Recommended Readings; Gregory J. Hannon, Ph.D., Friday, May 29th

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

“Conserved Roles of Small RNAs in Genome Defense”

Gregory J. Hannon, Ph.D., professor and chair, program in genetics and bioinformatics, Cold Spring Harbor Laboratory; investigator, Howard Hughes Medical Institute

May 29, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Malone, C. D., J. Brennecke, M. Dus, A. Stark, W. R. McCombie, R. Sachidanandam, and G. J. Hannon. 2009. Specialized piRNA pathways act in germline and somatic tissues of the drosophila ovary. Cell. 137:522–535.


Czech, B., C. D. Malone, R. Zhou, A. Stark, C. Schlingeheyde, M. Dus, N. Perrimon, et al. 2008. An endogenous small interfering RNA pathway in Drosophila. Nature. 453(7196):798-802.


Tam, O. H., A. A. Aravin, P. Stein, A. Girard, E. P. Murchison, S. Cheloufi, E. Hodges, et al. 2008. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature. 453(7194):534-538.


Zhou, R., I. Hotta, A. M. Denli, P. Hong, N. Perrimon, and G. J. Hannon. 2008. Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Molecular Cell. 32(4):592-599.


Aravin, A. A., G. J. Hannon, and J. Brennecke. 2007. The piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science. 318(5851): 761-764.


Brennecke, J., C. D. Malone, A. A. Aravin, R. Sachidanandam, A. Stark, and G. J. Hannon. 2008. An epigenetic role for maternally inherited piRNAs in transposon silencing. Science. 322(5906): 1387-1392.


Girard, A., and G. J. Hannon. 2008. Conserved themes in small-RNA-mediated transposon control. Trends in Cell Biology. 18(3)136-148.




Kim, V. N., J. Han, and M. C. Siomi. 2009. Biogenesis of small RNAs in animals. Nature Reviews Molecular Cell Biology. 10(2):126-139.

Siomi, H., and M. C. Siomi. 2009. On the road to reading the RNA-interference code. Nature. 457(7228):396-404.

Malone, C. D., and G. J. Hannon. 2009. Small RNAs as guardians of the genome. Cell. 136(4):656-668.

Recommended Readings: Thomas Tuschl Ph.D.

Monday Lectures

Small RNA Sequencing Resolves Posttranscriptional

Regulatory Networks

Thomas Tuschl  Ph.D.

Howard Hughes Medical Institute

The Rockefeller University

4 p.m.  (refreshments at 3:45)

Monday, December 15, 2008

Welch Hall Level Two

Related Articles:

Zhao, Yi; Shunmin  He,; et al.    2008.  MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control    Trends in Genetics 24(7): 323-327.


Orom, Ulf Andersson; Finn Cilius Nielsen.    2008.  MicroRNA-10a binds the 5 ‘ UTR of ribosomal protein mRNAs and enhances their translation.   Molecular Cell  30 (4):460-471.


Hudder, Alice; and Raymond F. Novak. 2008.   miRNAs: Effectors of environmental influences on gene expression and disease.   Toxicological Sciences 103(2): 228-240.


Hu Shi-Jun; Yang Zeng-Ming.  2008. Mechanisms on the regulation of miRNAs expression.  Progress in Biochemistry and Biophysics  35(5): 483-487.    Request article from Markus Library


Lee, Ji Young; Soonhag Kim; et al.   2008.    Development of a dual-luciferase reporter system for in vivo visualization of microRNA biogenesis and posttranscriptional regulation.   Journal of Nuclear Medicine 49(2):285-294.  Request article from Markus Library.


Ku, Gregory; and Michael T. McManus.  2008.    Behind the scenes of a small RNA gene-silencing pathway.  Human Gene Therapy  19(1):17-26.   Request article from Markus Library.


Diederichs, Sven; and Daniel A.Haber.  2007.   Dual role for argonautes in MicroRNA processing and Posttranscriptional regulation of MicroRNA expression.  Cell  131(6): 1097-1108.


Zeng Yan; Heidi H. Sankala  et al. 2008.   Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.  Biochemical Journal   413(part 3): 429-436.  


Ronemus, Michael; Matthew W. Vaughn;  et al.   2006.   MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by Argonaute, Dicer, and RNA-dependent RNA polymerase in Arabidopsis.   Plant Cell  18(7): 1559-1574.


 Chen, Po Yu; and Gunter Meister.    2005.   microRNA-guided posttranscriptional gene regulation.  Biological Chemistry  386(12):1205-1218.   Request article from Markus Library.