Friday Lecture Series
Friday, October 17, 2014
3:45 p.m., Caspary Auditorium

Susan Lindquist, Ph.D.
Professor of Biology,
Massachussetts Institute of Technology
Member,
Whitehead Institute for Biomedical Research
Investigator,
Howard Hughes Medical Institute

From Yeast to Patient Neurons and Back Again: Powerful Discovery Platforms Combatting Neurodegenerative Disease

Recommended Readings

Empirical Articles

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., … Lindquist, S. (2013). Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science, 342(6161), 983–987. doi:10.1126/science.1245296

Tardiff, D. F., Jui, N. T., Khurana, V., Tambe, M. A, Thompson, M. L., Chung, C. Y., … Lindquist, S. (2013). Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science, 342(6161), 979–983. doi:10.1126/science.1245321

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., … Lindquist, S. (2011). Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast. Science, 334(6060), 1241–1245. doi:10.1126/science.1213210

Review Papers

Khurana, V., & Lindquist, S. (2010). Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast? Nature Reviews Neuroscience, 11(6), 436–449. doi:10.1038/nrn2809

Tardiff, D. F., Khurana, V., Chung, C. Y., & Lindquist, S. (2014). From yeast to patient neurons and back again: A powerful new discovery platform. Movement Disorders, 29(10), 1231–1240. doi:10.1002/mds.25989