Recommended Readings: Shai Shaham, Ph.D., Monday April 16, 2018

Monday Lectures

Monday, April 16, 2018  4:00 p.m.

Carson Family Auditorium

Shai Shaham, Ph.D.

Richard E. Salomon Family Professor and Head

Laboratory of Developmental Genetics

The Rockefeller University

Uncovering Cell Death Treasure Hiding in Plain Sight

Recommended Readings:

Science News

Brandon Specktor. See How a Single Cell Dies in Gory, Intricate Detail. (March 28, 2018). Live Science

Empirical Articles

Ghose P, Rashid A, Insley P, Trivedi M, Shah P, Singhal A, Lu Y, Bao Z, Shaham S. (2018). EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans. NATURE CELL BIOLOGY. 20 (4):393-399

Malin, Jennifer A.; Kinet, Maxime J.; Abraham, Mary C.; et al. (2016). Transcriptional control of non-apoptotic developmental cell death in C-elegans. CELL DEATH AND DIFFERENTIATION. 23 (12): 1985-1994

Schwendeman, Andrew R.; Shaham, Shai. (2016). A High-Throughput Small Molecule Screen for C-elegans Linker Cell Death Inhibitors. PLOS ONE. 11 (10) 

Kinet, Maxime J.; Malin, Jennifer A.; Abraham, Mary C.; et al. (2016). HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. ELIFE. 5

Blum, Elyse S.; Abraham, Mary C.; Yoshimura, Satoshi; et al. (2012). Control of Nonapoptotic Developmental Cell Death in Caenorhabditis elegans by a Polyglutamine-Repeat Protein. SCIENCE. 335 (6071): 970-973

Review Papers

Kutscher, Lena M.; Shaham, Shai (2017). Non-apoptotic cell death in animal development. CELL DEATH AND DIFFERENTIATION. 24 (8): 1326-1336

Blum, Elyse S.; Schwendeman, Andrew R.; Shaham, Shai. (2013). PolyQ disease: misfiring of a developmental cell death program? TRENDS IN CELL BIOLOGY. 23 (4): 168-174  

Book Chapters

Malin, Jennifer Zuckerman; Shaham, Shai. (2015). Cell Death in C. elegans Development. CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 114: 1-42

Kinet, Maxime J.; Shaham, Shai. (2014). Noncanonical Cell Death in the Nematode Caenorhabditis elegans. METHODS IN ENZYMOLOGY. 545: 157-180


Recommended Readings: Shai Shaham PH.D. Monday, March 26, 2012

A New C. elegans Cell Death Program: Implications for

Neurodegeneration and Cancer

Shai Shaham, Ph.D.

Laboratory of Developmental Genetics

The Rockefeller University

4:00 p.m. Monday, March 26, 2012    Refreshments  3:45  Abby Lounge

Caspary Auditorium

Recommended readings:

Blum, E.S., Abraham, M.C., Yoshimura, S., Lu, Y., and S. Shaham.  2012.  Control of nonapoptotic developmental cell death in Caeanorhabditis elegans by a polyglutamic-repeat proteinScience.  335(6071):970-973.  DOI: 10.1126/science.1215156

 McCall, K.  2010.  Generic control of necrosis – another type of programmed cell death Current Opinion in Cell Biology.  22(6):882-888.  DOI: 10.1016/

 Yuan, J. and G. Kroemer.  2010.  Alternative cell death mechanisms in development and beyond.  Genes & Development.  24(23):2592-2602.  DOI: 10.1101/gad.1984410

 Vlachos, M. and  N. Tavernarakis.  2010.  Non-apoptotic cell death in Caenorhabditis elegans.  Developmental Dynamics.  239(5, S1):1337-1351.   DOI: 10.1002/dvdy.22230

 Miguel-Aliaga, I. and T. Stefan.  2009.  Programmed cell death in the nervous system – a programmed cell fate?  Current Opinion in Neurobiology.  19(2):127-133   DOI: 10.1016/j.conb.2009.04.002

