, 5(6), a011304. doi: 10.1101/cshperspect.a011304

Recommended Readings: Timothy Ryan, Ph.D. December 8

Monday Lecture Series
Monday, December 8, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Timothy Ryan, Ph.D.
Tri-Institutional Professor,
Department of Biochemistry,
Weill Cornell Medical College

How Synapses Regulate Their Diet: the Balance of Fuel Production and Expenditure and Single Synapses

Recommended Readings

Empirical Articles

Cottrell, J. R., Levenson, J. M., Kim, S. H., Gibson, H. E., Richardson, K. a, Sivula, M., … Gerber, D. J. (2013). Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. The Journal of Neuroscience, 33(27), 10938–10949. doi:10.1523/JNEUROSCI.5362-12.2013

Fernandez-Alfonso, T., & Ryan, T. A. (2008). A heterogeneous “resting” pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses. Brain Cell Biology, 36(1-4), 87–100. doi:10.1007/s11068-008-9030-y

Kim, S. H., & Ryan, T. A. (2010). CDK5 serves as a major control point in neurotransmitter release. Neuron, 67(5), 797–809. doi:10.1016/j.neuron.2010.08.003

Rangaraju, V., Calloway, N., & Ryan, T. A. (2014). Activity-driven local ATP synthesis is required for synaptic function. Cell, 156(4), 825–835. doi:10.1016/j.cell.2013.12.042

Review Paper

Dittman, J., & Ryan, T. a. (2009). Molecular circuitry of endocytosis at nerve terminals. Annual Review of Cell and Developmental Biology, 25, 133–160. doi:10.1146/annurev.cellbio.042308.113302