Research published August 27 in Chemistry & Biology demonstrates the viability of the NAD(P) biosynthesis pathway in bacterial pathogens as an antibiotic target for new broad spectrum antibiotics.
A Path to New Antibiotics
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Tag Archives: antibiotics
Recommended Readings: Christopher T. Walsh, Ph.D.
Friday Lecture Series
Peptide-based Natural Antibiotics Strategies for Scaffold Transformation
Christopher T. Walsh, Ph.D.
Hamilton Kuhn Professor, Department of Biological Chemsitry and Molecular Pharmacology
Harvard Medical School
Friday, February 20, 2009
3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)
Caspary Auditorium
Recommended Articles:
Nolan EM, Walsh CT. 2009. How Nature Morphs Peptide Scaffolds into Antibiotics
CHEMBIOCHEM 10(1 ):34-53
Magarvey NA, Fortin PD, Thomas PM, et al. 2008. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. ACS CHEMICAL BIOLOGY 3(9):542-554
Roege KE, Kelly WL. 2009. Biosynthetic Origins of the Ionophore Antibiotic Indanomycin. ORGANIC LETTERS 11(2): 297-300
Bumpus SB, Kelleher NL. 2008. Accessing natural product biosynthetic processes by mass spectrometry. CURRENT OPINION IN CHEMICAL BIOLOGY . 12(5): 475-482
Watanabe K. 2008. Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72(10):2491-2506
Howard-Jones AR, Kruger RG, Lu W, et al.. 2007. Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(33):10082-+
La Clair JJ . 2006. Cellular routines in the synthesis of cyclic peptide probes. TETRAHEDRON 62(22):5347-5354
Kruger RG, Lu W, Oberthur M, et al. 2005. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. CHEMISTRY & BIOLOGY 12(1):131-140
Gruenewald S, Mootz HD, Stehmeier P, et al. 2004. In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 70(6): 3282-3291
Recommended Readings: Lars Dietrich, Ph.D.
Monday Lecture Series
Redox-active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria
Lars Dietrich, Ph.D.
Postdoctoral Fellow, Department of Biology
Massachusetts Institute of Technology
Monday, March 16, 2009
4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)
Second Floor, Welch Hall
Recommended Articles:
Dietrich, L. E. P., A. Price-Whelan, A. Petersen, M. Whiteley, and D. K. Newman. 2006. The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa. Molecular Microbiology. 61(5):1308-1321.
Dietrich, L. E. P., T. K. Teal, A. Price-Whelan, and D. K. Newman. 2008. Redox-active antibiotics control gene expression and community behavior in divergent bacteria. Science. 321(5893):1203-1206.
Gorodetsky, A. A., L. E. P. Dietrich, P. E. Lee, B. Demple, D. K. Newman, and J. K. Barton. 2008. DNA binding shifts the redox potential of the transcription factor SoxR. Proceedings of the National Academy of Sciences of the United States of America. 105(10):3684-3689.
Price-Whelan, A., L. E. P. Dietrich, and D. K. Newman. 2007. Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14. Journal of Bacteriology. 189(17):6372-6381.
Price-Whelan, A., L.E.P. Dietrich, and D. K. Newman. 2006. Rethinking ‘secondary’ metabolism: Physiological roles for phenazine antibiotics. Nature Chemical Biology. 2(2):71-78.