Blum, E.S., M. Driscoll, and S. Shaham.  2008.  Noncanonical cell death programs in the nematode Caenorhabditis elegans.  Cell Death and Differeentiation.  15(7):1124-1131.  DOI: 10.1038/cdd.2008.56

 Abraham, M. C., L. Yun, and S. Shaham.  2007.  A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabiditis elegans.   Development Cell.  12(1):73-86.  DOI:  10.1016/j.devcel.2006.11.012


Recommended Readings: Hermann Steller Ph.D. June 7 2010

Monday Seminar Series

Regulation of Apoptosis by the Ubiquitin-Proteasome System

Hermann Steller, Ph.D.,


Strang Professor; Investigator, HHMI
Strang Laboratory of Apoptosis and Cancer Biology

 June 7, 2010

3:45 p.m.-5:00 p.m.  Welch Hall Level Two

Recommended Readings:

Cecarini V, Quassinti L, Di Blasio A, et al.  2010. Effects of thymoquinone on isolated and cellular proteasomes .   FEBS JOURNAL   277( 9): 2128-2141

Bader M, Steller H.  2009. Regulation of cell death by the ubiquitin-proteasome system .  CURRENT OPINION IN CELL BIOLOGY.   21 (6): 878-884   

Sombroek D, Hofmann TG. 2009.  How cells switch HIPK2 on and off.   CELL DEATH AND DIFFERENTIATION  16 ( 2): 187-194

Haimerl F, Erhardt A, Sass G, et al.  2009.  Down-regulation of the De-ubiquitinating Enzyme Ubiquitin-specific Protease 2 Contributes to Tumor Necrosis Factor-alpha-induced Hepatocyte Survival.  JOURNAL OF BIOLOGICAL CHEMISTRY.   284( 1): 495-504

Uvarov AV, Mesaeli N .  2008. Enhanced ubiquitin-proteasome activity in calreticulin deficient cells: A compensatory mechanism for cell survival.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH    1783( 6): 1237-1247  

Steller H.  2008. Regulation of apoptosis in DrosophilaCELL DEATH AND DIFFERENTIATION.  15(7): 1132-1138   

Ohsawa, S., Hamada, S., Yoshida, H., and Miura, M.  2008.  Caspase-mediate changes in hostone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neuronsCell Death and Differentiation.  15:1429-1439.

Schile AJ, Garcia-Fernandez M, Steller H  2008.  Regulation of apoptosis by XIAP ubiquitin-ligase activity.  GENES & DEVELOPMENT    22(16): 2256-2266 

Tsuruta T, Oh-hashi K, Kiuchi K, et al.  2008.  Degradation of caspase-activated DNase by the ubiquitin-proteasome system.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS.   1780( 5): 793-799   

Naujokat C, Fuchs D, Berges C. 2007. Adaptive modification and flexibility of the proteasome system in response to proteasome inhibition BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.: 1773 ( 9): 1389-1397  

Mazroui R, Di Marco S, Kaufman RJ, et al. 2007.  Inhibition of the ubiquitin-proteasome system induces stress granule formation.   MOLECULAR BIOLOGY OF THE CELL.  18( 7): 2603-2618

Ryoo HD, Gorenc T and Stellar H.   2004.  Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.   Developmental Cell  7(4): 491-501

Arama E, Agapite J, Steller H.  2003.  Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila .   DEVELOPMENTAL CELL.   4( 5): 687-697











Recommended Readings: Dennis W. Wolan, Ph.D. Jan 25, 2010

Monday Lecture Series

Directed Small Molecule Activation of Apoptotic Procaspases

Dennis W. Wolan, Ph.D.,

Post Doctoral Fellow, Department of Pharmaceutical Chemistry

University of California, San Francisco

January 25, 2010

Welch Hall,  Level Two

4:00p.m.-5:00 p.m

Recommended Articles:

Wolan DW, Zorn JA, Gray DC, et al.  2009.  Small-Molecule Activators of a Proenzyme SCIENCE 326( 5954): 853-858

