Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Friday Lectures

Friday, September 7, 2018  3:45 p.m.

Caspary Auditorium

John Hardy Ph.D.

Head of the Department of Molecular Neuroscience

Chair of the Molecular Biology of Neurological Disease

University College London

Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders

Recommended Readings:

Science News

Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today

Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM

Empirical Articles

Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7)860-875 

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9)1373-+ 

Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071

Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9)989-+

Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358

Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)

Hardy, JDuff, KHardy, KGPerez-Tur, JHutton, M(1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358

Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5

Review Paper

Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044

Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6)595-608

Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7)560-574

Book Chapter

Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 3779-100

Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31

Brain Protein netrin-1 New Clue to Alzheimers

A study from the Buck Institute for Age Research offers a revolutionary new model for Alzheimer’s disease. They have discovered a naturally occurring protein that provides a new therapeutic target, and suggests that Alzheimers is  a disorder involving an imbalance in signaling between neurons.  Read the complete report of research in Cell Death and Differentiation.

Related Readings: Tadashi Nakaya

Seminar 

A novel intracellular signaling pathway mediated FE65 and APP

 

Tadashi Nakaya, Ph.D.

Head of Laboratory, Hokkaido University

Graduate School of Pharmaceutical Sciences

 

10:00 am – 11:00 am, Monday, September 15, 2008

15th Floor Conference room, WRB

 

Recommended Review Article:

McLoughlin, D.M.; & Miller, C.C.J.  2008.  The FE65 proteins and Alzheimer’s disease.  Journal of Neuroscience Research.  86(4):744-754.  (please order copies from the Markus Library)

Related Articles:

Nakaya, T.; Kawai, T.; & Suzuki, T.  2008.  Regulation of FE65 Nuclear Translocation and Function by Amyloid β-Protein Precursor in Osmotically Stressed CellsThe Journal of Biological Chemistry.  283(27):19119-19131.

Müller, T.; et al.  2008.  The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer’s diseaseProgress in Neurology.  85(4):393-406.

Nakaya, T.; & Suzuki, T.  2006.  Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICDGenes to Cells.  11(6):633-645.