Recommended Readings: Sean F. Brady, Ph.D., Friday October 27th, 2017

Friday Lectures

Friday, October 27, 2017  3:45 p.m.

Caspary Auditorium

Sean F. Brady, Ph.D.

Evnin Associate Professor and Head

Laboratory of Genetically Encoded Small Molecules

The Rockefeller University

Watch your step, there is new chemistry everywhere

Recommended Readings:

Cohen LJ, Han S, Huang YH, Brady SF. (2017). Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library.  ACS Infect Dis.  In Press doi: 10.1021/acsinfecdis.7b00081

Fierer, Noah (2017). Embracing the unknown: disentangling the complexities of the soil microbiome. NATURE REVIEWS MICROBIOLOGY. 15 (10): 579-590

Chu, John; Vila-Farres, Xavier; Inoyama, Daigo; et al. (2016). Discovery of MRSA active antibiotics using primary sequence from the human microbiome.  NATURE CHEMICAL BIOLOGY. 12 (12): 1004-+

O’Brien, Sarah L.; Gibbons, Sean M.; Owens, Sarah M.; et al. (2016). Spatial scale drives patterns in soil bacterial diversity.  ENVIRONMENTAL MICROBIOLOGY. 18 (6): 2039-2051

Medema, Marnix H.; Kottmann, Renzo; Yilmaz, Pelin; et al. (2015). Minimum Information about a Biosynthetic Gene cluster. NATURE CHEMICAL BIOLOGY. (11) 9: 625-631

Owen, Jeremy G.; Reddy, Boojala Vijay B.; Ternei, Melinda A.; et al. (2013). Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. PNAS. 110 (29): 11797-11802  


The Much Maligned Tick: Key to a New Class of Antibiotics?

Yale researchers have discovered a glycoprotein in ticks (Ixodidae) that kicks in during winter to protect them from the cold also fights infection.  This protein may be the key to a new class of an antibiotics to help  in the battle against dangers pathogens such as MRSA.
Read more at:

Recommended Readings: Christopher T. Walsh, Ph.D.

Friday Lecture Series

Peptide-based Natural Antibiotics Strategies for Scaffold Transformation

 Christopher T. Walsh, Ph.D.

Hamilton Kuhn Professor, Department of Biological Chemsitry and Molecular Pharmacology

Harvard Medical School

Friday, February 20, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Nolan EM, Walsh CT. 2009.  How Nature Morphs Peptide Scaffolds into Antibiotics
CHEMBIOCHEM   10(1 ):34-53   


Magarvey NA, Fortin PD, Thomas PM, et al.  2008. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. ACS CHEMICAL BIOLOGY  3(9):542-554   


Roege KE, Kelly WL. 2009. Biosynthetic Origins of the Ionophore Antibiotic Indanomycin.  ORGANIC LETTERS   11(2): 297-300   


Bumpus SB, Kelleher NL.  2008.  Accessing natural product biosynthetic processes by mass spectrometry.  CURRENT OPINION IN CHEMICAL BIOLOGY . 12(5): 475-482   


Watanabe K.  2008.  Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   72(10):2491-2506   


Howard-Jones AR, Kruger RG, Lu W, et al.. 2007.   Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin.  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(33):10082-+   


La Clair JJ .  2006.  Cellular routines in the synthesis of cyclic peptide probes. TETRAHEDRON   62(22):5347-5354


Kruger RG, Lu W, Oberthur M, et al. 2005. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.  CHEMISTRY & BIOLOGY   12(1):131-140  


Gruenewald S, Mootz HD, Stehmeier P, et al.   2004.  In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY    70(6): 3282-3291

Recommended Readings: Lars Dietrich, Ph.D.

Monday Lecture Series

Redox-active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria

Lars Dietrich, Ph.D.

Postdoctoral Fellow, Department of Biology

Massachusetts Institute of Technology

Monday, March 16, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Dietrich, L. E. P., A. Price-Whelan, A. Petersen, M. Whiteley, and D. K. Newman. 2006. The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa. Molecular Microbiology. 61(5):1308-1321.

Dietrich, L. E. P., T. K. Teal, A. Price-Whelan, and D. K. Newman. 2008. Redox-active antibiotics control gene expression and community behavior in divergent bacteria. Science. 321(5893):1203-1206.

Gorodetsky, A. A., L. E. P. Dietrich, P. E. Lee, B. Demple, D. K. Newman, and J. K. Barton. 2008. DNA binding shifts the redox potential of the transcription factor SoxR. Proceedings of the National Academy of Sciences of the United States of America. 105(10):3684-3689.

Price-Whelan, A., L. E. P. Dietrich, and D. K. Newman. 2007. Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14. Journal of Bacteriology. 189(17):6372-6381.

Price-Whelan, A., L.E.P. Dietrich, and D. K. Newman. 2006. Rethinking ‘secondary’ metabolism: Physiological roles for phenazine antibiotics. Nature Chemical Biology. 2(2):71-78.