Eisenstein M.  2010.  Caught in action. NATURE METHODS 7(1): 12-12

Chereau D, Zou H, Spada AP, et al.  2005.  A nucleotide binding site in caspase-9 regulates apoptosome activation.    BIOCHEMISTRY 44(13): 4971-4976

Wu JM, Gorman A, Zhou XH, et al.  2002.  Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 43(10): 3349-3354

Henzing AJ, Dodson H, Reid JM, et al.   2006.  Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo .    JOURNAL OF MEDICINAL CHEMISTRY 49(26):7636-7645

Denault JB;  Drag M.;  Salvesen GS;  Alves J;  Heidt AB; Deveraux Q ; Harris JL .  2007.  Small molecules not direct activators of caspases. NATURE CHEMICAL BIOLOGY 3(9): 519-519

BOATRIGHT KM; Salveson GS.  2003.  Mechanisms of caspase activation. CURRENT OPINION IN CELL BIOLOGY 15: 725

BLANC C.  2000.  Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. CANCER RESEARCH 60 : 4386-4390

Recommended Readings: Jerry Chipuk Ph.D. Oct 5, 2009

Monday Lecture Series

Mitochondrial Outer Membrane Permeabilization and Apoptosis are Regulated by Collaborative Interactions between the BCL-2 Family and Mitochondrial Physiology

Jerry Chipuk, Ph.D.

Postdoctoral Fellow, Deptartment of Immunology, St. Jude Children’s Research Hospital

Monday, October 5, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Review Article:

Chipuk JE, Green DR.  2008.  How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?  TRENDS IN CELL BIOLOGY 18(4): 157-164

Recommended Articles:

Aslan JE, Thomas G.  2009.  Death by Committee: Organellar Trafficking and Communication in Apoptosis.  TRAFFIC 10(10): 1390-1404

Chipuk JE, Green DR.  2009.  PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis.  CELL CYCLE 8(17): 2692-2696

Chipuk JE, Bouchier-Hayes L, Green DR.  2006.  Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.  CELL DEATH AND DIFFERENTIATION 13(8): 1396-1402

Chipuk JE, Green DR.  2006.   Dissecting p53-dependent apoptosis.  CELL DEATH AND DIFFERENTIATION 13(6): 994-1002

Chipuk JE, Bouchier-Hayes L, Kuwana T, et al.  2005. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 .  SCIENCE 309(5741): 1732-1735

Kuwana T, Bouchier-Hayes L, Chipuk JE, et al.  2005.  BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly.  MOLECULAR CELL 17 (4): 525-535

Chipuk JE, Kuwana T, Bouchier-Hayes L, et al.  2004.   Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.  SCIENCE 303(5660): 1010-1014

Related Readings – Sidney Strickland Ph.D.

Proteases, the Extracellular Matrix and Cell Death: lessons from the overexcited brain

Monday, April 28, 2008 Welch Hall (2nd floor)

3:45 pm. Refreshments 4:00 p.m. Lecture

Recommended Review Article:

Kaul M, Lipton SA. (2005) Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research 276(20): 16593-16596

Related Articles:

Lee, S.R.; Lok, J.; Rosell, A. et al. (2007) Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience 150(1): 50-57

Chu K, Lee ST, Sinn DI, et al. (2007) Pharmacological induction of ischemic tolerance by glutamate transporter-1 (EAAT2) upregulation. Stroke 38(1):177-182

Penkowa M, Florit S, Giralt M, et al. (2005) Metallothionein reduces central nervous system inflammation, neuro degeneration, and cell death following kainic acid-induced epileptic seizures Journal of Neuroscience Research 79(4):522-534

Kaur J, Zhao ZG, Klein GM, et al. (2004) The neurotoxicity of tissue plasminogen activator? Journal of Cerebral Blood Flow and Metabolism 24(9): 945-963

Finlay M, Clements JM, et al. (2004) Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor Journal of Neurochemistry  89(6): 1378-1386

Swanson, R. A.; Ying, W.; Kaupinnen, T.M. (2004) Astrocyte influences on ischemic neuronal death Current Molecular Medicine 4(2):193-205